FIGURE

Fig. 6

ID

ZDB-FIG-080507-16

Publication

Watson et al., 2008 - The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation

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Fig. 6

CB1 is required for the axonal outgrowth and fasciculation. (A–C) Neurofilament immunofluorescence of the hindbrain of zebrafish embryos, 72 hpf. (A) Control. (B) MO1 injected embryo (C) MO2 injected embryo. (D–I) Acetylated tubulin immunofluorescence of the anterior forebrain of zebrafish embryos, at prim 12. (D–F) Frontal views. (D) Control. (E) MO1 injected embryo. (F) MO2 injected embryo. (G–I) Side views. (G) Control. (H) MO1 injected embryo (I) MO2 injected embryo. (J–L) Side views of the trunk regions of 48 hpf zebrafish embryos stained with anti-neurofilament antibody (J) Control. (K) MO1 injected embryo. (L) MO2 injected embryo. Abbreviations: AC—anterior commissure, POC—posterior commissure, SOC—Supraoptic commissure, N—neurons.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-cnr1 WT + MO2-cnr1
Knockdown Reagents:	MO1-cnr1 MO2-cnr1
Observed In:	anterior commissure morphogenesis axonal fasciculation medial longitudinal fasciculus posterior commissure morphogenesis spinal cord motor neuron
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Molecular and cellular neurosciences, 38(1), Watson, S., Chambers, D., Hobbs, C., Doherty, P., and Graham, A., The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation, 89-97, Copyright (2008) with permission from Elsevier. Full text @ Mol. Cell Neurosci.