Genomic Feature
li14
- ID
- ZDB-ALT-190528-9
- Name
- li14
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Englert Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 18: 45612111 - 45612115 (GRCz11) (1) Details
- Nucleotide change
- CGTAA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 5 bp deleted in Exon 2 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
AACCCATGACTGGAAACATTCATACTCACTCATTCACACACATACACTACGGACAATTTAGTTTATTCAATTCACCAATAGCGCATGTGTTTGGAATGAGGGAAACTGGAGCTCCAGGAGGAAACCCCGTTCTCCCTGTGTTGACGACGTGGGTTTCCTCCAGGTGCTCTGGTTTTCCCCACAGTCCAAACACATGAGCTTTAGGTGAAGTGGATTAACTAAATTGGCTGTAGTTTATGTGTGTATGGGTGTGTATGGGTGTTTCCCAGTACTGGGTTGCAGCTAGAACGCTGTGTAAAACATATGCTGATTTAGTTGGCGGTTCATTCTGCTGTGGCAACCGCTGATGAATAAAGGGACTAACCCGAACGAAAATTAATGATGAATATTACAGTGCATGCTGTACTGTTCCTACCCATGGTGCTTTGCGGAGACATCGGGTCCTCGTGTTTGAAGGTGTCATTAGGGAACGGAGGAGAGTGTTGTGTAGGTGTGTGACC
CGTAA/- TGGGAATTCCGTCGACTGCTACTGTCCCATAACCTGACAGAAAAATACAACCTGTTAATGTTTGTTTACTATGGTTGAGACTCAGTTGATATACAGTTGAAGTCAGAATTATTAGACCTCCTGAATTATTAGCCTCTCTGTAAATTTGTCCCCCCAATTACTGTTTTTTTAATACACATTCCTAAACATAATAGTTTTAACAACTCATTTCTAATAACTTTTATCTTTGCTATGATGACAGTACATACTATTTGACTAGATACTTTTCTAGATACTAGTATTCAGCTTGTAGTGACATTTCAAGAGTTCACACTTAGCTGATGATTGATTTTAAAGCTTGTTTGGCATGCTGTCCCGGGAGAGAGGCCTAAGCTCATAAGATCCTCAAGCCCGGGCCTCCCTCCCATTGCAAGGCGAGAGGGGAGTTTGAGCTCAGGTAGATCTCGAGAACTCCTCTGCTGTAGTAGCTAATGAACAGATAGTGATTGCTCTTAAGAGAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| wt1bli14/li14 | Homozygous | Unknown | 2 figures  from Sanz-Morejón et al., 2019 | ||
| wt1bli14/li14 (AB/TU) | Homozygous | ♀+/- ♂+/- | FIGURE 3 from Hopfenmüller et al., 2022 | FIGURE 3 from Hopfenmüller et al., 2022 | |
| wt1bli14/+ (AB/TU) | Heterozygous | ♀+/- ♂+/- | FIGURE 3 from Hopfenmüller et al., 2022 | FIGURE 3 from Hopfenmüller et al., 2022 | |
| wt1azf3845/+; wt1bli14/li14 (AB/TU) | Complex | FIGURE 3 from Hopfenmüller et al., 2022 | FIGURE 3 from Hopfenmüller et al., 2022 | ||
| wt1azf3845/+; wt1bli14/+ (AB/TU) | Complex | FIGURE 3 from Hopfenmüller et al., 2022 | FIGURE 3 from Hopfenmüller et al., 2022 | ||
| wt1azf3845/zf3845; wt1bli14/li14 (AB/TU) | Complex | FIGURE 3 from Hopfenmüller et al., 2022 | FIGURE 3 from Hopfenmüller et al., 2022 | ||
| wt1azf3845/zf3845; wt1bli14/+ (AB/TU) | Complex | FIGURE 3 from Hopfenmüller et al., 2022 | FIGURE 3 from Hopfenmüller et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Hopfenmüller, V.L., Perner, B., Reuter, H., Bates, T.J.D., Große, A., Englert, C. (2022) The Wilms Tumor Gene wt1a Contributes to Blood-Cerebrospinal Fluid Barrier Function in Zebrafish. Frontiers in cell and developmental biology. 9:809962
- Sanz-Morejón, A., García-Redondo, A.B., Reuter, H., Marques, I.J., Bates, T., Galardi-Castilla, M., Große, A., Manig, S., Langa, X., Ernst, A., Piragyte, I., Botos, M.A., González-Rosa, J.M., Ruiz-Ortega, M., Briones, A.M., Salaices, M., Englert, C., Mercader, N. (2019) Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish. Cell Reports. 28:1296-1306.e6
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