Fig. 2
- ID
- ZDB-FIG-081219-31
- Publication
- Gansner et al., 2008 - Essential role for the alpha 1 chain of type VIII collagen in Zebrafish notochord formation
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Electron microscopy reveals notochord abnormalities in gulm208 mutants. A-E: Transmission electron micrographs of truncal cross-sections from embryos at 24 hpf. A: Notochord sheath and vacuolated notochord cell of a wild-type embryo, with small areas of protein accumulation visible in the rough endoplasmic reticulum (arrow). B: Notochord sheath and vacuolated notochord cell of a gulm208 mutant with large circular aggregates of protein in the rough endoplasmic reticulum (arrow). C: Notochord and hypochord of a gulm208 mutant with large circular aggregrates of protein in the hypochord (red arrows) and notochord (yellow arrow). D: Notochord sheath of a wild-type embryo with inner (i), medial (m), and outer (o) layers indicated. Small areas of protein accumulation are visible in the rough endoplasmic reticulum (red arrow). E: Notochord sheath of a gulm208 mutant where the collagen fibrils in the medial (m) layer appear disorganized. A large circular aggregate of protein is visible in the rough endoplasmic reticulum (red arrow). Not, vacuolated notochord cell; Hyp, hypochord. |
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Observed In: | |
Stage: | Prim-5 |