Lab

Riley Lab

Lab ID
ZDB-LAB-970908-94
PI / Directory
Riley, Bruce
Contact Person
Riley, Bruce
Email
briley@mail.bio.tamu.edu
URL
Address
Department of Biology Texas A&M University 118A Biological Sciences Building 3258 TAMUS College Station, TX 77843-3258 USA
Country
United States
Phone
(979) 845-6494
Fax
(979) 845-2891
Line Designation
x
Genomic Features
Statement of Research Interest
For most studies we use a phenotype-to-gene strategy: Randomly induced mutations are propagated to determine whether carriers display developmental defects. Mutations of interest are then genetically mapped, and eventually cloned, using PCR-based technology. We are also using gene-to-phenotype ("reverse genetics") strategies to functionally disrupt previously cloned genes. With either strategy, an important goal is to phenotypically analyze mutant embryos to establish the cellular and molecular bases for their developmental defects. Currently, the lab is focused on analysis of mutations that perturb hindbrain and inner ear development. Both organ systems are highly conserved among vertebrates and are essential for normal embryonic development and survival. Specific molecules and pathways of interest include Delta-Notch, FGF, and Wnt signaling, as well as members of the muscle segment homeobox (msx) and paired box (pax) families of transcription factors.
Lab Members
Kwon, Hye-Joo Post-Doc Butler, Bonny Graduate Student Kwak, Su-Jin Graduate Student
Padanad, Mahesh Graduate Student Sweet, Elly Graduate Student Vemaraju, Shruti Graduate Student
Dhason, Reeha Technical Staff
Zebrafish Publications of lab members