Gene
mipb
- ID
- ZDB-GENE-050706-86
- Name
- major intrinsic protein of lens fiber b
- Symbol
- mipb Nomenclature History
- Previous Names
-
- mip2
- aqp0b (1)
- zgc:110015
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables water transmembrane transporter activity. Acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules; lens fiber cell morphogenesis; and maintenance of lens transparency. Predicted to be located in anchoring junction and membrane. Predicted to be active in plasma membrane. Is expressed in eye; lens; lens fiber cell; and solid lens vesicle. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human MIP (major intrinsic protein of lens fiber).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mipb | (4) | |
| CRISPR2-mipb | He et al., 2023 | |
| MO1-mipb | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cataract 15 multiple types | Alliance | Cataract 15, multiple types | 615274 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Aquaporin-like | Aquaporin transporter | Major intrinsic protein | Major intrinsic protein, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:Q4ZJI3 | InterPro | 263 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-147F12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110015 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173554 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020520 (1) | 2146 nt | ||
| Genomic | GenBank:CR450824 (1) | 110034 nt | ||
| Polypeptide | UniProtKB:Q4ZJI3 (1) | 263 aa |
- Safrina, O., Vorontsova, I., Donaldson, P.J., Schilling, T.F. (2024) Zebrafish Optical Development Requires Regulated Water Permeability by Aquaporin 0. Investigative ophthalmology & visual science. 65:4242
- He, M., Zhou, G., Lin, Q., Zhou, N. (2023) The role of mip in the development of lens in zebrafish. Gene expression patterns : GEP. 49:119330
- Vorontsova, I., Vallmitjana, A., Torrado, B., Schilling, T.F., Hall, J.E., Gratton, E., Malacrida, L. (2022) In vivo macromolecular crowding is differentially modulated by aquaporin 0 in zebrafish lens: Insights from a nanoenvironment sensor and spectral imaging. Science advances. 8:eabj4833
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Vorontsova, I., Hall, J.E., Schilling, T.F., Nagai, N., Nakazawa, Y. (2021) Differences in a Single Extracellular Residue Underlie Adhesive Functions of Two Zebrafish Aqp0s. Cells. 10(8):
- Wang, K., Vorontsova, I., Hoshino, M., Uesugi, K., Yagi, N., Hall, J.E., Schilling, T.F., Pierscionek, B.K. (2021) Aquaporins Have Regional Functions in Development of Refractive Index in the Zebrafish Eye Lens. Investigative ophthalmology & visual science. 62:23
- Posner, M., McDonald, M.S., Murray, K.L., Kiss, A.J. (2019) Why does the zebrafish cloche mutant develop lens cataract?. PLoS One. 14:e0211399
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
- Krall, M., Htun, S., Anand, D., Hart, D., Lachke, S.A., Slavotinek, A.M. (2018) A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans. Human genetics. 137(4):315-328
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