CRISPR

CRISPR2-stab1

ID

ZDB-CRISPR-221031-1

Name

CRISPR2-stab1

Previous Names

None

Target

stab1 (1)

Sequence

5' - AAATTGGCGGTCGCC - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
ibl3	stab1

Expression

Gene expression in Wild Types + CRISPR2-stab1

No data available

Phenotype

Phenotype resulting from CRISPR2-stab1

No data available

Phenotype of all Fish created by or utilizing CRISPR2-stab1

Phenotype	Fish	Conditions	Figures
scavenger receptor activity disrupted, abnormal	stab1^ibl3/ibl3	standard conditions	Fig. 2 from Arias-Alpizar et al., 2021
blood vessel endothelial cell receptor-mediated endocytosis involved in cholesterol transport decreased process quality, abnormal	stab1^ibl3/ibl3 (AB/TL)	control	Fig. 1 from Verwilligen et al., 2022
kidney decreased functionality, abnormal	stab1^ibl3/ibl3; stab2^ibl2/ibl2	standard conditions	Fig. 1 from Arias-Alpizar et al., 2021
whole organism semi-viable, abnormal	stab1^ibl3/ibl3; stab2^ibl2/ibl2	standard conditions	Fig. 1 from Arias-Alpizar et al., 2021
scavenger receptor activity disrupted, abnormal	stab1^ibl3/ibl3; stab2^ibl2/ibl2	standard conditions	Fig. 2 , Fig. 3 from Arias-Alpizar et al., 2021
whole organism ldlra expression increased amount, abnormal	stab1^ibl3/ibl3; stab2^ibl2/ibl2 (AB/TL)	high cholesterol	Fig. 4 from Verwilligen et al., 2022
whole organism cd36 expression decreased amount, abnormal	stab1^ibl3/ibl3; stab2^ibl2/ibl2 (AB/TL)	high cholesterol	Fig. 4 from Verwilligen et al., 2022
whole organism scarb1 expression decreased amount, abnormal	stab1^ibl3/ibl3; stab2^ibl2/ibl2 (AB/TL)	high cholesterol	Fig. 4 from Verwilligen et al., 2022
whole organism marco expression increased amount, abnormal	stab1^ibl3/ibl3; stab2^ibl2/ibl2 (AB/TL)	standard conditions	Fig. 3 from Verwilligen et al., 2022
blood vessel endothelial cell receptor-mediated endocytosis involved in cholesterol transport process quality, exacerbated	stab1^ibl3/ibl3; stab2^ibl2/ibl2 (AB/TL)	control	Fig. 1 from Verwilligen et al., 2022
blood vessel endothelial cell low-density lipoprotein particle clearance decreased process quality, abnormal	stab1^ibl3/ibl3; stab2^ibl2/ibl2; gl23Tg (AB/TL)	control	Fig. 2 from Verwilligen et al., 2022
blood vessel endothelial cell oxidised low-density lipoprotein particle clearance decreased process quality, abnormal	stab1^ibl3/ibl3; stab2^ibl2/ibl2; gl23Tg (AB/TL)	control	Fig. 2 from Verwilligen et al., 2022

Citations