Genomic Feature
uq7rp
- ID
- ZDB-ALT-170908-1
- Name
- uq7rp
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one insertion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Parton Lab
- Current Source
- Other Pages
Notes
| Comment | Citation |
|---|---|
| homozygotes are viable and fertile | Lim et al., 2017 |
Variants
- Variant Type
- Insertion
- Variant Location
- Chr 24: 7637721 - 7637722 (GRCz11) (1) Details
- Nucleotide change
- -/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 1 bp inserted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
CACGCAGCTGATTTGTCTGAAGGCTTTCACAGGAAAGTGTGGCATTGACGACCCAGCTCTCATGCAGTACAGACCGTCCACAGCCTGCTTGCCAGCCTCCGCTGCTCTGGCCAGATCCCAAACACACACAGAGTGAGAAACAGAGAGAAGGAGGGAGAGCAGATGTGGTGAGTGTGACAGAGGAGGGAACAGTTAGGTGAACTCTACAGAGGGGAATCCTGAGAGCAGAAAGAAAGGCGAGTGAGGACACAGAACTTCCCACAGCTTGCATCCTTCTCACATTCCACTTTTATTTTGCAAGCACGTTCAAGTTTCAAACATGGAGGTGATTGAAGACAGCCGTCTGCATCTGGAGGTGCCCGAGCTGCGCAAGTCTCTTACTGAGATCTCAGAAGATGAAATCAACCTCCCGGTCTCTGATGATGAAGACGAAGCCACCGCCGAGAACAAAGCTAAAGATGCTGCCGAGAAAGAAGAGGCTGGGGAGGGTGGCGAGATGAA
-/A TGGGGTCATGGTCCTCACGCTGCTTGACAAAATCATTGGAGCCGTTGACCAGATCCAGCAGACGCAGGCTGGGTTGGAAGCCCGTCAGCGGGACATGGAGAGATCTGTGACGGGAATCCAGGGGGAGCTCACCAAACTGTCCAAGAGCCACACCACCACAGCCAACACCGTCAATAAGATGCTGGAGAAGGTGCGTAAGGTGAGCGTGAACGTCAAGTCGGTGCGGGGGAACCTGGAGAAACAGGCTGGCCAGATCAAACGTCTGGAGAGCAACGAGAACGAGCTCCTAAAGAGAAGAAACTTTAAAGTCATGATCTATCAGGTGAGACTTGCACAGTTTAAACACAGTTAAAGTATAAAAATGTACTTGATATTACATTATCATTTCAAAAAAGAAAGACACGAAAGAGACATACAGTACAATATAAAATGAATGCAGACAGACAGCTGATAGCTCAAGTGTTTGGAGGAAATTGATAAAGCATGCTCTTATTAAAACAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| cavin1buq7rp/uq7rp | Homozygous | ♀+/- ♂+/- | 7 figures  from Lim et al., 2017 | Fig. 1 from Lim et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Wu, Y., Lim, Y.W., Stroud, D.A., Martel, N., Hall, T.E., Lo, H.P., Ferguson, C., Ryan, M.T., McMahon, K.A., Parton, R.G. (2023) Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2. Developmental Cell. 58(5):376-397.e4
- Tillu, V.A., Lim, Y.W., Kovtun, O., Mureev, S., Ferguson, C., Bastiani, M., McMahon, K.A., Lo, H.P., Hall, T.E., Alexandrov, K., Collins, B.M., Parton, R.G. (2018) A variable undecad repeat domain in cavin1 regulates caveola formation and stability. EMBO reports. 19(9):
- Lim, Y.W., Lo, H.P., Ferguson, C., Martel, N., Giacomotto, J., Gomez, G.A., Yap, A.S., Hall, T.E., Parton, R.G. (2017) Caveolae Protect Notochord Cells against Catastrophic Mechanical Failure during Development. Current biology : CB. 27(13):1968-1981.e7
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