Genomic Feature
ihb408
- ID
- ZDB-ALT-200609-4
- Name
- ihb408
- Synonyms
-
- M1L1 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Zhan Yin Lab
- Current Source
- China Zebrafish Resource Center (CZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 17: 33227642 - 33227649 (GRCz11) (1) Details
- Nucleotide change
- GAGACCTC/-
- Variant Notes
-
GTTGGGAAAATGCCCGCTGTC - - - - - - - - AGCACAGAGGAGAACATCTTGGTG
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: 171 AA missing (1)
- Flanking Sequence
-
AGACTCTCAGAGAGAACAACTTTGGTTACTGACTTCTTTCTGTGCAAAAGGTGGGTGAAAAATATCCCATACACTAAAATAATCTGGATTGTTTTCTTCAAAAAATTGGACAAACTGAACAGTTGGGATTGGACAAACTGAACAGTTGGGATTTGTAACTGAACTATTGGGTTATTTGATTCAAATGTTGAGTTAAAACTAACAGATTTTTTATTGATTTGTCTTTTTTGCATATCAGATAATTCATTTAATTGATGTATTTTATTACTTTGAAGTATTATTTCATACTTTCCAACTGTTCTTTCAACTGTAGTGTGCAAACAAATGTGTTTTGAGAGTCTACAATATGAATTTAACATGCTTAAATGTGAATTGTATTGTGTTCTCAGAGATGGTGAGGGGAGTGAGGATGTTGTGTCCTGCTTGGCTCTTGGCTCTGGCTGTTCTCTGCGCAGGAGGATCTGAAGTCAGAGCTCAGTGTTGGGAAAATGCCCGCTGTC
GAGACCTC/- AGCACAGAGGAGAACATCTTGGTGAGTTGCTGGATTCGTCACGGCTTAGATTAATTGCTGATCCTTTACTATTATTATTTTAGATGTTCTGTGCTCTGTAAGTTACATTGTAAGTAACTCCCATTAGAAAATTAGACGTGTACAGTAAGTGCAGAGTTATAATCAGTAAAAATGTCTGTTGGGCAACTATCATTAAAATAATAATTGCTTAATATTTTGTTGATTAAATGGTTGAACAGACTTGTTTTGGGGCTGAACTTTTGGCTTTTTTTTTGTTTGTTTTCTTTTCTTTTTTTTTTTTAGTTGATCATTTGTGACCATAGACTTTAAAACCAGTCATTAACATAGGTATATAATATTTGGCTCAGAAACAACTATTTGAAAATCTGGAATCTTGTGGATTAAAATACAGAAAAAAAAAATATTAAAATTGAGTTTTGATATATTTTAAGTACACTCTCAGAAATAAAGGTACAGGAGCTGTCACTGGGGCAGTACCT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| pomcaihb408/ihb408 | Homozygous | ♀+/- ♂+/- | 6 figures from Shi et al., 2019 | 4 figures from Shi et al., 2019 | |
| pomcaihb408/ihb408 (AB) | Homozygous | ♀+/- ♂+/- | Figure 2  from Shi et al., 2022 | Figure 2 from Shi et al., 2022 | |
| pomcaihb408/ihb408; zf44Tg | Complex | ||||
| cyp17a1ihb144/ihb144; pomcaihb408/ihb408 | Complex | Fig. 6 from Shi et al., 2019 | |||
| cyp17a2zf3680/zf3680; pomcaihb408/ihb408 (AB) | Complex | Figure 2 from Shi et al., 2022 | Figure 2 from Shi et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Shi, S., Shu, T., Li, X., Lou, Q., Jin, X., He, J., Yin, Z., Zhai, G. (2022) Characterization of the Interrenal Gland and Sexual Traits Development in cyp17a2-Deficient Zebrafish. Frontiers in endocrinology. 13:910639
- Shi, C., Lu, Y., Zhai, G., Huang, J., Shang, G., Lou, Q., Li, D., Jin, X., He, J., Du, Z., Gui, J., Yin, Z. (2019) Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity. Journal of molecular cell biology. 12(4):291-304
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