FIGURE

Fig. 7

ID

ZDB-FIG-090224-52

Publication

Dowling et al., 2009 - Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathy

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Fig. 7

MTMR rescue of the myotubularin morphant phenotype.

(A) Whole mount in situ hybridization of 24 hpf embryos reveals muscle staining for myotubularin (MTM1 AS) and not for MTMR1 or MTMR2 (data not shown). A sense probe to MTM1 (MTM1 S) was used as a background control. (B) RNA rescue experiment. RNA to MTM1, MTMR1 or MTMR2 was co-injected with myotubularin morpholino. Rescue was determined by the % of hatched embryos at 60 hpf. Values were: No RNA (35.5%+/-3.3%, N = 201), MTM1 RNA (71%+/-4.5, N = 100, p (when compared to No RNA)<0.0001), MTMR1 RNA (82%+/-5.5%, N = 50, p<0.001), MTMR2 RNA (54.6%+/-5.1% N = 97, p = 00015).

Expression Data

Gene:	mtm1
Fish:	WT
Anatomical Term:	muscle
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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