FIGURE

Fig. 9

ID

ZDB-FIG-091113-118

Publication

Sanek et al., 2009 - Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expression

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Fig. 9

Zic2a patterns the OS and retina in an Hh-dependent manner. (A-D) Zic2a-depleted WT siblings show expanded pax2a (B, 99/99 embryos, n=4), whereas smo^-/- mutants injected with conMO lose pax2a expression (C, 12/12 embryos, n=2). zic2aMO-injected smo^-/- mutants show a rescued pax2a phenotype (D, 30/30 embryos, n=4). (E-H) Co-injection of conMO and shha mRNA, or injection of zic2aMO alone, causes moderately expanded pax2a expression (F, 20/34 embryos, n=2; G, 30/30 embryos, n=2, respectively). Embryos injected with zic2aMO and shha mRNA show strong pax2a expansion (H, 23/33 embryos, n=2). Arrowheads mark the OS. Panels A-H are lateral view, anterior to the left. Panels A′-H′ are ventral views of the same embryos, anterior to the left. All embryos are at prim-5.

Expression Data

Gene:	pax2a
Fish:	AB smo^b641/b641 AB + MO3-zic2a smo^b641/b641 + MO3-zic2a
Knockdown Reagent:	MO3-zic2a
Anatomical Terms:	optic cup optic stalk
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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