Genomic Feature
dx2
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 1: 54018777 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A at position 1209 (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Cys>Tyr (1)
- Flanking Sequence
-
ACTATCTGTAAATTTACTAATACTATTTATAATAATAGTTCTCGAGATCTACCTAAGCTTAAACTCCCCTCTCGCCTTGCAAACGGGAGGGAGCCCCAGGCTCGAGGATCTTATGAGCTCAGGGCTCTCTTCCAGGACAGCATGCCAAACAAGCTTTATAATCAATCATCAGCTAAGTGTGAACTCTTGAAACACATAGATCACAACAAACACAAGTGAAACACTTACACACAGCGGTCCACTTCTTTTGTTTTAATGCTTCTCCTGTTTGTCGTCATTTACAGCTATCTGCCTGCCAGGGTGCGACGAGGAGCATGGATTCTGTGAGAAACCTGGCGAGTGCAAGTAGGTTGATCACAATTGTTAAGCTGTTGAAGTCATGTTCAGGATTGATTTACTTATGAGGTGATTTGTTTACCTGTGCATCAGGTGCAGAGTGGGCTTTAAAGGGCGCTACTGTGATGAGTGTATACGCTACCCAGGATGCCTTCACGGTACCT
G/A CCAACAGCCATGGCAATGCAACTGCCAGGAAGGCTGGGGTGGGCTCTTCTGCAACCAAGGTAAGAAAGTGATCAGAAACACAGGGAAGATTAAGGGAAAGCTGTTTAAAGGGATAGTTCACCCCAGTTTATTCACAATTTACTCTCACTAAAGTTGTTCCAAACCTTTATTCTGTCCAAAACAAGAGAAGATCTTCTTAAGAAAGCTTAAAACTTGTAATTACTGACTCCCATAGTAGGAAAAACTAATAATATGGATGTCATTGGTTACAGGTTTTCAACATTTTTCTAAATATCTTCTCTTGAATTCAACAGAAGAAAGAATCAATCAGGTTTGTGTGACTAAATGATGACTAAGTTATGGGTGAACTGTCCCTTTAAATGGTTGTTTTTCCTACTGTGGAAGTCAATGGGTACCAGGAGACAGGCTTAAAACCACATGATAGGACAGTAAACGACAAGCTCATTTTCATTTTTGGGTGAACTATCCCTTTAAAAGCC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| dladx2/dx2 | Homozygous | Unknown | 2 figures  from 2 publications | 2 figures from Riley et al., 2004 | |
| dladx2/dx2 | Homozygous | ♀+/- ♂+/- | 7 figures from Riley et al., 1999 | 3 figures from Riley et al., 1999 | |
| dladx2/+ | Heterozygous | Unknown | text only from Riley et al., 1999 | ||
| dladx2/dx2; mib1ta52b/ta52b | Complex | text only from Riley et al., 1999 | |||
| dladx2/dx2; pax2atb21/tb21 | Complex | 3 figures from Riley et al., 1999 | Fig. 7 from Riley et al., 1999 | ||
| dladx2/+; Df(Chr01:cx41.8,dla,msxb,otx1l)b220/+ | Complex | 2 figures from Riley et al., 1999 |
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Supplemental Information
- Genotyping protocol
- None
- Park, H.C., Boyce, J., Shin, J., and Appel, B. (2005) Oligodendrocyte specification in zebrafish requires notch-regulated cyclin-dependent kinase inhibitor function. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(29):6836-6844
- Riley, B.B., Chiang, M.Y., Storch, E.M., Heck, R., Buckles, G.R., and Lekven, A.C. (2004) Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain. Developmental Dynamics : an official publication of the American Association of Anatomists. 231(2):278-291
- Park, H.-C. and Appel, B. (2003) Delta-Notch signaling regulates oligodendrocyte specification. Development (Cambridge, England). 130(16):3747-3755
- Cornell, R.A. and Eisen, J.S. (2000) Delta signaling mediates segregation of neural crest and spinal sensory neurons from zebrafish lateral neural plate. Development (Cambridge, England). 127(13):2873-2882
- Appel, B., Fritz, A., Westerfield, M., Grunwald, D.J., Eisen, J.S., and Riley, B.B. (1999) Delta-mediated specification of midline cell fates in zebrafish embryos. Current biology : CB. 9:247-256
- Riley, B.B., Chiang, M.Y., Farmer, L., and Heck, R. (1999) The deltaA gene of zebrafish mediates lateral inhibition of hair cells in the inner ear and is regulated by pax2.1. Development (Cambridge, England). 126(24):5669-5678
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