Genomic Feature
te273
- ID
- ZDB-ALT-980203-1237
- Name
- te273
- Synonyms
-
- AE073A (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 3: 54617418 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- None
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Arg>Cys at position 167 (1)
- Flanking Sequence
-
TCTGCCGCAATTGAGCAGCCCCCAGCAACACAGGACCCTCAAGAACTCCTTCCTCATGTCCTTACTCCGCAAGGTGTAGATCAACGGGTTCAGTGCCGAATTCAGTGTGGCAAAGCTGAAGAAGATGCCAGCGTTATTGAGGATAGGGCATTGCTTCATCTTGCAGGAAGTGTCCAGGAGGAGGATGGTGAAGGCAGGCAGCCAACAGATGATGAAGACGCCAAGGACAATTGTGACCGTCTTCAGGAGAGCATACGCTGGAGAATTGGTGGCCTCTTGGTGGCTGGTGCGCACAATGAGATAGATGCGAACGTAAAGGATCACGATGGACAGCAAGATGATGCTAAAGATGGTGACAACAAACCGGATGTAGTATCGGGTGTTGAGGGGCAAAACAGCTGAGCAATCATCCAGGTTATTAATACAGTTCCAACCTATAATAGGAAGACCTCCTAGAAGAATGGACATCACCCAGCATGCTCCGATCAGAAGAAACATGC
G/A GCACGTTTTGTTGGATCCGTAAACCTTGACCTTGGTGATGGCGATGTAGCGCTCGATAGCAATAGCCAGCAGGCTGAAAACGGAGGCGGACAAAGCAATGAAAGCAGTCCCCTCTCGTATGAACCACTGGACAGGAGTCAAATGAAATGTCCTAGGGCCAGACAGGAAGATGTTGGCAATGTATGCAGAGCCAGCTAGTAGGTCCGAGAAGGCCAGGTTCCCAATGAAGAAGAACATGGCTGAGTGGAACTTTTTATTCCTAAACACAGCGATGAGCACTAGGAGGTTTTCCAAGATGATGATGCTGCAGATTACGACAAATAAAATGTTCAGGGAGCTCAAGCTTTGTTTGCTCTCGATGCGGTCTCTTAGTTCCTCTGCGGTCATCTCCTTAGCAGTGAGATAGTGGACCTGGATGAGGGTCTTGTTGAAGTACTGGGAGTATTTGCTCATGGTGACAGCTTGGCAAAACCCCGCAAACAGACGGCAAGTAGTCATTC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| s1pr2te273/te273 | Homozygous | ♀+/- ♂+/- | 4 figures  from 4 publications | 2 figures from 2 publications | |
| s1pr2te273/+ (AB) | Heterozygous | Unknown | |||
| s1pr2te273/te273; twu34Tg | Complex | ||||
| s1pr2te273/te273; twu34Tg/twu34Tg | Complex | Fig. 2 from Matsui et al., 2007 | |||
| s1pr2te273/te273; twu34Tg/twu34Tg + MO4-fn1a | Complex | Fig. 2 from Matsui et al., 2007 | |||
| npas4ls5/s5; s1pr2te273/te273; twu34Tg | Complex | Fig. 4 from Holtzman et al., 2007 | |||
| s1pr2te273/te273; spint1ahi2217Tg/hi2217Tg | Complex | Fig. 6 from Armistead et al., 2020 |
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Supplemental Information
- Genotyping protocol
- te273.pdf
- Mahabaleshwar, H., Asharani, P.V., Loo, T.Y., Koh, S.Y., Pitman, M.R., Kwok, S., Ma, J., Hu, B., Lin, F., Li Lok, X., Pitson, S.M., Saunders, T.E., Carney, T.J. (2022) Slit-Robo signalling establishes a Sphingosine-1-phosphate gradient to polarise fin mesenchyme. EMBO reports. 23(8):e54464
- Armistead, J., Hatzold, J., van Roye, A., Fahle, E., Hammerschmidt, M. (2020) Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase. The Journal of cell biology. 219(2):
- Holtzman, N.G., Schoenebeck, J.J., Tsai, H.J., and Yelon, D. (2007) Endocardium is necessary for cardiomyocyte movement during heart tube assembly. Development (Cambridge, England). 134(13):2379-2386
- Matsui, T., Raya, A., Callol-Massot, C., Kawakami, Y., Oishi, I., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2007) miles-apart-Mediated regulation of cell-fibronectin interaction and myocardial migration in zebrafish. Nature clinical practice. Cardiovascular medicine. 4(1):S77-S82
- Matsui, T., Raya, A., Kawakami, Y., Callol-Massot, C., Capdevila, J., Rodriguez-Esteban, C., Izpisúa Belmonte, J.C. (2005) Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes & Development. 19(1):164-175
- Ciruna, B., Weidinger, G., Knaut, H., Thisse, B., Thisse, C., Raz, E., and Schier, A.F. (2002) Production of maternal-zygotic mutant zebrafish by germ-line replacement. Proceedings of the National Academy of Sciences of the United States of America. 99(23):14919-14924
- David, N.B., Saint-Etienne, L., Tsang, M., Schilling, T.F., and Rosa, F.M. (2002) Requirement for endoderm and FGF3 in ventral head skeleton formation. Development (Cambridge, England). 129(19):4457-4468
- Kupperman, E., An, S., Osborne, N., Waldron, S., and Stainier, D.Y. (2000) A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development. Nature. 406(6792):192-195
- Chen, J.N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development (Cambridge, England). 123:293-302
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
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