Genomic Feature
nz207
- ID
- ZDB-ALT-210819-3
- Name
- nz207
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Crosier Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 14: 28495891 - 28495897 (GRCz11) (1) Details
- Nucleotide change
- AAGGGAA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 7 bp deleted in Exon 3 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CACCACCAGCTAAAATGTGGCAAGAATTGTTTTCATGTATGGGCGATATATATTGCGTCACCAAAAATGATTGCGGTCATGGCCATGTATTGTGCGATAAGTCAATATATAGATTATTGTGACAGACCTATTCATGTTGAAGTTGCATTTTTAGGTTGACTAGTTAAACATACAAGAAAAAAATATATAAATAGTTATCAAGTCAGCCAAGTGATCAGATTTTTGTTAATTTATTTTTTTGCCAAATTGCTCTGATTTAGCTTCTTGTGACGCTTTAGTGGGAATATTTAAATAAATAAATAACGAAATGACTCCTACCAGTCAGTTACACATATAAATGATACTTGTAGCTTGGGAATCTTATTTGTTATGGAAGACATCCTGTCCTCCATTTGCTGACTGTTTTTTTTCACTTGCTGAGAGTTTGATCCATTTCTTTTCTGTTGACCTGTGATGTCACTCTGCTTCAGGCGAAGAAAGGAAAGAAGGGCCCTGGAGAG
AAGGGAA/- AAGGGATGGGTAAAGGAGTTGGACGCATGAACGGTCACCACCAGGAAAACGGCATGGAAAATGTCATGCTTTTTGAAGTGGTCAGGCTGGGGAAGAGTGCCATGCAGGTCAGTGAGCATAATACCAGCTTTTACACTACCCTCTGTCTCGCTCTGGCATTCACATCTTAAATTCTCTCATGTGTGTTTTGGGGCTTCTGGAGGGACCGGAGCTTTGGCAGGAGAATATGCAGACAGCTGTACCGCTGGGTAGTCCAGCAGATTTTGACCTTTGAGAAATTTCTGCTCTCTGTTTTGCAGTCGGTCGTCGATGACTGGATCGAGTCTTATAAACATGACCGAGACGTCGCACTCCTCGACTTGATCAATTTCTTCATCCAGTGCTCCGGCTGCAAAGGTTTGAATGGCATTTCTCGTGTTATCTGGGTTGAGATTGTAGATTGTAAATGTCATGTGACATAATCAAGATGGTAACTGGTGTCGTTTATCATAAGATAAAAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| stag2bnz207/nz207 (WIK) | Homozygous | ♀-/- ♂-/- | 3 figures  from Ketharnathan et al., 2020 | 5 figures from Ketharnathan et al., 2020 | |
| stag2bnz207/+ (WIK) | Heterozygous | Unknown | Figure 3 from Ketharnathan et al., 2020 | Figure 3 from Ketharnathan et al., 2020 | |
| stag2bnz207/nz207; ia5Tg/+ | Complex | Figure 7. from Chin et al., 2020 | Figure 7. from Chin et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Labudina, A.A., Meier, M., Gimenez, G., Tatarakis, D., Ketharnathan, S., Mackie, B., Schilling, T.F., Antony, J., Horsfield, J.A. (2024) Cohesin composition and dosage independently affect early development in zebrafish. Development (Cambridge, England). 151(15):
- Chin, C.V., Antony, J., Ketharnathan, S., Labudina, A., Gimenez, G., Parsons, K.M., He, J., George, A.J., Pallota, M.M., Musio, A., Braithwaite, A.W., Guilford, P., Hannan, R.D., Horsfield, J.A. (2020) Cohesin mutations are synthetic lethal with stimulation of WNT signaling. eLIFE. 9:
- Ketharnathan, S., Labudina, A., Horsfield, J.A. (2020) Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Frontiers in cell and developmental biology. 8:617545
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