FIGURE

Fig. 9

ID

ZDB-FIG-080904-2

Publication

Owens et al., 2008 - Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death

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Fig. 9

sentinel mutation and PROTO-1 do not protect against cisplatin.
Hair cell survival was quantified using the vital dye DASPEI, and in each case DASPEI scores were normalized to those from wildtype, untreated fish. Fish (n≥12 fish per treatment group) were treated in cisplatin for 4 hours, then allowed to recover for 3 hours prior to DASPEI assessment. (A) Hair cell responses in wild-type versus sentinel mutants. No difference in the dose-response relationship was observed between wildtype fish (green), homozygous sentinel mutants (red, sinusoidal body), and sentinel siblings (blue, including heterozygous and homozygous wildtype sibling, straight body). (B) Response of cisplatin-treated hair cells from wildtype fish in the presence of the potentially protective compound PROTO-1. There is no difference between dose-response curves with (red) and without (green) PROTO-1. Error bars represent ±1 S.D.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB cc2d2a^w38/w38 (AB)
Conditions:	chemical treatment: cisplatin chemical treatment: drug
Observed In:	neuromast hair cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

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