Genomic Feature
tz216
- ID
- ZDB-ALT-980203-1671
- Name
- tz216
- Synonyms
-
- AZ016A (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
European Zebrafish Resource Center (EZRC)
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China Zebrafish Resource Center (CZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 5: 36515987 (GRCz11) (1) Details
- Nucleotide change
- G/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Gly>Stop at position 155 (1)
- Flanking Sequence
-
CATAGTATTTTTCTACTATGAATTTCAATAGTTAACAACTGATTTCCAACATTTTTCTAATTATCTTCTTTTCTGTTTAATGGAAAAGCAAAATGCATTTTAGTATAATTTTAGTATTTGGGTGATTCCATTAGGACAGATGTGAACAAACAAATAAAAAGGAAAAATACCAGCAGAGTCCAACAGCATCAGGTTTTATTGTTATCATTATAACAATTAAAAAGTACAAAACCATTAGAATGTTTGTGATGGTTTCCAATAGGTTTTTTTTAAGCATGGGAGTATCATCTGTTTGTGTTCAGCTTTTAGATGTATGATAGAAACTGATGATCTAACAGTGTGGTCTCTGTGCAGGGACCCGTGAGGCAGCGTTTGTGTTTTCTCTGGCTGCTGCGGTGGTCAGTCATGCCATAGCTCGTGCCTGTGCATCTGGAGACCTGCCCAGCTGTTCCTGTGCTGCAATGCCGTCAGAGCAGGCGGCTCCTGATTTCCGCTGGGGT
G/T GATGTGGAGATAACCTTCGCTACGGCCTACAGATGGGCTCCGCTTTCTCAGATGCACCAATAAGGAACCGGCGCTCGGGCCCACAGGCCTTTAGACTCATGCAGCTTCACAACAATGCTGTTGGCAGACAGGTAAAGCCTCAACCACATGCTGGATTTCCACAGAAGACTGGCATCATTCACTGTAGACATAGCAGGGTTCCATTCAATTCATTCAGGTTGTCTCAACACAAATCTATTAGGTGACTTAACAATCTGAGTAGATTGAACATAAAACAATCGTTGTCCCAAACATAAAACAACAAGTTGTCCCAAAAAATCTTAAGAGTTGTGTTGATTAAGCTCATTTTACATAAGTAGCATGAACAGGTCACAGTAAATTAATAATGAAAATAGTAATTATTTTTTTGAGTGTTTCGATCAGTATCATGAATCTGTGTGTTCGTGTTTGTAAAGGTGCTTATGGACTCTCTAGAGATGAAGTGCAAATGTCATGGCGTT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| wnt11f2tz216/tz216 | Homozygous | Unknown | 9 figures  from 5 publications | 4 figures from 2 publications | |
| wnt11f2tz216/tz216 | Homozygous | ♀+/- ♂+/- | 4 figures from 4 publications | 2 figures from 2 publications | |
| wnt11f2tz216/tz216 | Homozygous | ♀-/- | Fig. 4 from Liu et al., 2017 | ||
| wnt11f2tz216/tz216 (AB) | Homozygous | Unknown | Fig. 5 from Angonin et al., 2013 | ||
| wnt11f2tz216/tz216 (AB) | Homozygous | ♀-/- ♂-/- | Fig. 7 from Van Raay et al., 2007 | 3 figures from Van Raay et al., 2007 | |
| wnt11f2tz216/+ (AB) | Heterozygous | Unknown | |||
| wnt11f2tz216/tz216 + MO1-adgra3 | Complex | Fig. 2 from Li et al., 2013 | |||
| wnt11f2tz216/tz216 + MO2-adgra3 | Complex | Fig. 2 from Li et al., 2013 | |||
| gpc4m119/m119; wnt11f2tz216/tz216 | Complex | Fig. 6 from Topczewski et al., 2001 | |||
| wnt11f2tz216/tz216 + MO2-nkd1 (AB) | Complex | Fig. 8 from Van Raay et al., 2007 | Fig. 8 from Van Raay et al., 2007 |
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Supplemental Information
- Genotyping protocol
- None
- Hu, B., Rodriguez, J.J., Kakkerla Balaraju, A., Gao, Y., Nguyen, N.T., Steen, H., Suhaib, S., Chen, S., Lin, F. (2021) Glypican 4 mediates Wnt transport between germ layers via signaling filopodia. The Journal of cell biology. 220(12):
- Navajas Acedo, J., Voas, M.G., Alexander, R., Woolley, T., Unruh, J.R., Li, H., Moens, C., Piotrowski, T. (2019) PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation. Nature communications. 10:3993
- Liu, Y., Sepich, D.S., Solnica-Krezel, L. (2017) Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation. PLoS Genetics. 13:e1006564
- Sisson, B.E., Dale, R.M., Mui, S.R., Topczewska, J.M., Topczewski, J. (2015) A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis. Mechanisms of Development. 138 Pt 3:279-90
- Angonin, D., and Van Raay, T.J. (2013) Nkd1 functions as a passive antagonist of wnt signaling. PLoS One. 8(8):e74666
- Li, X., Roszko, I., Sepich, D.S., Ni, M., Hamm, H.E., Marlow, F.L., and Solnica-Krezel, L. (2013) Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Development (Cambridge, England). 140(14):3028-3039
- Flowers, G.P., Topczewska, J.M., and Topczewski, J. (2012) A zebrafish Notum homolog specifically blocks the Wnt/beta-catenin signaling pathway. Development (Cambridge, England). 139(13):2416-2425
- Lou, Q., He, J., Hu, L., and Yin, Z. (2012) Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish. Biochimica et biophysica acta. Molecular cell research. 1823(5):1024-1032
- Sisson, B.E., and Topczewski, J. (2009) Expression of five frizzleds during zebrafish craniofacial development. Gene expression patterns : GEP. 9(7):520-527
- Muyskens, J.B., and Kimmel, C.B. (2007) Tbx16 cooperates with Wnt11 in assembling the zebrafish organizer. Mechanisms of Development. 124(1):35-42
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