FIGURE

Fig. 1

ID

ZDB-FIG-080529-50

Publication

Starr et al., 2004 - Mutation of the zebrafish choroideremia gene encoding Rab escort protein 1 devastates hair cells

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Fig. 1

Morphology of ru848 mutant and WT larvae at 5 dpf. (A) A transilluminated mutant larva (Lower) lacks an inflated swim bladder and has a slightly smaller eye than the WT (Upper). (B) Incident illumination shows reflective iridiphores that cover almost the entire eye in the WT larva (Upper) but are sparse in the mutant (Lower). (C) In a transmission electron micrograph, the photoreceptor outer segments (OS) in the WT retina are neatly arrayed and interdigitated with processes of the pigment-epithelial cells. (D) In the mutant retina, the outer segments are disheveled and the pigment-epithelial cells are hypertrophic and disorganized. A cluster of cytoplasmic inclusions in a mutant pigment epithelial cell is marked by a red arrowhead. CL, choroid layer; PEN, pigment epithelial nucleus. (Scale bars: 500 μm, A and B;5 μm, C and D.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	chm^ru848/ru848
Observed In:	eye eye iridophore eye pigmentation lens posterior surface photoreceptor outer segment layer pigmented epithelial cell inclusion body retinal outer nuclear layer retinal pigmented epithelium retinal pigmented epithelium pigmented epithelial cell swim bladder
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA