Genomic Feature
fb101
- ID
- ZDB-ALT-140623-1
- Name
- fb101
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with zinc finger nuclease
- Lab of Origin
- Langenau Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 25: 9011592 - 9011594 (GRCz11) (1) Details
- Nucleotide change
- TCA/GC
- Variant Notes
-
The mutation is: E450fsThe mutation is: E450fs
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 2 bp inserted / 3 bp deleted (1)
- Transcript Consequence
- Frameshift (1)
- Protein Consequence
- None
- Flanking Sequence
-
CAGCCGTAAGTGATCTATAGCTGATTAACCATGTGGATGCATGATAACAGCCTTCTGAACCTACAAGTAGGCCCAGAAGGCCCCTACTGGCCCACATCTATAGGCTGATAACCACTCATAATGCCCATTCAATACAGTGATAACATTTGAAACGGCTGTTTTAAAGTACTTTCCAGGCCTTGAATCCATAAGTCTGAAATTCAAATACTTTCAAGTATTTTCAACAAGAACCATGTGAAGAGAAAAGAAGAACAAATCAGTCAAAAAGTCTTCGCAGAAAGGTCTTCTTAGCTGGGGTCATCTTCAGTGAGACAGGAGCCTTGCGGTGGGTCATCTTCATTGGGACTCTCTTCACTGGTAACATCTGCTTCGGAGGAGTCATCTCCTGTTTGGGCAGGCCACCATGATCCAAGCAGAAGTACTTGCTGTTATCTTGGGAGAGTTGGAGCAGAAGGCTTTCAGGGAGCTCCATGCATTGGGCATGGACCCAGTGTCCACCT
TCA/GC CCCCTGGAGCAGAAGATCATGGCAGGTCGGGTGAGCTCAGTAGAATAGTAGGGCTCCCAGATATTGGGGTCCACCTGGCAGGACAGGCAGCACTTGATCCAGTAGCCTGTCTGAGATTCATCCTCCTCATCTTCCTCGTTATAGGTGTCGCCCTCTACATCGCTGCTATACTCCAGCTCGTGAGGCTCTCGGCCAAAGTACAGCTCCTCAGAGTCTTCCAAAGGTGCAGAGTCCTCGAAATCAGTGGACTCCTGGCTGCCTCCCTGTGCCGTAGCTTCTCCATCTTGTTCCTTCTGGAAGCTCACTTGGTAGAAATGGTAGGCTTCTGGCGGGGTCGGGTTTCCTTCTGAAGGAATTGCAACTAGAGCAGTTCCTTTGCCCAAGCTGCCACCAAACCAAGTACGACTGTGGCTGATCTCGCTGGTCCACTGTGGAGGTTCGCGAGACTCCATATGGACTCCCACATCATCCAGGCCAACGTAGGTGCACTCCATGCGCTT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| rag2fb101/fb101 | Homozygous | ♀+/- ♂+/- | |||
| rag2fb101/fb101 (AB) | Homozygous | ♀+/- ♂+/- | 3 figures  from 3 publications | ||
| rag2fb101 | Unknown | Unknown | |||
| mitfaw2; rag2fb101/fb101; mpv17a9; cz1Tg; umc13Tg | Complex | Fig. 2 from Dee et al., 2016 | |||
| mitfaw2/w2; rag2fb101/fb101; mpv17a9/a9 | Complex | 5 figures from Tang et al., 2016 | |||
| mitfaw2/w2; rag2fb101/fb101; mpv17a9/a9; is5Tg | Complex | 3 figures from Tang et al., 2016 | 3 figures from Tang et al., 2016 |
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Supplemental Information
- Genotyping protocol
- None
- Amanda, S., Tan, T.K., Ong, J.Z.L., Theardy, M.S., Wong, R.W.J., Huang, X.Z., Ali, M.Z., Li, Y., Gong, Z., Inagaki, H., Foo, E.Y., Pang, B., Tan, S.Y., Iida, S., Sanda, T. (2022) IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma. Nature communications. 13:2420
- He, S., Zimmerman, M.W., Layden, H.M., Berezovskaya, A., Etchin, J., Martel, M.W., Thurston, G., Jing, C.B., van Rooijen, E., Kaufman, C.K., Rodig, S.J., Zon, L.I., Patton, E.E., Mansour, M.R., Look, A.T. (2021) Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 40(38):5718-5729
- Mansour, M.R., He, S., Li, Z., Lobbardi, R., Abraham, B.J., Hug, C., Rahman, S., Leon, T.E., Kuang, Y.Y., Zimmerman, M.W., Blonquist, T., Gjini, E., Gutierrez, A., Tang, Q., Garcia-Perez, L., Pike-Overzet, K., Anders, L., Berezovskaya, A., Zhou, Y., Zon, L.I., Neuberg, D., Fielding, A.K., Staal, F.J.T., Langenau, D.M., Sanda, T., Young, R.A., Look, A.T. (2018) JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. The Journal of experimental medicine. 215(7):1929-1945
- Athanasiadis, E.I., Botthof, J.G., Andres, H., Ferreira, L., Lio, P., Cvejic, A. (2017) Single-cell RNA-sequencing uncovers transcriptional states and fate decisions in haematopoiesis. Nature communications. 8:2045
- Benjamin, D.C., Hynes, R.O. (2017) Intravital imaging of metastasis in adult Zebrafish. BMC cancer. 17:660
- Tenente, I.M., Hayes, M.N., Ignatius, M.S., McCarthy, K., Yohe, M., Sindiri, S., Gryder, B., Oliveira, M.L., Ramakrishnan, A., Tang, Q., Chen, E.Y., Petur Nielsen, G., Khan, J., Langenau, D.M. (2017) Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma. eLIFE. 6
- Dee, C.T., Nagaraju, R.T., Athanasiadis, E.I., Gray, C., Fernandez Del Ama, L., Johnston, S.A., Secombes, C.J., Cvejic, A., Hurlstone, A.F. (2016) CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes. Journal of immunology (Baltimore, Md. : 1950). 197(9):3520-3530
- Moore, F.E., Garcia, E.G., Lobbardi, R., Jain, E., Tang, Q., Moore, J.C., Cortes, M., Molodtsov, A., Kasheta, M., Luo, C.C., Garcia, A.J., Mylvaganam, R., Yoder, J.A., Blackburn, J.S., Sadreyev, R.I., Ceol, C.J., North, T.E., Langenau, D.M. (2016) Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish. The Journal of experimental medicine. 213(6):979-92
- Moore, J.C., Tang, Q., Yordán, N.T., Moore, F.E., Garcia, E.G., Lobbardi, R., Ramakrishnan, A., Marvin, D.L., Anselmo, A., Sadreyev, R.I., Langenau, D.M. (2016) Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc-null SCID zebrafish. The Journal of experimental medicine. 213(12):2575-2589
- Tang, Q., Moore, J.C., Ignatius, M.S., Tenente, I.M., Hayes, M.N., Garcia, E.G., Torres Yordán, N., Bourque, C., He, S., Blackburn, J.S., Look, A.T., Houvras, Y., Langenau, D.M. (2016) Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish. Nature communications. 7:10358
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