CRISPR

CRISPR1-mipb

ID

ZDB-CRISPR-181017-5

Name

CRISPR1-mipb

Previous Names

None

Target

mipb (1)

Sequence

5' - GGGGGCCATGGCAGGAGCCG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Genome Build: GRCz11Chromosome: 23

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
ir1091	mipb

Expression

Gene expression in Wild Types + CRISPR1-mipb

No data available

Phenotype

Phenotype resulting from CRISPR1-mipb

No data available

Phenotype of all Fish created by or utilizing CRISPR1-mipb

Phenotype	Fish	Conditions	Figures
lens fiber cell mipb expression absent, abnormal	mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 1 , Fig. 5 from Vorontsova et al., 2018
lens central region refractivity, abnormal	mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 2 from Vorontsova et al., 2018
lens opacity, abnormal	mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 8 from Wang et al., 2021
lens lens development in camera-type eye decreased process quality, abnormal	mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 2 from Vorontsova et al., 2018
lens central region opaque, abnormal	mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 2 from Vorontsova et al., 2018
lens decreased diameter, abnormal	mipa^{ir1090/ir1090}; mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 1 from Wang et al., 2021
lens central region refractivity, abnormal	mipa^{ir1090/ir1090}; mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 2 from Vorontsova et al., 2018
lens anterior region opaque, abnormal	mipa^{ir1090/ir1090}; mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 3 from Vorontsova et al., 2018
lens fiber cell lens fiber cell morphogenesis decreased process quality, abnormal	mipa^{ir1090/ir1090}; mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 7 from Vorontsova et al., 2018
lens lens morphogenesis in camera-type eye decreased process quality, abnormal	mipa^{ir1090/ir1090}; mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 6 from Vorontsova et al., 2018
lens opaque, abnormal	mipa^{ir1090/ir1090}; mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 3 from Vorontsova et al., 2018
lens opacity, abnormal	mipa^{ir1090/ir1090}; mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 9 , Fig. 10 from Wang et al., 2021
lens refractivity, abnormal	mipa^{ir1090/ir1090}; mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 4 , Fig. 5 from Wang et al., 2021 Fig. 4 from Vorontsova et al., 2018
lens lens development in camera-type eye decreased process quality, abnormal	mipa^{ir1090/ir1090}; mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 2 , Fig. 3 , Fig. 4 from Vorontsova et al., 2018
lens central region opaque, abnormal	mipa^{ir1090/ir1090}; mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 2 , Fig. 4 from Vorontsova et al., 2018
lens malformed, abnormal	mipa^{ir1090/ir1090}; mipb^{ir1091/ir1091} (AB)	standard conditions	Fig. 6 from Vorontsova et al., 2018

Citations

Include unpublished citations

Vorontsova, I., Gehring, I., Hall, J.E., Schilling, T.F. (2018) Aqp0a Regulates Suture Stability in the Zebrafish Lens. Investigative ophthalmology & visual science. 59:2869-2879

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