FIGURE

Fig. 3

ID

ZDB-FIG-090401-35

Publication

Sassi-Messai et al., 2009 - The phytoestrogen genistein affects zebrafish development through two different pathways

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Fig. 3

Genistein-induced apoptosis is estrogen receptor independent.

(A,B) estradiol does not induce apoptosis. Embryos treated with 1 μM of E2 from 5 hpf onwards display the same pattern of apoptosis (retina and epiphysis) as controls (compare A and B). In contrast embryos treated with 1 μM ICI 182,780 exhibit an increased number of apoptotic cells in the hindbrain (C). Genistein induce an apoptosis at 5 mM as shown Figure 1 (D) and cotreatments with E2 (E) or ICI 182,780 (F) does not modify this effet. Effects of treatments with half dose (0.5 μM for E2 and ICI 182,780 and 2.5 μM for genistein) led to the same conclusions. See Supplementary Figure 2 for the quantitative analysis of these results.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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