CRISPR

CRISPR2-esrp2

ID

ZDB-CRISPR-211103-2

Name

CRISPR2-esrp2

Previous Names

None

Target

esrp2 (1)

Sequence

5' - GTGCAAATGGGGGTAAACTG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Genome Build: GRCz11Chromosome: 7

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
fb402	esrp2

Expression

Gene expression in Wild Types + CRISPR2-esrp2

No data available

Phenotype

Phenotype resulting from CRISPR2-esrp2

No data available

Phenotype of all Fish created by or utilizing CRISPR2-esrp2

Phenotype	Fish	Conditions	Figures
Meckel's cartilage transformed to ceratohyal cartilage, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402	standard conditions	Fig. 1 , Fig. 2 , Fig. 6 from Caetano da Silva et al., 2024
ceratobranchial 5 tooth decreased amount, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402	standard conditions	Fig. 1 from Caetano da Silva et al., 2024
pectoral fin curled, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402	standard conditions	Fig. 6 from Caetano da Silva et al., 2024
pectoral fin mesenchyme sox10 expression decreased amount, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402	standard conditions	Fig. 1 from Caetano da Silva et al., 2024
pectoral fin epithelial cell krt4 expression spatial pattern, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402	standard conditions	Fig. 1 from Caetano da Silva et al., 2024
pectoral fin epithelial cell krt4 expression decreased amount, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402	standard conditions	Fig. 1 from Caetano da Silva et al., 2024
pectoral fin mesenchyme sox10 expression spatial pattern, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402	standard conditions	Fig. 1 from Caetano da Silva et al., 2024
otolith fused with otolith, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402	standard conditions	Fig. 1 , Fig. 6 from Caetano da Silva et al., 2024
Meckel's cartilage morphology, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402 (TU)	standard conditions	Fig. 5. from Carroll et al., 2020
parasphenoid cleft, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402 (TU)	standard conditions	Fig. 5. from Carroll et al., 2020
neurocranium cranial neural crest cell undifferentiated, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402 (TU)	standard conditions	Fig. 8. from Carroll et al., 2020
upper lip structurally discontinuous, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402 (TU)	standard conditions	Fig. 5. from Carroll et al., 2020
keratinocyte morphology, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402 (TU)	standard conditions	Fig. 5. from Carroll et al., 2020
neuromast absent, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402 (TU)	standard conditions	Fig. 5. from Carroll et al., 2020
parasphenoid increased width, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402 (TU)	standard conditions	Fig. 5. from Carroll et al., 2020
neurocranium anterior region cleft, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402 (TU)	standard conditions	Fig. 5. from Carroll et al., 2020
neurocranium epithelial cell mislocalised, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402 (TU)	standard conditions	Fig. 8. from Carroll et al., 2020
neurocranium chondrocyte absent, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402 (TU)	standard conditions	Fig. 7. from Carroll et al., 2020
neurocranium cartilage element sox10 expression increased distribution, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402 (TU)	standard conditions	Fig. 8. from Carroll et al., 2020
epithelial cell irf6 expression spatial pattern, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402 (TU)	standard conditions	Fig. 8. from Carroll et al., 2020
neurocranium cranial neural crest cell undifferentiated, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402; zf393Tg (TU)	standard conditions	Fig. 6. from Carroll et al., 2020
neurocranium chondrocyte absent, abnormal	esrp1^fb401/fb401; esrp2^fb402/fb402; zf393Tg (TU)	standard conditions	Fig. 6. from Carroll et al., 2020

Citations

Include unpublished citations

Carroll, S.H., Macias Trevino, C., Li, E.B., Kawasaki, K., Myers, N., Hallett, S.A., Alhazmi, N., Cotney, J., Carstens, R.P., Liao, E.C. (2020) An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Development (Cambridge, England). 147(24):

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