Genomic Feature
bns208
- ID
- ZDB-ALT-210726-3
- Name
- bns208
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
-
Notes
| Comment | Citation |
|---|---|
| homozygotes die at ~ 6 dpf | Carlantoni et al., 2020 |
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 6: 33994539 - 33994545 (GRCz11) (1) Details
- Nucleotide change
- CCAACGG/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 7 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
GGTGAGCCTCAAAATCACTGGGATTTGGGTCCTATTTTAACATCAGGAAATTCTAAAAAGAGACTATTGTCTTTATGTCACTCTAATATGGCAGTGGACACTATACATACACTGTTCTGTCCAATCAGCTTTAAAAAGTTGATTTTCATCATAGGTGATCTTTAAACACTGAAAAATGATCAAACTACACTAAAAAATGCTGGGTTGTTTCACCTCAAATTAGGGTCAAATGTGGATGAACCCAGCTGTTGAGTTAAAAATATAGTTTAACCTAGCAGTTGAGTTTGTCCATATGCAATCCAAATTTAAAGTGACCCAGCATTTTGTAGAGTCTAAAGTAATGACATGTCTACTTACAGATCCAGACTGATAGGTGAATGTCCGTCTTCTTTTAAGGACAGATTTACGAATGTAAAAGAGGGCCAGAAGAGCCAGTAGAATGGTCACACAAGTCACAGCCACTGACCCAACCACAGCAAAAAGAAGTTGATGATCCTCAG
CCAACGG/- CCGTCCCACTTGCTGAGTGGTGGGAATAAAGCTGGATAATCCTGATACATGGGAAATTAAGGAAGGACAATAAGAAGGACAATAAGAAAACAAATTTATGTTGTTATTTCAGTATTTTCTCCTAGTCTCCTACCTTCTCCAGGTGTCTGAGCTTGTACGAAGCTGCTCCACTCTCCAGGTACCTTAGAGAAAGCTCTCACTCTGAATTGGTACAATGTGCTCCCATTGAGGGATGTTACATCTTTTGTGGTTTTGTTGCCATTGTCTGTGTCTACCCAAGGATGCAAGCTGCTCTGGCCCACTGGCTGGTATTCAATGCTGTATTTTACAATGCCTCCATTGGGATCTTCAGGTGGCTGCCAGCGAAGCCTGACTGCACTAATGGACAGGGCGTCGGCCTGGACGTTTCGTGGAGAAGAAGGGCCTGGAGAGGAATCATACACAATTTTACTATTCCAGTTTAATTGAACAGTATAGTATGCATATTTGCTTCATTACAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| tie1bns208/bns208 | Homozygous | ♀+/- ♂+/- | |||
| tie1bns208/bns208; f2Tg; y7Tg | Complex | Fig. 3 from Carlantoni et al., 2020 | Fig. 3 from Carlantoni et al., 2020 | ||
| tie1bns208/bns208; s843Tg | Complex | 3 figures from Carlantoni et al., 2020 | 3 figures from Carlantoni et al., 2020 | ||
| tie1bns208/bns208; s883Tg | Complex | Fig. 4 from Carlantoni et al., 2020 | Fig. 4 from Carlantoni et al., 2020 | ||
| tie1bns208/bns208; sd10Tg | Complex | Fig. 4 from Carlantoni et al., 2020 | Fig. 4 from Carlantoni et al., 2020 | ||
| tie1bns208/bns208; y7Tg | Complex | Fig. 2 from Carlantoni et al., 2020 | Fig. 2 from Carlantoni et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Pham, V.C., Rödel, C.J., Valentino, M., Malinverno, M., Paolini, A., Münch, J., Pasquier, C., Onyeogaziri, F.C., Lazovic, B., Girard, R., Koskimäki, J., Hußmann, M., Keith, B., Jachimowicz, D., Kohl, F., Hagelkruys, A., Penninger, J.M., Schulte-Merker, S., Awad, I.A., Hicks, R., Magnusson, P.U., Faurobert, E., Pagani, M., Abdelilah-Seyfried, S. (2024) Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations. EMBO Molecular Medicine. 16(11):2827-2855
- Hußmann, M., Schulte, D., Weischer, S., Carlantoni, C., Nakajima, H., Mochizuki, N., Stainier, D.Y.R., Zobel, T., Koch, M., Schulte-Merker, S. (2023) Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner. eLIFE. 12:
- Carlantoni, C., Allanki, S., Kontarakis, Z., Rossi, A., Piesker, J., Günther, S., Stainier, D.Y.R. (2020) Tie1 regulates zebrafish cardiac morphogenesis through tolloid-like 1 expression. Developmental Biology. 469:54-67
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