Genomic Feature
bns89
- ID
- ZDB-ALT-171002-10
- Name
- bns89
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 13: 31772695 - 31772703 (GRCz11) (1) Details
- Nucleotide change
- CATTGAGGC/TAGAT
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 5 bp inserted / 9 bp deleted in Exon 6 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
AATACAATTGTTGATCCAATTGTTTGAGACAATAGAAAAAATAATATTATGCTTTATATTTTTATGTGTTATTATTATTATTATCAACTATTAAGCATTTCTGTGGTATCTCTTGATTGTTTTCCCTTTGTGTACCATTCAGTAATAATCTACACATCTGTAATATTACTGTAATATTTATTCCATGCGCTGCTGAAAGTAATTTGTTAATTCTACTACATTGCCTTTTGACATTATGCCGGAATAATGGCATGTCTTGTTAACAGTTTAATGGAAGTTACTCCCCTGATTCACCAAAGCATCGGGGGGTGTTGTAAATAGGTAAATGCAGTTGTCCATGGATCCATATTTATCCCTATCAGCCTCTCTCTGTGACAGGTGCTGCGCTGTTCGGGCCGTATCCACACAGCAGATGGTGTTGAGAAGGAGGTGTGTGAAGAAAAAAACACGTGTTCGACGTACCTGGTGCTCATCTGCGAGTCTATTCCCCATCCGGCGAA
CATTGAGGC/TAGAT TCCTCTGGATTCCAGAACGTTCCTCAGCCGCCACACTTTAGACATGCGCTTCACCTACTGTGATGAGAGGTAAAAGAACACCTGCACCGCTCAGCATAATATTCAGTGCTTCTGTGCTGACTGCAGCAGCATCTGACTTTTACATCTGTGTTTTTATTTTTTTATTCTTGGAGTCACAGATATGGTCCTTTTGCTTCCCATTTTCCTAAACTCTAGAGAGAGCTTCACATGTTTATATTTAAGGATAAGAATATCAAGCGTGAAATTAAATTGATTATTTTAATATACTACCATTCAAACAATTGGGGTTACAAAAATGTATTGATGCTTTTATTCAGCAAGGATGCTTTAAACTGATTAAAAGTGACAGCAAAACATTGTTACAAATTTCTCTGTATTTAGTTTATAAATGTTAAAATATGTTACAGGAACTAATTAGAGTTTAATTAGAAAAATATGAGCATTCTATTAAAATAGCTTGTGTTTTTGTTGCATTATTA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| hif1aabns89/bns89 | Homozygous | ♀+/- ♂+/- | Fig. 1  from Gerri et al., 2017 | ||
| hif1aabns89/bns89 | Homozygous | Unknown | 3 figures from Mandic et al., 2018 | ||
| hif1aabns89/bns89; s843Tg; sd2Tg | Complex | Fig. 1 from Gerri et al., 2017 | |||
| hif1abbns90/bns90; hif1aabns89/bns89 | Complex | 5 figures from 2 publications | Fig. 3 from Marín-Juez et al., 2019 | ||
| hif1abbns90/bns90; hif1aabns89/bns89 | Complex | Fig. 3 from Gerri et al., 2017 | 5 figures from 2 publications | ||
| hif1abbns90/bns90; hif1aabns89/bns89; c264Tg; gl24Tg; s843Tg | Complex | Fig. 4 from Gerri et al., 2017 | |||
| hif1abbns90/bns90; hif1aabns89/bns89; s843Tg | Complex | Fig. 2 from Gerri et al., 2017 | 2 figures from Gerri et al., 2017 | ||
| hif1abbns90/bns90; hif1aabns89/bns89; s843Tg; ump2Tg | Complex | 3 figures from Gerri et al., 2017 | 3 figures from Gerri et al., 2017 | ||
| hif1abbns90/bns90; hif1aabns89/bns89 + MO1-epas1a + MO3-epas1b | Complex | Fig. 4 from Gerri et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Mandic, M., Flear, K., Qiu, P., Pan, Y.K., Perry, S.F., Gilmour, K.M. (2022) Aquatic surface respiration improves survival during hypoxia in zebrafish (Danio rerio) lacking hypoxia-inducible factor 1-α. Proceedings. Biological sciences. 289:20211863
- Mandic, M., Bailey, A., Perry, S.F. (2021) Hypoxia inducible factor 1-α is minimally involved in determining the time domains of the hypoxic ventilatory response in adult zebrafish (Danio rerio). Respiratory Physiology & Neurobiology. 294:103774
- Joyce, W., Perry, S.F. (2020) Hypoxia inducible factor-1α knockout does not impair acute thermal tolerance or heat hardening in zebrafish. Biology letters. 16:20200292
- Mandic, M., Best, C., Perry, S.F. (2020) Loss of hypoxia-inducible factor 1α affects hypoxia tolerance in larval and adult zebrafish (Danio rerio). Proceedings. Biological sciences. 287:20200798
- Ali, Z., Cui, D., Yang, Y., Tracey-White, D., Vazquez-Rodriguez, G., Moosajee, M., Ju, R., Li, X., Cao, Y., Jensen, L.D. (2019) Synchronized tissue-scale vasculogenesis and ubiquitous lateral sprouting underlie the unique architecture of the choriocapillaris. Developmental Biology. 457(2):206-214
- Ali, Z., Mukwaya, A., Biesemeier, A., Ntzouni, M., Ramsköld, D., Giatrellis, S., Mammadzada, P., Cao, R., Lennikov, A., Marass, M., Gerri, C., Hildesjö, C., Taylor, M., Deng, Q., Peebo, B., Del Peso, L., Kvanta, A., Sandberg, R., Schraermeyer, U., Andre, H., Steffensen, J.F., Lagali, N., Cao, Y., Kele, J., Jensen, L.D. (2019) Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization. Arteriosclerosis, Thrombosis, and Vascular Biology. 39:1402-1418
- Marín-Juez, R., El-Sammak, H., Helker, C.S.M., Kamezaki, A., Mullapuli, S.T., Bibli, S.I., Foglia, M.J., Fleming, I., Poss, K.D., Stainier, D.Y.R. (2019) Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation. Developmental Cell. 51:503-515.e4
- Gerri, C., Marass, M., Rossi, A., Stainier, D.Y.R. (2018) Hif-1α and Hif-2α regulate hemogenic endothelium and hematopoietic stem cell formation in zebrafish. Blood. 131(9):963-973
- Mandic, M., Tzaneva, V., Careau, V., Perry, S.F. (2018) Hif-1α paralogs play a role in the hypoxic ventilatory response of larval and adult zebrafish (Danio rerio). The Journal of experimental biology. 222(Pt 2):
- Gerri, C., Marín-Juez, R., Marass, M., Marks, A., Maischein, H.M., Stainier, D.Y.R. (2017) Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish. Nature communications. 8:15492
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