FIGURE

Fig. 3

ID

ZDB-FIG-090421-4

Publication

Sakamoto et al., 2009 - Heterochronic shift in Hox-mediated activation of sonic hedgehog leads to morphological changes during fin development

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Fig. 3

hox transcript accumulation is critical for the onset of shh expression in fin development.

(A) Expression of shh in pectoral fin primordia of D. rerio embryos injected with 5 ng control MO, 20 pg hoxd10a mRNA, 20 pg hoxd13a mRNA or 20 pg hoxa13a mRNA at 22.5 hpf. Red ovals highlight the pectoral fin primordia. Note that transcripts of shh became detectable at 22.5 hpf in the fin primordia of embryos injected with hoxd10a, hoxd13a or hoxa13a mRNA. (B) The percentage of embryos with the indicated level of shh expression at 22.5 hpf following injection of control MO, hoxd10a mRNA, hoxd13a mRNA or hoxa13a mRNA is shown in the bottom panel (see also Figure S4). A representative image depicting the detectable or undetectable levels of shh expression in the pectoral fin primordia is shown at the left.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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