FIGURE

Fig. 2

ID

ZDB-FIG-070823-22

Publication

Carl et al., 2007 - Wnt/Axin1/beta-Catenin Signaling Regulates Asymmetric Nodal Activation, Elaboration, and Concordance of CNS Asymmetries

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

The mbl Mutation Can Activate Epithalamic Nodal Pathway Genes Epistatic to Loss of Spw Activity (A) The graph illustrates the percentage of embryos with wild-type (WT) left, reversed (rev) right, bilateral (bil), or not visible (nv) Nodal pathway gene expression in the epithalamus of wild-type (mbl sib) mbl (mbl^tm213/tm213), spw morphant (MoSpw/mbl sib), and mbl;spw morphant (MoSpw/mbl) embryos. The knockdown of Spw function results in the absence of lft1 and pitx2 expression only in the presence of wild-type Axin1. (B–E) Frontal views of the epithalamus (dorsal to the top) of 24s stage wild-type (mbl sib) mbl, spw morphant (MoSpw/mbl sib), and mbl;spw morphant (MoSpw/mbl) embryos analyzed for lft1 expression.

Expression Data

Gene:	lft1
Fish:	WT axin1^tm213/tm213 WT + MO1-spaw axin1^tm213/tm213 + MO1-spaw
Knockdown Reagent:	MO1-spaw
Anatomical Term:	epithalamus
Stage:	20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	axin1^tm213/tm213 WT + MO1-spaw axin1^tm213/tm213 + MO1-spaw
Knockdown Reagent:	MO1-spaw
Observed In:	determination of left/right symmetry
Stage:	20-25 somites

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Neuron