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ZIRC
ZFIN ID: ZDB-GENE-030131-5509
Gene Name: caveolae associated protein 1b
Gene Symbol: cavin1b    Nomenclature History

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Previous Names: fd20g07, ptrf, ptrfb, wu:fd20g07, zgc:162917

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Involved in notochord development. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 4. Is expressed in blood vasculature; notochord; otic vesicle; and pharyngeal arch 3-7 skeleton. Orthologous to human CAVIN1 (caveolae associated protein 1).
Genome Resources: Alliance (1),  Gene:561082 (1),  Ensembl(GRCz11):ENSDARG00000059362 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns110 Small Deletion Unknown Premature Stop CRISPR
sa37823 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • uq7rp Insertion Unknown Frameshift, Premature Stop CRISPR
    uq8rp Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cavin1b 1
    CRISPR2-cavin1b 1
    MO1-cavin1b N/A 3
    MO2-cavin1b N/A 1
    DISEASE ASSOCIATED WITH cavin1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital generalized lipodystrophy type 4 Alliance Lipodystrophy, congenital generalized, type 4 613327
    DISEASE ASSOCIATED WITH cavin1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process notochord development (more)
    Cellular Component caveola (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR026752 (1)
  • InterPro:IPR033297 (1)
  • Pfam:PF15237 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cavin1b-201 (1)    Ensembl 1432
    cavin1b-202 (1)    Ensembl 1307
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM cavin1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:cavin1b-MYC-EGFP,myl7:EGFP) hsp70lmyl7 cavin1bEGFPMYC Danio rerio 1 1
    Tg(hsp70l:cavin1b_K291Q_K293Q_K298Q-MYC-EGFP,myl7:EGFP) hsp70lmyl7 cavin1bEGFPMYC Danio rerio 1 1
    MARKER RELATIONSHIPS
    cavin1b Contained in: [BAC] CH211-232L14 (1) (order this), DKEYP-64F6 (1)
    cavin1b Encodes: [EST] fd20g07
    [cDNA] MGC:162917 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001114549 (1) 1432 bp
    Genomic GenBank:BX294185 (1) 115427 bp
    Select Tool
    Polypeptide UniProtKB:A6NA21 (1) 454 aa
    Sequence Clusters UniGene:156899 (1)
    Sequence Information (all 18)
    ORTHOLOGY for cavin1b ( Chr: 24 )
    CITATIONS (25)