Genomic Feature
ty17a
- ID
- ZDB-ALT-980203-1384
- Name
- ty17a
- Synonyms
-
- Y017A (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 9: 37294312 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T at position 3445 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Glu>Stop at position 1032 (1)
- Flanking Sequence
-
CAGCCACTGGGGGTGCACCACCAACACCTCTGCCCAACATGGATCGCATGAGCCTTAAAACTAGAATGGCCATGTACAATGACTCGCAGGACAGTTCAGCACATTTGCACCATGCCCAAGGTGTAGTCAACTCAAGACGCTGCAGCGACACTGGGTACGGTGCCCCTGGCATAATGCCTCATGAAGTTCCGGCCAATCTTCCACGACGAGCAAGCGATCCTGTTCGTCGTACAACTCTTGACCCACTCTCCTTGCCAAGAGTTCAGCGGTTCAACAGCATCAGCAACATGAACCTATCACGTCTGCCTGCATATGATCGACGTGCTTTCAACATGCAGAACAACACTTGGTCTGATGGAAGCTTGCACCGTCATCCCTTCAGCCAAAGGCCACCTAGCATATCAGAGAACATTTTAATGGAAAATATGGCCACTGATGGAGGAGATCAACAAGGGGATGATTTGGTGCTTCCCGATGACATGGTACAGTACCTCAGGTCC
C/T AGAATGGTAACTCAAATCACGATTCTGGGATTTCTGTCAATGGCGGTCATGCTCTAGAGTTCCATGGTAATATGACCTCCCAACAACAACAGTTCTATGGGCAACGCAGAATGGGCATGGCAAGCATCAATGGAAGTCACGTAGAGCCTGTTCCAGAACAAATAGCTGATCCGCAGGGCATGAACAAAAACAACATGCCTGTGCAGTGGAATGAGGTCAGTTCTGGTTCTGCAGATGCAGTTTCAAGGGTTCCAAAGCAACAGCAACAACAACTCAGAGGGAACTTGACAGTTGTTCAGCAGAAGCAGAACTTTGGCTCTTATCAAGGATTTGGATCAAACCAGCAGATTGTACCAATGAGCCAGAATCTGGCTAGTCTACAGCAGGCTTATCCACAGAGAAACATCCAGAGGATGAACACTGTCCAGCAGTATCGCCAGTCCATTTCCAATCCATGTCAGAATATCGGTGAGCAAGTAAACCGGCAGGACCTTAGTTAC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| gli2aty17a/ty17a | Homozygous | ♀+/- ♂+/- | 15 figures  from 10 publications | 14 figures from 10 publications | |
| gli2aty17a/ty17a (AB) | Homozygous | ♀+/- ♂+/- | Fig. 3 from Paulus et al., 2009 | ||
| gli2aty17a/+ | Heterozygous | ♀+/- ♂+/- | Fig. 4 from Schafer et al., 2007 | 2 figures from Schafer et al., 2007 | |
| gli2aty17a/ty17a + MO1-gli2a | Complex | Fig. 3 from Devine et al., 2009 | |||
| gli2aty17a/ty17a + MO1-gli2b | Complex | 2 figures from Ke et al., 2008 | 2 figures from Ke et al., 2008 | ||
| gli2aty17a/ty17a + MO1-rest | Complex | Fig. 7 from Gates et al., 2010 |
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Supplemental Information
- Genotyping protocol
- None
- Milla, L.A., Cortes, C.R., Hodar, C.Q., Onate, M.G., Cambiazo, V., Burgess, S.M., and Palma, V. (2012) Yeast-based assay identifies novel Shh/Gli target genes in vertebrate development. BMC Genomics. 13(1):2
- Feijoo, C.G., Oñate, M.G., Milla, L.A., and Palma, V.A. (2011) Sonic hedgehog (Shh)-Gli signaling controls neural progenitor cell division in the developing tectum in zebrafish. The European journal of neuroscience. 33(4):589-598
- Mich, J.K., and Chen, J.K. (2011) Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish. Development (Cambridge, England). 138(23):5113-5119
- Gates, K.P., Mentzer, L., Karlstrom, R.O., and Sirotkin, H.I. (2010) The transcriptional repressor REST/NRSF modulates hedgehog signaling. Developmental Biology. 340(2):293-305
- Devine, C.A., Sbrogna, J.L., Guner, B., Osgood, M., Shen, M.C., and Karlstrom, R.O. (2009) A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary. Developmental Biology. 326(1):143-154
- Paulus, J.D., Willer, G.B., Willer, J.R., Gregg, R.G., and Halloran, M.C. (2009) Muscle contractions guide Rohon-Beard peripheral sensory axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(42):13190-13201
- Guner, B., Ozacar, A.T., Thomas, J.E., and Karlstrom, R.O. (2008) Graded hedgehog and fibroblast growth factor signaling independently regulate pituitary cell fates and help establish the pars distalis and pars intermedia of the zebrafish adenohypophysis. Endocrinology. 149(9):4435-4451
- Ke, Z., Kondrichin, I., Gong, Z., and Korzh, V. (2008) Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment. Molecular and cellular neurosciences. 37(2):388-401
- Guner, B., and Karlstrom, R.O. (2007) Cloning of zebrafish nkx6.2 and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube. Gene expression patterns : GEP. 7(5):596-605
- Schafer, M., Kinzel, D., and Winkler, C. (2007) Discontinuous organization and specification of the lateral floor plate in zebrafish. Developmental Biology. 301(1):117-129
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