CRISPR

CRISPR2-ptgs2a

ID

ZDB-CRISPR-190814-2

Name

CRISPR2-ptgs2a

Previous Names

None

Target

ptgs2a (1)

Sequence

5' - CAACAGCATCTCTTACCTGAGGG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Genome Build: GRCz11Chromosome: 2

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
zf3102	ptgs2a

Expression

Gene expression in Wild Types + CRISPR2-ptgs2a

No data available

Phenotype

Phenotype resulting from CRISPR2-ptgs2a

No data available

Phenotype of all Fish created by or utilizing CRISPR2-ptgs2a

Phenotype	Fish	Conditions	Figures
retina photoreceptor connecting cilium ab1-tuba labeling decreased distribution, abnormal	ptgs1^{zf3101/zf3101}; ptgs2a^{zf3102/zf3102} + MO1-ptgs2b	standard conditions	Fig. 2 from Li et al., 2019
red sensitive photoreceptor cell zpr-1 labeling decreased distribution, abnormal	ptgs1^{zf3101/zf3101}; ptgs2a^{zf3102/zf3102} + MO1-ptgs2b	standard conditions	Fig. 4 from Li et al., 2019
retinal cone cell Ab1-opn1lw labeling absent, abnormal	ptgs1^{zf3101/zf3101}; ptgs2a^{zf3102/zf3102} + MO1-ptgs2b	standard conditions	Fig. 2 from Li et al., 2019
photoreceptor inner segment layer decreased length, abnormal	ptgs1^{zf3101/zf3101}; ptgs2a^{zf3102/zf3102} + MO1-ptgs2b	standard conditions	Fig. 4 from Li et al., 2019
retinal rod cell ab5-rho labeling absent, abnormal	ptgs1^{zf3101/zf3101}; ptgs2a^{zf3102/zf3102} + MO1-ptgs2b	standard conditions	Fig. 2 from Li et al., 2019
green sensitive photoreceptor cell decreased amount, abnormal	ptgs1^{zf3101/zf3101}; ptgs2a^{zf3102/zf3102} + MO1-ptgs2b	standard conditions	Fig. 4 from Li et al., 2019
red sensitive photoreceptor cell decreased amount, abnormal	ptgs1^{zf3101/zf3101}; ptgs2a^{zf3102/zf3102} + MO1-ptgs2b	standard conditions	Fig. 4 from Li et al., 2019
green sensitive photoreceptor cell zpr-1 labeling decreased distribution, abnormal	ptgs1^{zf3101/zf3101}; ptgs2a^{zf3102/zf3102} + MO1-ptgs2b	standard conditions	Fig. 4 from Li et al., 2019
retina photoreceptor connecting cilium decreased length, abnormal	ptgs1^{zf3101/zf3101}; ptgs2a^{zf3102/zf3102} + MO1-ptgs2b	standard conditions	Fig. 2 from Li et al., 2019

Citations

Include unpublished citations

Li, W., Jin, D., Zhong, T.P. (2019) Photoreceptor cell development requires prostaglandin signaling in the zebrafish retina. Biochemical and Biophysical Research Communications. 510(2):230-235

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