header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-050706-86
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Gene Name: major intrinsic protein of lens fiber b
Gene Symbol: mipb
Sequence Ontology ID : SO:0001217

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: mip2, aqp0b (1), zgc:110015

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 23 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits water transmembrane transporter activity. Involved in lens development in camera-type eye. Predicted to localize to the integral component of membrane and plasma membrane. Human ortholog(s)  ...
GENE EXPRESSION
All Expression Data: 9 figures from 6 publications
Wild-type Stages, Structures: Segmentation:26+ somites (22.0h-24.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ir1091 Small Deletion Unknown Unknown CRISPR
sa12858 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Targeting reagents:
    PHENOTYPE
    Data: 5 figures from 3 publications
    Observed in:
    DISEASE ASSOCIATED WITH mipb HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    cataract 15 multiple types Cataract 15, multiple types 615274
    DISEASE ASSOCIATED WITH mipb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lens fiber cell morphogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function NOT   water channel activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000425 (1)
  • InterPro:IPR022357 (1)
  • InterPro:IPR023271 (1)
  • InterPro:IPR034294 (1)
  • PROSITE:PS00221 (1)
  • Pfam:PF00230 (1)
    • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA mipb-201 (1) 2138
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mipb No data available
    MARKER RELATIONSHIPS
    mipb Contained in: [BAC] CH211-147F12 (1) (order this)
    mipb Encodes: [cDNA] MGC:110015 (1) (order this), MGC:173554 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020520 (1) 2146 bp
    Select Tool
    Genomic GenBank:CR450824 (1) 170611 bp
    Select Tool
    Polypeptide UniProtKB:A9JRM7 (1) 263 aa
    Select Tool
    Sequence Clusters UniGene:87423 (1)
    Sequence Information (all 18)
    OTHER mipb GENE PAGES
  • Alliance (1)
  • Gene:553420 (1)
  • VEGA:OTTDARG00000021068 (1)
  • Ensembl(GRCz11):ENSDARG00000013963 (1)
    • ORTHOLOGY for mipb ( Chr: 23 )
    CITATIONS (30)