Gene

cryabb

ID
ZDB-GENE-040718-419
Name
crystallin, alpha B, b
Symbol
cryabb Nomenclature History
Previous Names
  • cryab2
  • fe37f08
  • hspb5b (1)
  • wu:fe37f08
  • zgc:91937
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Enables unfolded protein binding activity. Acts upstream of or within several processes, including heart contraction; maintenance of lens transparency; and myofibril assembly. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; heart; lens; liver; and otic vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAB (crystallin alpha B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cryabb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
adult-onset myofibrillar myopathy 2A Alliance Myopathy, myofibrillar, 2A, adult-onset 608810
cataract 16 multiple types Alliance Cataract 16, multiple types 613763
dilated cardiomyopathy 1II Alliance Cardiomyopathy, dilated, 1II 615184
infantile-onset myofibrillar myopathy-2B Alliance Myopathy, myofibrillar, 2B, infantile-onset 613869
Associated With cryabb Via Experimental Models
Human Disease Fish Conditions Citations
cataract cryabbasu3/asu3 standard conditions Posner et al., 2024
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002068 Alpha crystallin/Hsp20 domain
Domain IPR003090 Alpha-crystallin, N-terminal
Family IPR001436 Alpha crystallin/Small heat shock protein, animal type
Homologous_superfamily IPR008978 HSP20-like chaperone
Domain Details Per Protein
Protein Additional Resources Length Alpha crystallin/Hsp20 domain Alpha-crystallin, N-terminal Alpha crystallin/Small heat shock protein, animal type HSP20-like chaperone
UniProtKB:A0A8M9Q8E3 InterPro 180
UniProtKB:Q6DG35 InterPro 165
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cryabb-201 (1) Ensembl 1,003 nt
mRNA cryabb-202 (1) Ensembl 952 nt
mRNA cryabb-203 (1) Ensembl 2,192 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations