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Fig. 5

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ZDB-FIG-071204-24

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Yokoi et al., 2007 - Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships

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Fig. 5

The expression of fgf8 and the phenotype of fgf8-morphant. Medaka fgf8 is expressed in the anterior tip of the forebrain, MHB, hindbrain and tailbud (A, B). The expression of fgf8 is largely unaffected in the fgfr1^hdf mutant, except for the expression in tailbud (C, D; arrows). Injection of fgf8 morpholino causes somite-less phenotype, phenocopying the fgfr1^hdf mutant phenotype (E, G). Same as fgfr1^hdf, morphology of the brain including MHB is normal in the fgf8 morphant (H). The expression of krox20 and ntl in wild-type (I, J) and fgf8 morphant (K, L). In the morphant, the expression of krox20 in r5 is lost at st. 18, and is recovered at st. 20 (K, L; arrows). The expression of pax2 and ntl in wild-type (M, N) and fgf8 morphant (O, P). The expression of pax2 in MHB is not affected in the morphant.

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Reprinted from Developmental Biology, 304(1), Yokoi, H., Shimada, A., Carl, M., Takashima, S., Kobayashi, D., Narita, T., Jindo, T., Kimura, T., Kitagawa, T., Kage, T., Sawada, A., Naruse, K., Asakawa, S., Shimizu, N., Mitani, H., Shima, A., Tsutsumi, M., Hori, H., Wittbrodt, J., Saga, Y., Ishikawa, Y., Araki, K., and Takeda, H., Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships, 326-337, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.