FIGURE

Fig. 5

ID

ZDB-FIG-080411-13

Publication

Chen et al., 2008 - Liver-specific expression of p53-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish

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Fig. 5

Morphological analysis of chronic disease in Gmdm2-liver#1 and 2 transgenic zebrafish with different levels of eating disorders and illness. A,B: Gross appearance of 10-month-old male Gmdm2-liver#1 with small liver polyps (A) and liver cysts (B). C-E: Liver agenesis in a Gmdm2-liver#2 transgenic zebrafish with severe emaciation (C). Macroscopic appearance of the stomach region (abdominal chamber) in the dissected whole body of 4-month-old male G-liver#1 and Gmdm2-liver #2 fish. Whole liver lobes were absent in the abdominal chamber of the Gmdm2-liver#2 fish compared with the liver of G-liver fish (D, E). Bright field image of the livers (C); GFP fluorescent image of the same livers (D); merge image of the same livers (E). F,G: Histological cross-sections from G-liver in C (F) and Gmdm2-liver#2 in C (G). Scale bars = 20 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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