Genomic Feature
um18
- ID
- ZDB-ALT-130718-3
- Name
- um18
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Lawson Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 1: 38879563 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
-
Mutation in vegfc exon4 is a Gln202 to Stop transition.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- in Exon 4 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Gln>Stop at position 202 (1)
- Flanking Sequence
-
TTCAAATAGCTTTTATCCATGAAAATTCCATTATATATTTTTTTCTTTGCATGTACATGGCAGGCTAGATTTTGTAACAGAGCTAAAATGTGCGCAAGTTCTTATATCTTCATTCAAGATGTCACATTATGTCATACCAGACATAACCAGCATAATGTTACAAAAACGTGGTAAATAGTGTCAAAATTGAATATACAATCATCATTATCATTGTCTTTGCAACAATAAGGTGTTCCATTCGTGACTTGAAATAGATTTGAAACTCTAGCTTTAATATGTTCAGTATACCCATACACAAGTAATTGCAGTGCAATCAAATATTTCACCTGGAATAGACATGTGTTTTAGAATATAATGACATTCTGTTGAAACCTTCTAAGCGTTCAAAGCAACAGAAAAATGAAAATACTGTAGATGTAAAAGAAAAACACTTGTGTGTTTGAACACTTACTCTGTTAGGGCCCTTCGTATGATTGAGTGCTGCTGTCGGTACAAATTTT
G/A TTTTGACAAACAGCTGCAGGAAGTGTGGTTGGCGAAGCTTATGGTGACCGGTTTGGTCCCTTGCTTGACTGGAACTGTGATTTCAAACAACTGCGGGATGAAAATAGAAGAAAGGTCATATTTTCAGTGAAATCAGACTAATGCAGACTATCTGACGTAAATGTGAAATCGTAGGAAAGGTTACTTAATCTTTAAGGAGTGTGCTGGATGTCAAAATGAAATGTGGTCTGTCAATTATATCTGAATCGAGATTAATGAAAAGATTTATGTTTAAATGAGTTGTGCAACTGCGAGATTACACAGAGTTTCTCTGAAATCTTTGAGTGTTCAAACAACCACAACTAGAGTATGATCAAACAGACTGGTAAGGGGAAATGGGTAATGGGGAACTTGTGCTAGATAATTTGCAAGGCAGGCAAATACTGTTACACCAATAAATCACAACTTCCTCCAGCTATAGGGAAACATTCCTAAGAATGTATGTTGAATGAGCAATTAGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| vegfcum18/um18 | Homozygous | ♀+/- ♂+/- | 2 figures  from Shin et al., 2016 | ||
| vegfcum18/+; nz101Tg | Complex | Figure 2 from Gancz et al., 2019 | |||
| vegfcum18/+; nz101Tg; wz2Tg | Complex | ||||
| vegfcum18/+; nz101Tg; y1Tg | Complex | 3 figures from Gancz et al., 2019 | |||
| vegfcum18/+; y1Tg | Complex | 2 figures from Shin et al., 2016 | |||
| vegfcum18/+; y1Tg | Complex | 4 figures from Villefranc et al., 2013 | Fig. 3 from Villefranc et al., 2013 | ||
| vegfcum18/um18; nz101Tg | Complex | Fig. 7 from Shin et al., 2016 | Fig. 7 from Shin et al., 2016 | ||
| vegfcum18/um18; y1Tg | Complex | 4 figures from 2 publications | Fig. 7 from Shin et al., 2016 | ||
| vegfcum18/um18; y1Tg/y1Tg | Complex | 5 figures from Villefranc et al., 2013 | 3 figures from Villefranc et al., 2013 | ||
| vegfcum18/+; y1Tg + MO2-dll4 | Complex | Fig. 3 from Villefranc et al., 2013 | Fig. 3 from Villefranc et al., 2013 |
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Supplemental Information
- Genotyping protocol
- None
- Parab, S., Card, O.A., Chen, Q., America, M., Buck, L.D., Quick, R.E., Horrigan, W.F., Levkowitz, G., Vanhollebeke, B., Matsuoka, R.L. (2023) Local angiogenic interplay of Vegfc/d and Vegfa controls brain region-specific emergence of fenestrated capillaries. eLIFE. 12:
- Jerafi-Vider, A., Bassi, I., Moshe, N., Tevet, Y., Hen, G., Splittstoesser, D., Shin, M., Lawson, N.D., Yaniv, K. (2021) VEGFC/FLT4-induced cell-cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cells. Cell Reports. 35:109255
- Parab, S., Quick, R.E., Matsuoka, R.L. (2021) Endothelial cell type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain. eLIFE. 10:
- Schiavo, R.K., Tamplin, O.J. (2021) Vascular endothelial growth factor-c regulates hematopoietic stem cell fate in the dorsal aorta. Development (Cambridge, England). 149(2):
- Gancz, D., Raftrey, B.C., Perlmoter, G., Marín-Juez, R., Semo, J., Matsuoka, R.L., Karra, R., Raviv, H., Moshe, N., Addadi, Y., Golani, O., Poss, K.D., Red-Horse, K., Stainier, D.Y., Yaniv, K. (2019) Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration. eLIFE. 8:
- Koenig, A.L., Baltrunaite, K., Bower, N.I., Rossi, A., Stainier, D.Y., Hogan, B.M., Sumanas, S. (2016) Vegfa signaling promotes zebrafish intestinal vasculature development through endothelial cell migration from the posterior cardinal vein. Developmental Biology. 411(1):115-27
- Shin, M., Male, I., Beane, T.J., Villefranc, J.A., Kok, F.O., Zhu, L.J., Lawson, N.D. (2016) Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors. Development (Cambridge, England). 143(20):3785-3795
- Hen, G., Nicenboim, J., Mayseless, O., Asaf, L., Shin, M., Busolin, G., Hofi, R., Almog, G., Tiso, N., Lawson, N.D., Yaniv, K. (2015) Venous-derived angioblasts generate organ-specific vessels during embryonic development. Development (Cambridge, England). 142(24):4266-78
- Villefranc, J.A., Nicoli, S., Bentley, K., Jeltsch, M., Zarkada, G., Moore, J.C., Gerhardt, H., Alitalo, K., and Lawson, N.D. (2013) A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development (Cambridge, England). 140(7):1497-1506
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