FIGURE

Fig. 2

ID

ZDB-FIG-060522-16

Publication

Wang et al., 2006 - Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation

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Fig. 2

In situ hybridization analysis of Brachyury (T) in early headfold stage Dvl1^-/-; Dvl2^-/- and Lp/Lp mutant embryos. (A) T, a known downstream target gene of the canonical Wnt pathway, was expressed in the notochord, node and primitive streak in control embryos (Dvl1^-/-; Dvl2^+/-). (B) In Dvl1^-/-; Dvl2^-/- mutants, T expression in the node and primitive streak was maintained, suggesting normal activity of the Wnt pathway. However, T expression in the notochord was abnormally widened. T-positive cells were also observed outside of the notochord (arrows), consistent with a disruption of cell movement towards the central midline. Compared with wild-type littermates (C), T expression was also widened in the notochord of Lp/Lp embryos (D). T-positive cells were also observed outside of the notochord (D, arrows).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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