Genomic Feature
rw689
- ID
- ZDB-ALT-061025-2
- Name
- rw689
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Okamoto Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 35243487 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Polypeptide Truncation: Cys>Ser (1)
- Flanking Sequence
-
CAACCTGTATATCATGTTCATAGTACATCCATCTGTACATTTTTCCCATAGTTTTTCTATAATTGCACTTGCTGCTATTGCACTTCTGGTTAGACCTAAACTGCATTTCGTTGCCTTGTACTTGTACATGCGTAATGACACTAAAGTTGAATCTAATCACCTTCTAGTCACTAATGCCATTTGTATGCAAAAATAGTAAAGGTTATCTGTCAACCAAATCCTGGTTATTCAGCGGACTTCACATTAGAATCAGATCATCACTAAAACCCTATAGTTTTTCCTTTTACATTCTCAGAGAATTATATAGGACTGCATACATTTATATCTAGACACAACCCTTACAAGGACACCACATTATTAGAGCATGAAAATCAGCGCTAGTTCTAGGTTAAAGTAATGCAATGTGAATTGGTTTACCTCCATGGCGAGAGCAGCAGTCTGCTGATCATAGTGATTCAGAAGGTTGGGCATGAAGGTGGTATTGTAGGCAAGGCCCTGGC
A/T CATCCTCAATGTGATGGGCTCACAGCTAAACATGCTATGGCTTCCAGTAGCCTCCATATTGATGGCCATGCATACAGTCAGCATGGAGCACAGAGCCCAAAGCAGAACCATGGTGCGTCCGTCTGTGCTGTGACTTGCAAAGGACGGGTTGAATCAAGAAAATCTGAGCTCCTCCATTCCCTCATTAATTATCTGTTGCTTGACACAAGGATGAAATTGCACGGATAAAAGTGTGCTTCCCCATTTTGCTGAGCCAGATCCAGTGCTTTTCAATGCATGTCCATCCAGTGTTGCTATGTCTGCGTGCCAGGCATTTAGGAGATATGCATTTCCATCTGCGAGGGGAAGAGCATCAAATGTCATGTGCGAAATGAACAGACTAACATTAATTATTCATGAATGGGGCGACAGTTTATTTAAACATGAAAAACATCTAGAAGAGATCTCTCAAGGCATGGGAAATGTTTCCAGAGTGAACAATGATCAAAAAGCACTGACAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| fzd3arw689/rw689 | Homozygous | Unknown | Fig. 1  from Mathewson et al., 2019 | ||
| fzd3arw689/rw689 | Homozygous | ♀-/- ♂-/- | 4 figures from Wada et al., 2006 | Fig. S1 from Wada et al., 2006 | |
| fzd3arw689/rw689 | Homozygous | ♀+/- ♂+/- | 3 figures from Sun et al., 2016 | ||
| fzd3arw689/rw689 + MO1-dcc | Complex | Fig. 4 from Sun et al., 2016 |
1 - 4 of 4
Show
Supplemental Information
- Genotyping protocol
- None
- Meserve, J.H., Navarro, M.F., Ortiz, E.A., Granato, M. (2024) Celsr3 drives development and connectivity of the acoustic startle hindbrain circuit. PLoS Genetics. 20:e1011415e1011415
- Asante, E., Hummel, D., Gurung, S., Kassim, Y.M., Al-Shakarji, N., Palaniappan, K., Sittaramane, V., Chandrasekhar, A. (2021) Defective Neuronal Positioning Correlates With Aberrant Motor Circuit Function in Zebrafish. Frontiers in neural circuits. 15:690475
- Mathewson, A.W., Berman, D., Moens, C.B. (2019) Microtubules are required for the maintenance of planar cell polarity in monociliated floorplate cells. Developmental Biology. 452(1):21-33
- Davey, C.F., Mathewson, A.W., Moens, C.B. (2016) PCP Signaling between Migrating Neurons and their Planar-Polarized Neuroepithelial Environment Controls Filopodial Dynamics and Directional Migration. PLoS Genetics. 12:e1005934
- Sun, S.D., Purdy, A.M., Walsh, G.S. (2016) Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance. BMC Neuroscience. 17:83
- Wada, H., Tanaka, H., Nakayama, S., Iwasaki, M., and Okamoto, H. (2006) Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain. Development (Cambridge, England). 133(23):4749-4759
1 - 6 of 6
Show