FIGURE

Fig. 3

ID

ZDB-FIG-091116-3

Publication

Malicki et al., 1996 - Mutations affecting development of the zebrafish ear

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Fig. 3

Phenotypes resulting from mutations affecting early morphogenesis of the otic vesicle. At 30 hpf the otic vesicles of (A) mind bomb (mib)^m178; (B) snakehead (snk)^m273; (C) pandora (pan)^m313; and (D) flachland (fll)^m517 mutants are of abnormal size and shape (compare with the wild type in Fig. 1A). Formation of otoliths is also affected in these mutants. Epithelial protrusions form in the otic vesicle of mib^m178 at 60 hpf (arrowhead in E). At 60 hpf the otic vesicle of snk^m273 frequently does not form protrusions and appears to be disproportionately large compared to other organs (F). Arrowheads in A-D indicate the midbrain-hindbrain boundary. In all panels anterior is left and dorsal up.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	atp1a1a.1^m273/m273 (AB) fll^m517/m517 (AB) mib1^m178/m178 (AB) supt6h^m313/m313 (AB)
Observed In:	inner ear otic vesicle otic vesicle epithelium otolith semicircular canal
Stage Range:	Prim-15 to Pec-fin

Phenotype Detail

Acknowledgments

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