Gene

cryabb

ID

ZDB-GENE-040718-419

Name

crystallin, alpha B, b

Symbol

cryabb Nomenclature History

Previous Names

cryab2
fe37f08
hspb5b (1)
wu:fe37f08
zgc:91937

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Exhibits unfolded protein binding activity. Involved in several processes, including heart contraction; myofibril assembly; and skeletal muscle tissue development. Is expressed in several structures, including brain; heart; lens; liver; and otic vesicle. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAB (crystallin alpha B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 14 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

MGC:91937 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cryabb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cataract 16 multiple types	Alliance	Cataract 16, multiple types	613763
dilated cardiomyopathy 1II	Alliance	Cardiomyopathy, dilated, 1II	615184
fatal infantile hypertonic myofibrillar myopathy	Alliance	Myopathy, myofibrillar, fatal infantile hypertonic, alpha-B crystallin-related	613869
myofibrillar myopathy 2	Alliance	Myopathy, myofibrillar, 2	608810

Associated With cryabb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002068	Alpha crystallin/Hsp20 domain
Domain	IPR003090	Alpha-crystallin, N-terminal
Family	IPR001436	Alpha crystallin/Small heat shock protein, animal type
Homologous_superfamily	IPR008978	HSP20-like chaperone

Domain Details Per Protein

Protein	Length	Alpha crystallin/Hsp20 domain	Alpha-crystallin, N-terminal	Alpha crystallin/Small heat shock protein, animal type	HSP20-like chaperone
UniProtKB:A0A0R4IY19 InterPro	124
UniProtKB:A0A0R4IG31 InterPro	180
UniProtKB:Q6DG35 InterPro	165

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	cryabb-201 (1) Ensembl	1003 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cryabb-202 (1) Ensembl	952 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cryabb-203 (1) Ensembl	2192 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations