Genomic Feature
tc300a
- ID
- ZDB-ALT-980203-1750
- Name
- tc300a
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (2)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 45898583 (GRCz11) (1) Details
- Nucleotide change
- T/G
- Variant Notes
-
TGT->TGG
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>G (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Cys>Trp (1)
- Flanking Sequence
-
GAGGTGTTCAGGCCAGCTTTGGCCCCCTCCAAAGAGCCTCTAACCAGACTTCTGGACACCCGTCTGGTGCAGGACTCTCACACGCGCTGGGAAAGCTTCGACGTGGGTTCAGCTGTGGCACGCTGGGCCCGCGAATCCCAGCACAACCATGGGCTCCTTGTAGAGGTGCTCCATCCTAAGGAGTCAGAAGTATCCGAGGAGGCTGAGAGCAACCGGAGGAAGCACGTGAGGGTCAGTCGTTCCCTTCACGCGGATGAGGACTCGTGGGCACAAGCCCGACCTCTGCTGGTAACCTACAGCCATGACGGTCAAGGCACAGCCGTCTTGCATTCGAACCGAGAAAAGCGGCAGGCTCGACGAGGGCAAAAGCCGAGGAGAAAGCACCACCAGCGCTCGAACTGTAGGCGACATGCTCTCTATGTGGACTTCAGTGATGTCGGCTGGAACGAGTGGATCGTGGCACCGCCAGGCTATCATGCTTTCTACTGCCATGGCGAGTG
T/G CCGTTCCCTCTGCCGGACCATCTAAACTCCACCAACCATGCCATTGTCCAGACGCTGGTGAACTCGGTCAACTCCAACATTCCCAAAGCCTGTTGCATCCCGACGGAGCTCAGCCCTATCTCACTGCTGTACCTGGACGAGTACGAGAAGGTCATTCTTAAAAACTACCAGGACATGGTGGTGGAGGGCTGCGGTTGCCGATGAGAACAATCTCCCCAATGAAGACTTTTATTTATACAAAAGAGCGAGCTATTTTGGAGGAAGAAAAGAAATATATATGAATATATTTATGTTGAATGAACAAAACAAAAAAAATGGGAAAATAAATATTTTAATGAGAGTGCTTGCTTTTTCCAGTGGCTTCGAAGATGATTTTTTTTCTTGCCCCATTCCAAAACAAGTGCAATGGCACATGAAGTATAATGCTCAGATTTTTATGATGTATTTATTGCATAACCACTTTATTTGTAAATGTGTATTTATCATGAAAAAATATATGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| bmp2btc300a/tc300a | Homozygous | ♀+/- ♂+/- | 6 figures  from 3 publications | text only from Grinblat et al., 2001 | |
| bmp2btc300a/tc300a | Homozygous | ♀-/- ♂-/- | |||
| bmp2btc300a/tc300a (TU) | Homozygous | ♀+/- ♂+/- | 4 figures from 4 publications | 11 figures from 8 publications | |
| bmp2btc300a/+ (AB) | Heterozygous | Unknown | |||
| bmp2btc300a/+; bmp7asb1aub/+ | Complex | Fig. 7 from Schmid et al., 2000 | |||
| bmp2btc300a/tc300a; bmp7asb1aub/sb1aub | Complex | text only from Grinblat et al., 2001 | text only from Grinblat et al., 2001 | ||
| bmp2btc300a/tc300a; chrdtt250/+ (AB) | Complex | Fig. 4 from Gonzalez et al., 2000 | Fig. 4 from Gonzalez et al., 2000 | ||
| bmp2btc300a/tc300a + MO1-twsg1b (TU) | Complex | Fig. 3 from Little et al., 2004 | |||
| bmp2btc300a/+ + MO3-wnt8a + MO4-wnt8a + MO5-wnt8a + MO6-wnt8a (TU) | Complex | Fig. 1 from Ramel et al., 2005 | |||
| bmp2btc300a/tc300a + MO3-wnt8a + MO4-wnt8a + MO5-wnt8a + MO6-wnt8a (TU) | Complex | Fig. 1 from Ramel et al., 2005 | 2 figures from Ramel et al., 2005 |
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Supplemental Information
- Genotyping protocol
- tc300a.pdf
- Čapek, D., Safroshkin, M., Morales-Navarrete, H., Toulany, N., Arutyunov, G., Kurzbach, A., Bihler, J., Hagauer, J., Kick, S., Jones, F., Jordan, B., Müller, P. (2023) EmbryoNet: using deep learning to link embryonic phenotypes to signaling pathways. Nature Methods. 20(6):815-823
- Soh, G.H., Pomreinke, A.P., Müller, P. (2020) Integration of Nodal and BMP Signaling by Mutual Signaling Effector Antagonism. Cell Reports. 31:107487
- Pomreinke, A.P., Soh, G.H., Rogers, K.W., Bergmann, J.K., Bläßle, A.J., Müller, P. (2017) Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning. eLIFE. 6
- Kruse-Bend, R., Rosenthal, J., Quist, T.S., Veien, E.S., Fuhrmann, S., Dorsky, R.I., and Chien, C.B. (2012) Extraocular ectoderm triggers dorsal retinal fate during optic vesicle evagination in zebrafish. Developmental Biology. 371(1):57-65
- Schumacher, J.A., Hashiguchi, M., Nguyen, V.H., and Mullins, M.C. (2011) An Intermediate Level of BMP Signaling Directly Specifies Cranial Neural Crest Progenitor Cells in Zebrafish. PLoS One. 6(11):e27403
- Wise, S.B., and Stock, D.W. (2010) bmp2b and bmp4 are dispensable for zebrafish tooth development. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(10):2534-2546
- Hammond, K.L., Loynes, H.E., Mowbray, C., Runke, G., Hammerschmidt, M., Mullins, M.C., Hildreth, V., Chaudhry, B., and Whitfield, T.T. (2009) A late role for bmp2b in the morphogenesis of semicircular canal ducts in the zebrafish inner ear. PLoS One. 4(2):e4368
- Bae, Y.K., Shimizu, T., and Hibi, M. (2005) Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm. Development (Cambridge, England). 132(6):1375-1385
- Ramel, M.C., Buckles, G.R., Baker, K.D., and Lekven, A.C. (2005) WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation. Developmental Biology. 287(2):237-248
- Waxman, J.S. (2005) Regulation of the early expression patterns of the zebrafish Dishevelled-interacting proteins Dapper1 and Dapper2. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(1):194-200
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