CRISPR

CRISPR2-cntn1b

ID

ZDB-CRISPR-210218-3

Name

CRISPR2-cntn1b

Previous Names

None

Target

cntn1b (1)

Sequence

5' - TCTGGACACTGTGTACGCGG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
tum204	cntn1b

Expression

Gene expression in Wild Types + CRISPR2-cntn1b

No data available

Phenotype

Phenotype resulting from CRISPR2-cntn1b

No data available

Phenotype of all Fish created by or utilizing CRISPR2-cntn1b

Phenotype	Fish	Conditions	Figures
spinal cord myelin sheath surrounding spinal cord neuronal cell body, abnormal	cntn1b^{tum204/tum204}; ue2Tg	standard conditions	Fig. 1 from Djannatian et al., 2019
spinal cord central nervous system myelin formation decreased process quality, abnormal	cntn1b^{tum204/tum204}; ue2Tg	standard conditions	Fig. 1 from Djannatian et al., 2019
spinal cord regulation of myelination decreased spatial extent of a process, abnormal	cntn1b^{tum204/tum204}; mag^{tum201/tum201}	standard conditions	Fig 4 from Radha et al., 2026
oligodendrocyte cell death increased occurrence, abnormal	cntn1b^{tum204/tum204}; mag^{tum201/tum201}	standard conditions	Fig 3 from Radha et al., 2026
Mauthner neuron axon increased size, abnormal	cntn1b^{tum204/tum204}; mag^{tum201/tum201}	standard conditions	Fig 4 from Radha et al., 2026
spinal cord myelin sheath decreased length, abnormal	cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg	standard conditions	Fig. 2 from Djannatian et al., 2019
spinal cord central nervous system myelin formation decreased process quality, abnormal	cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg	standard conditions	Fig. 2 , Fig. 4 from Djannatian et al., 2019
spinal cord central nervous system myelin formation decreased process quality, exacerbated	cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg	standard conditions	Fig. 2 from Djannatian et al., 2019
spinal cord myelin sheath decreased length, exacerbated	cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg	standard conditions	Fig. 2 from Djannatian et al., 2019
oligodendrocyte filamentous actin spatial pattern, abnormal	cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg	standard conditions	Fig. 3 from Djannatian et al., 2019
spinal cord myelin sheath EGFP expression decreased amount, abnormal	cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg/ue2Tg	standard conditions	Fig 1 from Radha et al., 2026
spinal cord myelin sheath EGFP expression decreased distribution, abnormal	cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg/ue2Tg	standard conditions	Fig 1 from Radha et al., 2026
spinal cord myelination decreased occurrence, abnormal	cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg/ue2Tg	standard conditions	Fig 1 from Radha et al., 2026
oligodendrocyte cell death increased occurrence, exacerbated	cadm4^{tum208/tum208}; cntn1b^{tum204/tum204}; mag^{tum201/tum201}	standard conditions	Fig 3 from Radha et al., 2026
oligodendrocyte myelin assembly decreased process quality, abnormal	cadm4^{tum208/tum208}; cntn1b^{tum204/tum204}; mag^{tum201/tum201}	standard conditions	Fig 2 from Radha et al., 2026
spinal cord regulation of myelination decreased spatial extent of a process, exacerbated	cadm4^{tum208/tum208}; cntn1b^{tum204/tum204}; mag^{tum201/tum201}	standard conditions	Fig 4 from Radha et al., 2026
Mauthner neuron axon increased size, exacerbated	cadm4^{tum208/tum208}; cntn1b^{tum204/tum204}; mag^{tum201/tum201}	standard conditions	Fig 4 from Radha et al., 2026
spinal cord myelination decreased spatial extent of a process, exacerbated	cadm4^{tum208/tum208}; cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg/ue2Tg	standard conditions	Fig 2 from Radha et al., 2026
whole organism cadm4 expression decreased amount, abnormal	cadm4^{tum208/tum208}; cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg/ue2Tg	standard conditions	Fig. S2 from Radha et al., 2026
spinal cord myelin sheath EGFP expression decreased amount, abnormal	cadm4^{tum208/tum208}; cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg/ue2Tg	standard conditions	Fig 1 , Fig 2 from Radha et al., 2026
spinal cord myelin sheath EGFP expression decreased distribution, abnormal	cadm4^{tum208/tum208}; cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg/ue2Tg	standard conditions	Fig 1 , Fig 2 from Radha et al., 2026
whole organism cadm3 expression decreased amount, abnormal	cadm4^{tum208/tum208}; cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg/ue2Tg	standard conditions	Fig. S2 from Radha et al., 2026
whole organism cadm1b expression decreased amount, abnormal	cadm4^{tum208/tum208}; cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg/ue2Tg	standard conditions	Fig. S2 from Radha et al., 2026
spinal cord myelination decreased occurrence, exacerbated	cadm4^{tum208/tum208}; cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg/ue2Tg	standard conditions	Fig 1 from Radha et al., 2026
whole organism cadm2a expression decreased amount, abnormal	cadm4^{tum208/tum208}; cntn1b^{tum204/tum204}; mag^{tum201/tum201}; ue2Tg/ue2Tg	standard conditions	Fig. S2 from Radha et al., 2026

Citations