FIGURE

Fig. 4

ID

ZDB-FIG-080418-9

Publication

Griffin et al., 2003 - Interplay between FGF, one-eyed pinhead, and T-box transcription factors during zebrafish posterior development

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Fig. 4

Spt and ntl mutant embryos are hypersensitive to FGFR inhibition. (A?C) Embryos from ntl/+ adults. (A) Myosin staining in an untreated ntl mutant embryo. (B) Presumptive ntl mutant embryo treated with 4 μM SU5402; myosin staining is dramatically reduced relative to (A) and (C) ntl +/+ and +/- embryos treated with 4 μM SU5402. (D?F) Embryos obtained from spt/+ adults. (D) Untreated spt mutant embryos have patchy myosin staining in the trunk and segmented staining in the tail. (E) spt mutant embryos treated with 7 μM SU5402 are almost devoid of myosin staining, whereas (F) spt +/+ and +/- embryos treated with 7 μM SU5402 appear similar to untreated wild-type embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 264(2), Griffin, K.J. and Kimelman, D., Interplay between FGF, one-eyed pinhead, and T-box transcription factors during zebrafish posterior development, 456-466, Copyright (2003) with permission from Elsevier. Full text @ Dev. Biol.