Gene

mipb

ID

ZDB-GENE-050706-86

Name

major intrinsic protein of lens fiber b

Symbol

mipb Nomenclature History

Previous Names

mip2
aqp0b (1)
zgc:110015

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Exhibits water transmembrane transporter activity. Involved in lens fiber cell morphogenesis. Predicted to localize to integral component of membrane and plasma membrane. Is expressed in eye; lens; lens fiber cell; and solid lens vesicle. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human MIP (major intrinsic protein of lens fiber).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mipb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cataract 15 multiple types	Alliance	Cataract 15, multiple types	615274

Associated With mipb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR022357	Major intrinsic protein, conserved site
Family	IPR000425	Major intrinsic protein
Family	IPR034294	Aquaporin transporter
Homologous_superfamily	IPR023271	Aquaporin-like