Genomic Feature
hu2098
- ID
- ZDB-ALT-070427-14
- Name
- hu2098
- Synonyms
-
- hcrtr 168 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation
- Protocol
- adult males treated with ENU
- Lab of Origin
- Hubrecht Institute
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 13: 2038212 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- A>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
TTCTAGTCTATTAGTTACTTATCTATACTATTAGTTATGTCTATTAGTTCATTATCTTGTCTATTAGTTCATTATCTAGTCCATTAGTTATTTATCTAGTCTATTAGTCCGTTATCTAGTCCATTAGTTGTTTTTCTAATCTATTAGTTAGTCTCTAGACTTCAGTCTCTAGTTTTTTTTTTATTTAAAACGACACATCTAAAACCCATCTGCAGAAAGAAGATGACTTCAGCACAGAGAAGCTTGAGTTGCAATTGAATCTGATTGTCTCTCTCTTTCTCTCTCACTGCTCACACAGCAGAAATAAATGGCCTGTCTAAAATGTTTAATGGCCTGTGTGGACAGGAGATGCTCACCTGGCCACTGCTCATCACAGACGGTGAACAGGCTGGTTTTGTTGGTGAGCTCCGGCATCAGGCTGCTGCTCTCCATCACCACGGCCTGGGGGATCATCATGATGCAGGACACCAGCCAGATCAGCACGATGCTCTTGCGGGCTC
T/A TTTAGCAGTGCTTTTGAATTTTAGCGGGTGGCAGATCGCATACCAGCGGTCCTGGGCAATGCAGCTCAGTGTCAGGACCGATACGGACACTGAGATGGTCTGCAGGATAACACACATGCAAAGATAGAGAGGACAATTAAAGAGTTATATGTGGAGAAATAACCAGTGTTGGGGAAAAATTATGTTAGAAAAAAATTCACAAAGCTAACTTCAACTTAAATATTTAAGTTTACTATTAATATTTAATTATTCAAATGTATAAATATTTCACAAGTGATGTTCAATAGACTAAGGACATGTTCACAGTATCTCCTTTAATATTTCTTTTTTCTTCTAAAATAAGGTAAATCGACATAAAAATCTTTGTGGCCTTGACTTGTTGTCATTATATTTTTTACGATTAGTTTGGCTGAAATAATATTTTTTAAAAGCCTCTATTATGGGTTTGTGAAAACCATCTTCTATGCAGTGTGCAACAAAGCTCTACGTGAATAAAATGT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| hcrtr2hu2098/hu2098 | Homozygous | ♀+/- ♂+/- | 5 figures  from 4 publications | Fig. 5 from Appelbaum et al., 2009 | |
| hcrtr2hu2098/+ | Heterozygous | ♀+/- ♂+/- | |||
| hcrtr2hu2098/+ (AB) | Heterozygous | Unknown | |||
| hcrtr2hu2098 | Unknown | Unknown | |||
| hcrtr2hu2098/hu2098; ct831Tg | Complex | Fig. 6 from Singh et al., 2015 |
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Supplemental Information
- Genotyping protocol
- None
- Ghosh, M., Rihel, J. (2020) Hierarchical Compression Reveals Sub-Second to Day-Long Structure in Larval Zebrafish Behavior. eNeuro. 7(4):
- Chen, A., Singh, C., Oikonomou, G., Prober, D.A. (2017) Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep. eNeuro. 4(1)
- Chen, S., Reichert, S., Singh, C., Oikonomou, G., Rihel, J., Prober, D.A. (2017) Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish. Neuron. 95(1):153-168.e6
- Singh, C., Rihel, J., Prober, D.A. (2017) Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling. Current biology : CB. 27(24):3796-3811.e5
- Zhao, Y., Singh, C., Prober, D., Wayne, N.L. (2016) Morphological and Physiological Interactions between GnRH3 and Hypocretin/Orexin Neuronal Systems in Zebrafish (Danio rerio). Endocrinology. 157(10):4012-4020
- Singh, C., Oikonomou, G., Prober, D.A. (2015) Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish. eLIFE. 4:e07000
- Appelbaum, L., Wang, G., Yokogawa, T., Skariah, G.M., Smith, S.J., Mourrain, P., and Mignot, E. (2010) Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons. Neuron. 68(1):89-98
- Appelbaum, L., Wang, G.X., Maro, G.S., Mori, R., Tovin, A., Marin, W., Yokogawa, T., Kawakami, K., Smith, S.J., Gothilf, Y., Mignot, E., and Mourrain, P. (2009) Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 106(51):21942-21947
- Yokogawa, T., Marin, W., Faraco, J., Pézeron, G., Appelbaum, L., Zhang, J., Rosa, F., Mourrain, P., and Mignot, E. (2007) Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants. PLoS Biology. 5(10):2379-2397
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