FIGURE

Fig. 3

ID

ZDB-FIG-060522-17

Publication

Wang et al., 2006 - Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation

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Fig. 3

Genetic interaction between Dvl2 and Lp and reduced length-to-width ratio (LWR) in Lp/Lp and Dvl2^-/-; Lp/+ embryos during neurulation. (A) Similar to Dvl1^-/-; Dvl2^-/- embryos, Lp/Lp mutants displayed significant reduction of LWR during neurulation, while Lp/+ embryos displayed intermediate reduction. At the eight-somite stage, some of the neural folds were already apposed and started to fuse at the dorsal midline in wild-type embryos (B). Parallel to the reduction of LWR, however, the neural folds were still open in Lp/+ embryos (C) and widely apart in Lp/Lp embryos (D) of the same somite stage. Similar to both Dvl1^-/-; Dvl2^-/- and Lp/Lp mutants, all Dvl2^-/-; Lp/+ embryos also displayed significant reduction of LWR during neurulation (E). From a cross between Dvl1^+/-; Dvl2^+/-; Lp/+ and Dvl2^-/- mice, all progeny that were Dvl2^-/- or Dvl1^+/-; Dvl2^-/- (F) displayed normal neural tube closure at E10.5. By contrast, all Dvl1^+/-; Dvl2^-/-; Lp/+ and Dvl2^-/-; Lp/+ embryos displayed craniorachischisis (G). The error bars represent s.d.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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