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Fig. 3

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ZDB-FIG-080418-8

Publication

Griffin et al., 2003 - Interplay between FGF, one-eyed pinhead, and T-box transcription factors during zebrafish posterior development

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Fig. 3

Effect of the FGFR inhibitor SU5402 on posterior development in wild-type and ace/fgf8 mutant embryos. (A?D and F) Wild-type and (E and G) ace mutant embryos. All embryos are 24?32 h, anterior to the left. Embryos are stained with an antibody to detect myosin, except E?G, which are unstained. (A?D) Increasing the concentration of SU5402 led to a dose-dependent loss in muscle staining, beginning with the tail. Only tail muscle defects were observed at 15 μM, whereas trunk and tail muscle defects were observed at 30 μM. (E?G) Embryos from obtained from ace/+ adults. (E) Untreated ace mutant embryo, showing typically good posterior development. (F) Wild-type embryo from ace/+ parents treated with 5 μM Su5402; (G) ace mutant embryo treated with 5 μM SU5402 showing severe posterior defects.

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Acknowledgments

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Reprinted from Developmental Biology, 264(2), Griffin, K.J. and Kimelman, D., Interplay between FGF, one-eyed pinhead, and T-box transcription factors during zebrafish posterior development, 456-466, Copyright (2003) with permission from Elsevier. Full text @ Dev. Biol.