FIGURE

Fig. 1

ID

ZDB-FIG-081219-30

Publication

Gansner et al., 2008 - Essential role for the alpha 1 chain of type VIII collagen in Zebrafish notochord formation

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Fig. 1

gul^m208 mutants are sensitized to lysyl oxidase inhibition. A-F: Clutches from gul^m208/+ intercrosses were incubated in vehicle (A,B), the copper chelator neocuproine (2 μM; C,D), or the lysyl oxidase inhibitor β-aminopropionitrile (1 mM; E,F). The notochord is normal in wild-type embryos treated with vehicle, neocuproine, or β-aminopropionitrile (A,C,E). Notochords of gul^m208 mutants incubated in neocuproine and β-aminopropionitrile (D,F, arrowheads) are substantially more distorted than mutants incubated in vehicle (B, arrowheads). Insets show notochord at higher magnification. Embryos were treated with PTU to inhibit melanin pigmentation and photographed at 30 hours postfertilization (hpf).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	col8a1a^m208/m208
Observed In:	extension notochord notochord formation
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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