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ZIRC
ZFIN ID: ZDB-FIG-090226-1
Baker et al., 2008 - Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart. Proc. Natl. Acad. Sci. USA   105(37):13924-13929 Full text @ Proc. Natl. Acad. Sci. USA
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Knockdown Reagent:
Anatomical Term:
Stage Range: 14-19 somites to 20-25 somites
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage Range: 14-19 somites to 20-25 somites

Fig. 2

Asymmetric atrial cell migration promotes rotation of the cardiac cone. (A–H) Dorsal views of the heart in Tg(cmlc2:egfp) embryos between 18–21 hpf. (A–D) Dotted white lines indicate the embryonic midline. (E–H) Arrows indicate trajectories of left (red) and right (yellow) cells. A, E, C, and G are the first frames of time lapses (0 min), and B, F, D, and H are the final frames (180 min). A, B, E, and F are frames from a time lapse of a single WT embryo, and C, D, G, and H are frames from a time lapse of a single swt morphant. In WT embryos, the left atrial myocardium migrates asymmetrically along the left of the cone toward the left and anterior (E and F). The right cardiac cells also migrate toward the anterior and left, but rather than sweeping along the lateral edge of the cone, these cells migrate toward the lumen (E and F). In swt morphants the L/R directionality of these cellular trajectories is reversed (C, D, G, and H). L, left; R, right.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP twu34Tg standard conditions 14-19 somites to 20-25 somites heart rudiment IFL
twu34Tg + MO1-dnaaf1 standard conditions 14-19 somites to 20-25 somites heart rudiment IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
twu34Tg + MO1-dnaaf1 standard conditions 14-19 somites - 20-25 somites heart morphogenesis disrupted, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Proc. Natl. Acad. Sci. USA for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Proc. Natl. Acad. Sci. USA