CRISPR

CRISPR2-cryabb

ID

ZDB-CRISPR-180521-6

Name

CRISPR2-cryabb

Previous Names

T02 (1)

Target

cryabb (1)

Sequence

5' - CTCCCCAAATTGCCGGCG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Genome Build: GRCz11Chromosome: 5

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
vu613	cryabb

Expression

Gene expression in Wild Types + CRISPR2-cryabb

No data available

Phenotype

Phenotype resulting from CRISPR2-cryabb

No data available

Phenotype of all Fish created by or utilizing CRISPR2-cryabb

Phenotype	Fish	Conditions	Figures
pericardium edematous, abnormal	cryabb^vu613/vu613 (AB)	chemical treatment by environment: cortisol	Fig. 5 from Mishra et al., 2018
heart contraction process quality, abnormal	cryabb^vu613/vu613 (AB)	chemical treatment by environment: dexamethasone	Fig. 5 from Mishra et al., 2018
heart contraction decreased rate, abnormal	cryabb^vu613/vu613 (AB)	chemical treatment by environment: dexamethasone	Fig. 5 from Mishra et al., 2018
lens morphology, exacerbated	cryabb^vu613/vu613 (AB)	stress	Fig. 4 from Mishra et al., 2018
heart contraction decreased rate, abnormal	cryabb^vu613/vu613 (AB)	control	Fig. 5 from Mishra et al., 2018
pericardium edematous, abnormal	cryabb^vu613/vu613 (AB)	stress	Fig. 4 from Mishra et al., 2018
cardiac ventricle dilated, abnormal	cryabb^vu613/vu613 (AB)	chemical treatment by environment: dexamethasone	Fig. 5 from Mishra et al., 2018
lens morphology, abnormal	cryabb^vu613/vu613 (AB)	control	Fig. 3, Fig. 4, Fig. 6 from Mishra et al., 2018
pericardium edematous, abnormal	cryabb^vu613/vu613 (AB)	chemical treatment by environment: dexamethasone	Fig. 5 from Mishra et al., 2018
atrium dilated, abnormal	cryabb^vu613/vu613 (AB)	chemical treatment by environment: dexamethasone	Fig. 5 from Mishra et al., 2018
pericardium edematous, abnormal	cryaba^vu612/vu612; cryabb^vu613/vu613 (AB)	chemical treatment by environment: cortisol	Fig. 5 from Mishra et al., 2018
pericardium edematous, abnormal	cryaba^vu612/vu612; cryabb^vu613/vu613 (AB)	chemical treatment by environment: dexamethasone	Fig. 5 from Mishra et al., 2018
lens morphology, abnormal	cryaba^vu612/vu612; cryabb^vu613/vu613 (AB)	control	Fig. 3 from Mishra et al., 2018
lens morphology, ameliorated	cryabb^vu613/vu613; vu614Tg	control	Fig. 6 from Mishra et al., 2018
lens morphology, exacerbated	cryaba^vu612/vu612; cryabb^vu613/vu613; vu617Tg	control	Fig. 5 from Wu et al., 2018

Citations

Include unpublished citations

Mishra, S., Wu, S.Y., Fuller, A.W., Wang, Z., Rose, K.L., Schey, K.L., Mchaourab, H.S. (2018) Loss of αB-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart. The Journal of biological chemistry. 293(2):740-753

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