Genomic Feature
m93
- ID
- ZDB-ALT-010411-18
- Name
- m93
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Stainier Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 3: 54617468 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Arg>His at position 150 (1)
- Flanking Sequence
-
TCCTCATGTCCTTACTCCGCAAGGTGTAGATCAACGGGTTCAGTGCCGAATTCAGTGTGGCAAAGCTGAAGAAGATGCCAGCGTTATTGAGGATAGGGCATTGCTTCATCTTGCAGGAAGTGTCCAGGAGGAGGATGGTGAAGGCAGGCAGCCAACAGATGATGAAGACGCCAAGGACAATTGTGACCGTCTTCAGGAGAGCATACGCTGGAGAATTGGTGGCCTCTTGGTGGCTGGTGCGCACAATGAGATAGATGCGAACGTAAAGGATCACGATGGACAGCAAGATGATGCTAAAGATGGTGACAACAAACCGGATGTAGTATCGGGTGTTGAGGGGCAAAACAGCTGAGCAATCATCCAGGTTATTAATACAGTTCCAACCTATAATAGGAAGACCTCCTAGAAGAATGGACATCACCCAGCATGCTCCGATCAGAAGAAACATGCGGCACGTTTTGTTGGATCCGTAAACCTTGACCTTGGTGATGGCGATGTAG
C/T GCTCGATAGCAATAGCCAGCAGGCTGAAAACGGAGGCGGACAAAGCAATGAAAGCAGTCCCCTCTCGTATGAACCACTGGACAGGAGTCAAATGAAATGTCCTAGGGCCAGACAGGAAGATGTTGGCAATGTATGCAGAGCCAGCTAGTAGGTCCGAGAAGGCCAGGTTCCCAATGAAGAAGAACATGGCTGAGTGGAACTTTTTATTCCTAAACACAGCGATGAGCACTAGGAGGTTTTCCAAGATGATGATGCTGCAGATTACGACAAATAAAATGTTCAGGGAGCTCAAGCTTTGTTTGCTCTCGATGCGGTCTCTTAGTTCCTCTGCGGTCATCTCCTTAGCAGTGAGATAGTGGACCTGGATGAGGGTCTTGTTGAAGTACTGGGAGTATTTGCTCATGGTGACAGCTTGGCAAAACCCCGCAAACAGACGGCAAGTAGTCATTCAGAGGGCAGCTTTTTTTTGAGCTTGTCTGGGCCAGGCACAGGAAATGAGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| s1pr2m93/m93 | Homozygous | ♀+/- ♂+/- | 14 figures  from 11 publications | 7 figures from 5 publications | |
| s1pr2m93/+ | Heterozygous | Unknown | |||
| s1pr2m93/+ (AB) | Heterozygous | Unknown | |||
| s1pr2m93/+ (AB/TL) | Heterozygous | Unknown | |||
| s1pr2m93/m93; ha01Tg | Complex | 2 figures from Ye et al., 2013 | 2 figures from Ye et al., 2013 | ||
| s1pr2m93/m93 + MO1-grk3 | Complex | Fig. 7 from Burczyk et al., 2015 | Fig. 7 from Burczyk et al., 2015 |
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Supplemental Information
- Genotyping protocol
- m93.pdf
- Xie, H., Ye, D., Sepich, D., Lin, F. (2016) S1pr2/Gα13 signaling regulates the migration of endocardial precursors by controlling endoderm convergence. Developmental Biology. 414:228-43
- Burczyk, M.S., Burkhalter, M.D., Blätte, T., Matysik, S., Caron, M.G., Barak, L.S., Philipp, M. (2015) Phenotypic Regulation of the Sphingosine 1-Phosphate Receptor Miles Apart by G Protein-Coupled Receptor Kinase 2. Biochemistry. 54(3):765-75
- Gu, Y., Shea, J., Slattum, G., Firpo, M.A., Alexander, M., Mulvihill, S.J., Golubovskaya, V.M., Rosenblatt, J. (2015) Defective apical extrusion signaling contributes to aggressive tumor hallmarks. eLIFE. 4:e04069
- Hisano, Y., Inoue, A., Taimatsu, K., Ota, S., Ohga, R., Kotani, H., Muraki, M., Aoki, J., Kawahara, A. (2015) Comprehensive analysis of sphingosine-1-phosphate receptor mutants during zebrafish embryogenesis. Genes to cells : devoted to molecular & cellular mechanisms. 20(8):647-58
- Mendelson, K., Lan, Y., Hla, T., Evans, T. (2015) Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(8):948-54
- Ye, D., Xie, H., Hu, B., Lin, F. (2015) Endoderm convergence controls subduction of the myocardial precursors during heart-tube formation. Development (Cambridge, England). 142:2928-40
- Fukui, H., Terai, K., Nakajima, H., Chiba, A., Fukuhara, S., Mochizuki, N. (2014) S1P-Yap1 Signaling Regulates Endoderm Formation Required for Cardiac Precursor Cell Migration in Zebrafish. Developmental Cell. 31:128-136
- Lin, C.Y., Huang, C.C., Wang, W.D., Hsiao, C.D., Cheng, C.F., Wu, Y.T., Lu, Y.F., and Hwang, S.P. (2013) Low temperature mitigates cardia bifida in zebrafish embryos. PLoS One. 8(7):e69788
- Ye, D., and Lin, F. (2013) S1pr2/Gα13 signaling controls myocardial migration by regulating endoderm convergence. Development (Cambridge, England). 140(4):789-799
- Balczerski, B., Matsutani, M., Castillo, P., Osborne, N., Stainier, D.Y., and Crump, J.G. (2012) Analysis of Sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors. Developmental Biology. 361(2):230-241
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