ZFIN View Person: Westerfield, Monte

ZFIN ID: ZDB-PERS-960805-676

Westerfield, Monte
Zebrafish International Resource Center (ZIRC)
and also: ZFIN Database Team
Westerfield Lab
5274 University of Oregon
Eugene, OR
97403-5274
USA

Phone: (541) 346-4607	Email: monte@uoneuro.uoregon.edu
FAX: (541) 346-4548	URL: http://www.neuro.uoregon.edu/westerf/lab.html

Biography and Research Interests:

A.B., Princeton University
Ph.D., Duke University

Research Interests:

Our laboratory focuses on understanding the mechanisms that regulate the differentiation of neurons. We study how the specific properties of different kinds of neurons are regulated.

We use zebrafish and a combination of anatomical, physiological, molecular, and genetic techniques. The goal of our research is to provide a better understanding of the mechanisms that regulate the establishment of specific neuronal cell fates during normal development and what goes wrong during disease.

Current projects include understanding the molecular genetics of ear, eye and muscle development, particularly as models of human disease.

Publications:

Dahdul, W.M., Balhoff, J.P., Engeman, J., Grande, T., Hilton, E.J., Kothari, C., Lapp, H., Lundberg, J.G., Midford, P.E., Vision, T.J., Westerfield, M., and Mabee, P.M. (2010) Evolutionary characters, phenotypes and ontologies: curating data from the systematic biology literature. PLoS One. 5(5):e10708

Dahdul, W.M., Lundberg, J.G., Midford, P.E., Balhoff, J.P., Lapp, H., Vision, T.J., Haendel, M.A., Westerfield, M., and Mabee, P.M. (2010) The teleost anatomy ontology: anatomical representation for the genomics age. Syst. Biol.. 59(4):369-383

Delaurier, A., Eames, B.F., Blanco-S�nchez, B., Peng, G., He, X., Swartz, M.E., Ullmann, B., Westerfield, M., and Kimmel, C.B. (2010) Zebrafish sp7:EGFP: A transgenic for studying otic vesicle formation, skeletogenesis, and bone regeneration. Genesis. 48(8):505-511

Ebermann, I., Phillips, J.B., Liebau, M.C., Koenekoop, R.K., Schermer, B., Lopez, I., Sch�fer, E., Roux, A.F., Dafinger, C., Bernd, A., Zrenner, E., Claustres, M., Blanco, B., N�rnberg, G., N�rnberg, P., Ruland, R., Westerfield, M., Benzing, T., and Bolz, H.J. (2010) PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome. J. Clin. Invest.. 120(6):1812-1823

Carmichael, C., Westerfield, M., and Varga, Z.M. (2009) Cryopreservation and in vitro fertilization at the zebrafish international resource center. Methods Mol. Biol.. 546:45-65

Ochi, H., and Westerfield, M. (2009) Lbx2 regulates formation of myofibrils. BMC Dev. Biol.. 9:13

Ramsay, J.M., Feist, G.W., Varga, Z.M., Westerfield, M., Kent, M.L., and Schreck, C.B. (2009) Whole-body cortisol response of zebrafish to acute net handling stress. Aquaculture. 297(1-4):157-162

Toro, S., Wegner, J., Muller, M., Westerfield, M., and Varga, Z.M. (2009) Identification of differentially expressed genes in the zebrafish hypothalamic-pituitary axis. Gene Expr. Patterns. 9(4):200-208

Viktorin, G., Chiuchitu, C., Rissler, M., Varga, Z.M., and Westerfield, M. (2009) Emx3 is required for the differentiation of dorsal telencephalic neurons. Dev. Dyn.. 238(8):1984-1998

Washington, N.L., Haendel, M.A., Mungall, C.J., Ashburner, M., Westerfield, M., and Lewis, S.E. (2009) Linking Human Diseases to Animal Models Using Ontology-Based Phenotype Annotation. PLoS Biol.. 7(11):e1000247

Dutta, S., Dietrich, J.E., Westerfield, M., and Varga, Z.M. (2008) Notch signaling regulates endocrine cell specification in the zebrafish anterior pituitary. Dev. Biol.. 319(2):248-257

Ochi, H., Hans, S., and Westerfield, M. (2008) Smarcd3 regulates the timing of zebrafish myogenesis onset. J. Biol. Chem.. 283(6):3529-3536

Rotllant, J., Liu, D., Yan, Y.L., Postlethwait, J.H., Westerfield, M., and Du, S.J. (2008) Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear. Matrix Biol.. 27(6):561-572

Sprague, J., Bayraktaroglu, L., Bradford, Y., Conlin, T., Dunn, N., Fashena, D., Frazer, K., Haendel, M., Howe, D.G., Knight, J., Mani, P., Moxon, S.A., Pich, C., Ramachandran, S., Schaper, K., Segerdell, E., Shao, X., Singer, A., Song, P., Sprunger, B., Van Slyke, C.E., and Westerfield, M. (2008) The Zebrafish Information Network: the zebrafish model organism database provides expanded support for genotypes and phenotypes. Nucleic Acids Res.. 36:D768-772

Chen, Y.H., Wang, Y.H., Chang, M.Y., Lin, C.Y., Weng, C.W., Westerfield, M., and Tsai, H.J. (2007) Multiple upstream modules regulate zebrafish myf5 expression. BMC Dev. Biol.. 7(1):1

Hans, S., and Westerfield, M. (2007) Changes in retinoic acid signaling alter otic patterning. Development. 134(13):2449-2458

Hans, S., Christison, J., Liu, D., and Westerfield, M. (2007) Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. BMC Dev. Biol.. 7(1):5

Mabee, P.M., Arratia, G., Coburn, M., Haendel, M., Hilton, E.J., Lundberg, J.G., Mayden, R.L., Rios, N., and Westerfield, M. (2007) Connecting evolutionary morphology to genomics using ontologies: a case study from Cypriniformes including zebrafish. J. Exp. Zoolog. B Mol. Dev. Evol.. 308(5):655-668

Mabee, P.M., Ashburner, M., Cronk, Q., Gkoutos, G.V., Haendel, M., Segerdell, E., Mungall, C., and Westerfield, M. (2007) Phenotype ontologies: the bridge between genomics and evolution. Trends Ecol. Evol.. 22(7):345-350

Nixon, S.J., Carter, A., Wegner, J., Ferguson, C., Floetenmeyer, M., Riches, J., Key, B., Westerfield, M., and Parton, R.G. (2007) Caveolin-1 is required for lateral line neuromast and notochord development. J. Cell Sci.. 120(13):2151-2161

Ochi, H., and Westerfield, M. (2007) Signaling networks that regulate muscle development: lessons from zebrafish. Dev. Growth Differ.. 49(1):1-11

Schlueter, P.J., Peng, G., Westerfield, M., and Duan, C. (2007) Insulin-like growth factor signaling regulates zebrafish embryonic growth and development by promoting cell survival and cell cycle progression. Cell Death Differ.. 14(6):1095-1105

Ochi, H., Pearson, B.J., Chuang, P.T., Hammerschmidt, M., and Westerfield, M. (2006) Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened. Dev. Biol.. 297(1):127-140

Peng, G., and Westerfield, M. (2006) Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists. Development. 133(16):3191-3200

Ramsay, J.M., Feist, G.W., Varga, Z.M., Westerfield, M., Kent, M.L., and Schreck, C.B. (2006) Whole-body cortisol is an indicator of crowding stress in adult zebrafish, Danio rerio. Aquaculture. 258(1-4):565-574

Sprague, J., Bayraktaroglu, L., Clements, D., Conlin, T., Fashena, D., Frazer, K., Haendel, M., Howe, D.G., Mani, P., Ramachandran, S., Schaper, K., Segerdell, E., Song, P., Sprunger, B., Taylor, S., Van Slyke, C.E., and Westerfield, M. (2006) The Zebrafish Information Network: the zebrafish model organism database. Nucleic Acids Res.. 34:D581-585

Dutta, S., Dietrich, J.E., Aspock, G., Burdine, R.D., Schier, A., Westerfield, M., and Varga, Z.M. (2005) pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development. 132(7):1579-1590

Nixon, S.J., Wegner, J., Ferguson, C., M�ry, P.F., Hancock, J.F., Currie, P.D., Key, B., Westerfield, M., and Parton, R.G. (2005) Zebrafish as a model for caveolin-associated muscle disease; caveolin-3 is required for myofibril organization and muscle cell patterning. Hum. Mol. Genet.. 14(13):1727-1743

Wang-Buhler, J.L., Lee, S.J., Chung, W.G., Stevens, J.F., Tseng, H.P., Hseu, T.H., Hu, C.H., Westerfield, M., Yang, Y.H., Miranda, C.L., and Buhler, D.R. (2005) CYP2K6 from zebrafish (Danio rerio): Cloning, mapping, developmental/tissue expression, and aflatoxin B1 activation by baculovirus expressed enzyme. Comp. Biochem. Physiol. C Toxicol. Pharmacol.. 140(2):207-219

Yan, Y.L., Willoughby, J., Liu, D., Crump, J.G., Wilson, C., Miller, C.T., Singer, A., Kimmel, C., Westerfield, M., and Postlethwait, J.H. (2005) A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. Development. 132(5):1069-1083

Hans, S., Liu, D., and Westerfield, M. (2004) Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors. Development. 131(20):5091-5102

Henrich, T., Ramialison, M., Segerdell, E., Westerfield, M., Furutani-Seiki, M., Wittbrodt, J., Kondoh, H. (2004) GSD: a genetic screen database. Mech. Dev.. 121(7-8):959-963

Hirsinger, E., Stellabotte, F., Devoto, S.H., and Westerfield, M. (2004) Hedgehog signaling is required for commitment but not initial induction of slow muscle precursors. Dev. Biol.. 275(1):143-157

Jensen, A.M., and Westerfield, M. (2004) Zebrafish Mosaic Eyes Is a Novel FERM Protein Required for Retinal Lamination and Retinal Pigmented Epithelial Tight Junction Formation. Curr. Biol.. 14(8):711-717

Wiellette, E., Grinblat, Y., Austen, M., Hirsinger, E., Amsterdam, A., Walker, C., Westerfield, M., and Sive, H. (2004) Combined haploid and insertional mutation screen in the zebrafish. Genesis. 40(4):231-240

Liu, D., Chu, H., Maves, L., Yan, Y.-L., Morcos, P.A., Postlethwait, J.H., and Westerfield, M. (2003) Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification. Development. 130(10):2213-2224

Sprague, J., Clements, D., Conlin, T., Edwards, P., Frazer, K., Schaper, K., Segerdell, E., Song, P., Sprunger, B., and Westerfield, M. (2003) The Zebrafish Information Network (ZFIN): the zebrafish model organism database. Nucleic Acids Res.. 31(1):241-243

Yan, Y.-L., Miller, C.T., Nissen, R.M., Singer, A., Liu, D., Kirn, A., Draper, B., Willoughby, J., Morcos, P.A., Amsterdam, A., Chung, B.-C., Westerfield, M., Haffter, P., Hopkins, N., Kimmel, C., and Postlethwait, J.H. (2002) A zebrafish sox9 gene required for cartilage morphogenesis. Development. 129(21):5065-5079

Hawkins, W.E., Clark, M.S., Shima, A., Walter, R.B., Winn, R.N., and Westerfield, M. (2001) Four resource centers for fishes: specifies, stocks, and services. Mar. Biotechnol.. 3:S239-S248

Hirsinger, E. and Westerfield, M. (2001) Segregation of zebrafish muscle lineages: lineage relationships and cellular commitment. Dev. Biol.. 235(1):180 (#40)

Jensen, A.M. and Westerfield, M. (2001) Zebrafish mosaic eyes gene is required for tight junction formation in the retinal pigmented epithelium. Dev. Biol.. 235(1):181 (#46)

Jensen, A.M., Walker, C., and Westerfield, M. (2001) mosaic eyes: a zebrafish gene required in pigmented epithelium for apical localization of retinal cell division and lamination. Development. 128(1):95-105

Sprague, J., Doerry, E., Douglas, S., Westerfield, M., and ZFIN GRP, (Conlin, T., Clements, D., Edwards, P., Frazer, K., Schaper, K., Segerdell, E.) (2001) The Zebrafish Information Network (ZFIN): a resource for genetic, genomic and developmental research. Nucleic Acids Res.. 29(1):87-90

Varga, Z.M., Amores, A., Lewis, K.E., Yan, Y.-L., Postlethwait, J.H., Eisen, J.S., and Westerfield, M. (2001) Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development. 128(18):3497-3509

Whitlock, K.E. and Westerfield, M. (2000) The olfactory placodes of the zebrafish form by convergence of cellular fields at the edge of the neural plate. Development. 127(17):3645-3653

Appel, B., Fritz, A., Westerfield, M., Grunwald, D.J., Eisen, J.S., and Riley, B.B. (1999) Delta-mediated specification of midline cell fates in zebrafish embryos. Curr. Biol.. 9:247-256

Detrich, H.W. III, Westerfield, M., and Zon, L.I. (1999) Overview of the zebrafish system. In The Zebrafish: Biology. H.W. Detrich, L.I. Zon, and M. Westerfield, eds. Methods Cell Biol.. 59:3-10

Detrich, H.W. III, Westerfield, M., and Zon, L.I., eds. (1999) The Zebrafish: Genetics and Genomics. San Diego: Academic Press. 60:407

Detrich, H.W. III, Westerfield, M., and Zon, L.I., eds. (1999) The Zebrafish: Biology. San Diego: Academic Press, Methods Cell Biol.. 59:391

Fashena, D. and Westerfield, M. (1999) Secondary motoneuron axons localize DM-GRASP on their fasciculated segments. J. Comp. Neurol.. 406(3):415-424

Varga, Z.M., Wegner, J., and Westerfield, M. (1999) Anterior movement of ventral diencephalic precursors separates the primordial eye field in the neural plate and requires cyclops. Development. 126:5533-5546

Westerfield, M., Doerry, E., and Douglas, S. (1999) Zebrafish in the net. Trends Genet.. 15(6):248-249

Westerfield, M., Doerry, E., Kirkpatrick, A.E., and Douglas, S.A. (1999) Zebrafish informatics and the ZFIN database. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:339-355

Amores, A., Force, A., Yan, Y.-L. Joly, L., Amemiya, C., Fritz, A., Ho, R., Langeland, J., Prince, V., Wang, Y.-L., Westerfield, M., Ekker, M., and Postlethwait, J.H. (1998) Zebrafish hox clusters and vertebrate genome evolution. Science.. 282:1711-1714

Doerry, E., Douglas, S.A., Kirkpatrick, A.E., and Westerfield, M. (1998) The zebrafish information network project. Interactions. 3:69

Houart, C., M. Westerfield, and S.W. Wilson (1998) A small population of anterior cells patterns the forebrain during gastrulation. Nature. 391:788-792

Postlethwait, J.H, Yan, Y.-L., Gates, M.A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E.S., Force, A., Gong, Z., Goutel, C., Fritz, A., Kelsh, R., Knapik, E., Liao, E., Paw, B., Ransom, D., Singer, A., Thomson, M., Abduljabbar, T.S., Yelick, P., Beier, D., Joly, J.-S., Larhammar, D., Rosa, F., Westerfield, M., Zon, L.I., Johnson, S.L., and Talbot, W.S. (1998) Vertebrate genome evolution and the zebrafish gene map. Nature Genet.. 18:345-349

Sepich, D.S., Wegner, J., O'Shea, S., and Westerfield, M. (1998) An altered intron inhibits synthesis of the acetylcholine receptor alpha-subunit in the paralyzed zebrafish mutant nic1. Genetics. 184:361-372

Whitlock, K.E. and Westerfield, M. (1998) A transient population of neurons pioneers the olfactory pathway in the zebrafish. J. Neurosci.. 18:8919-8927

Doerry, E., Douglas, S., Kirkpatrick, T., and Westerfield, M. (1997) Moving beyond html to create a multimedia database with user-centered design: a case study of a biological database. Tech. Report CIS-TR-97-02, Computer and Information Science Department, University of Oregon.

Doerry, E., Douglas, S.A., Kirkpatrick, A.E., and Westerfield, M. (1997) Participatory design for widely-distributed scientific communities. Proc. 3rd Conf. Human Factors and the Web.

Doerry, E., Kirkpatrick, A.E., Douglas, S.A., and Westerfield, M. (1997) Task-centered Navigation in a Web-accessible Data Space. AACE/WebNet97 conference on WWW, Internet, and Intranet, Toronto, Canada, Nov. 1,1997.

Du, S.J., S.H. Devoto, M. Westerfield, and R.T. Moon (1997) Positive and negative regulation of muscle cell identity by members of the hedgehog and TGF-b gene families. J. Cell Biol.. 139:145-156

Ekker, M., Akimenko, M.-A., Allende, M.L., Smith, R., Drouin, G., Langille, R.M., Weinberg, E.S., and Westerfield, M. (1997) Relationships among msx gene structure and function in zebrafish and other vertebrates. Mol. Biol. Evol.. 14:1008-1022

Fishman, M., D.Y. Stainier, R. Breitbart, and M. Westerfield (1997) Zebrafish: Genetic and embryological methods in a transparent vertebrate embryo. Methods Cell Biol.. 52:67-82

Melan�on, E., Liu, D.W.C., Westerfield, M., and Eisen, J.S. (1997) Pathfinding by identified zebrafish motoneurons in the absence of muscle pioneers. J. Neurosci.. 17(20):7796-7804

Westerfield, M., E. Doerry, A.E. Kirkpatrick, W. Driever, and S.A. Douglas (1997) An on-line database for zebrafish development and genetics research. Sem. Cell Dev. Biol.. 8:477-488

Devoto, S.H., Melancon, E., Amacher, S.L., Eisen, J.S., and Westerfield, M. (1996) Influence of axial mesoderm on the development of slow muscle precursors. Dev. Biol.. 175(2):386

Devoto, S.H., Melancon, E., Eisen, J.S., and Westerfield, M. (1996) Identification of separate slow and fast muscle precursor cells in vivo, prior to somite formation. Development. 122(11):3371-3380

Fritz, A., Rozowski, M., Walker, C., and Westerfield, M. (1996) Identification of selected gamma-ray induced deficiencies in zebrafish using multiplex polymerase chain reaction. Genetics. 144(4):1735-1745

Akimenko, M.A., Johnson, S.L., Westerfield, M., and Ekker, M. (1995) Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish. Development. 121:347-357

Westerfield, M. (1995) The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio), 3rd Edition. Eugene, OR, University of Oregon Press,. 385

Akimenko, M.A., Ekker, M., Wegner, J., Lin, W., and Westerfield, M. (1994) Combinatorial expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head. J. Neurosci.. 14:3475-3486

Reinhard, E., Nedivi, E., Wegner, J., Skene, J.H.P., and Westerfield, M. (1994) Neural selective activation and temporal regulation of a mammalian GAP-43 promoter in zebrafish. Development. 120:1767-1775

Sepich, D.S., Ho, R.K., and Westerfield, M. (1994) Autonomous expression of the nic1 acetylcholine receptor mutation in zebrafish muscle cells. Dev. Biol.. 161:84-90

Westerfield, M. (1993) The Zebrafish Book; A Guide for the Laboratory Use of Zebrafish (Brachydanio rerio). University of Oregon Press, Eugene,2nd edition. 300P

Westerfield, M. and Liu, D.W. (1993) Cellular interactions regulating the formation of terminal arbors by primary motoneurons in the zebrafish. In Cell-Cell Signaling in Vertebrate Development, E. Robertson, F.R. Maxfield, and H.J. Vogel, eds., Academic Press. 113-122

Westerfield, M., Akimenko, M.A., Ekker, M., and P�schel, A. (1993) Eyes, ears and homeobox genes in zebrafish embryos. In Molecular Basis of Morphogenesis, M. Bernfield, ed., New York, NY: John Wiley & Sons, Wiley-Liss Division. 67-75

Westerfield, M., Stuart, G., and Wegner, J. (1993) Expression of foreign genes in zebrafish embryos. In Devel. Ind. Microbiol., Vol II, William C. Brown, ed., New York. 658-665

Ekker, M., Akimenko, M.A., BreMiller, R., and Westerfield, M. (1992) Regional expression of three homeobox transcripts in the inner ear of zebrafish embryos. Neuron. 9:27-35

Ekker, M., Fritz, A., and Westerfield, M. (1992) Identification of two families of satellite-like repetitive DNA sequences from the zebrafish (Brachydanio rerio). Genomics. 13:1169-1173

Ekker, M., Wegner, J., Akimenko, M.A., and Westerfield, M. (1992) Coordinate embryonic expression of three zebrafish engrailed genes. Development. 116:1001-1010

Goff, D.J., Galvin, K., Katz, H., Westerfield, M., Lander, E.S., and Tabin, C.J. (1992) Identification of polymorphic simple sequence repeats in the genome of the zebrafish. Genomics. 14:200-202

Liu, D.W. and Westerfield, M. (1992) Clustering of muscle acetylcholine receptors requires motoneurons in live embryos but not in cell culture. J. Neurosci.. 12:1859-1866

P�schel, A.W., Gruss, P., and Westerfield, M. (1992) Sequence and expression pattern of pax-6 are highly conserved between zebrafish and mice. Development. 114:643-651

P�schel, A.W., Westerfield, M., and Dressler, G.R. (1992) Comparative analysis of Pax-2 protein distributions during neurulation in mice and zebrafish. Mech. Dev.. 38:197-208

Westerfield, M. (1992) Zebrafish Hox and Pax genes. Neurosci. Facts. 3:3

Westerfield, M. (1992) Motor axon pathfinding. Curr. Opin. Neurobiol.. 2:28-30

Westerfield, M., Wegner, J., Jegalian, B.G., De Robertis, E.M., and P�schel, A.W. (1992) Specific activation of mammalian Hox promoters in mosaic transgenic zebrafish. Genes Dev.. 6:591-598

Ekker, M., Akimenko, M.A., BreMiller, R., and Westerfield, M. (1991) Characterization of four homeobox genes expressed in zebrafish neural crest. Soc. Neurosci. Abstr.. 17:924

Hatta, K., BreMiller, R.A., Westerfield, M., and Kimmel, C.B. (1991) Diversity of expression of engrailed-like antigens in zebrafish. Development. 112:821-832

Westerfield, M., Wegner, J., Akimenko, M., Ekker, M., Eisen, J., and Halpern, M. (1991) A role for engrailed gene in zebrafish muscle patterning. Soc. Neurosci. Abstr.. 17:761

Akimenko, M.A., Ekker, M., and Westerfield, M. (1990) Characterization of three zebrafish genes related to Hox-7. In Developmental Patterning of the Vertebrate Limb, J.R. Hinchliffe, J. Hurle and D. Summerbell, eds., New York: Plenum Press. 61-63

Felsenfeld, A.L., Walker, C., Westerfield, M., Kimmel, C., and Streisinger, G. (1990) Mutations affecting skeletal muscle myofibril structure in the zebrafish. Development. 108:443-459

Kimmel, C.B. and Westerfield, M. (1990) Primary neurons of the zebrafish. In Signal and Sense, G.M. Edelman, W.E. Gall, and M.W. Cowan, eds., New York: Wiley-Liss. 561-588

Liu, D.W.C. and Westerfield, M. (1990) The formation of terminal fields in the absence of competitive interactions among primary motoneurons in the zebrafish. J. Neurosci.. 10:3947-3959

Metcalfe, W.K. and Westerfield, M. (1990) Primary motoneurons of the zebrafish. In Systems Approaches to Developmental Neurobiology, P.A. Raymond, S.S. Easter and G.M. Innocenti, eds., NATO ASI Series A,New York: Plenum Press. 192:41-47

Stuart, G.W., Vielkind, J.R., McMurray, J.V., and Westerfield, M. (1990) Stable lines of transgenic zebrafish exhibit reproducible patterns of transgene expression. Development. 109:577-584

Westerfield, M. (1990) Does the mesoderm induce Hox gene expression in the zebrafish nervous system?. Soc. Neurosci. Abstr.. 16:302

Westerfield, M., Liu, D.W., Kimmel, C.B., and Walker, C. (1990) Pathfinding and synapse formation in a zebrafish mutant lacking functional acetylcholine receptors. Neuron. 4:867-874

Debu B., Frost, D., Westerfield M., Eisen J.S. (1989) Patterning of primary motoneuron axonal outgrowth by extracellular matrix molecules in zebrafish embryos. Soc. Dev. Biol. Mtg. Abstr.

Hanneman, E. and Westerfield, M. (1989) Early expression of acetylcholinesterase activity in functionally distinct neurons of the zebrafish. J. Comp. Neurol.. 284:350-361

Liu, D.W. and Westerfield, M. (1989) Primary motoneurons instruct muscle acetylcholine receptor placement but receptors don't instruct motoneuronal synapse placement in live zebrafish. Soc. Neurosci. Abstr.. 15:1262

Stuart, G.W., McMurray, J.V., and Westerfield, M. (1989) Germ-line transformation of the zebrafish. In Gene Transfer and Gene Therapy, A.L. Beaudet, R. Mulligan, and I. M. Verma, eds., New York, NY, USA: Alan R. Liss, Inc.. 19-28

Westerfield, M. (1989) The Zebrafish Book; A Guide for the Laboratory Use of Zebrafish (Brachydanio rerio). University of Oregon Press, Eugene.

Westerfield, M. (1989) Establishment of cell-specific differences among primary motoneurons in the zebrafish. In The Assembly of the Nervous System. Landmesser, L.T., ed., New York, NY, USA: Alan R. Liss, Inc.. 189-198

Bass, M.B. and Westerfield, M. (1988) Purification of neuron-specific antigens from zebrafish. Soc. Neurosci. Abstr.. 14:1267

Frost, D., Debu B., Eisen J.S., and Westerfield M. (1988) Axonal outgrowth in embryonic zebrafish is perturbed by ectopic localization of fibronectin in vivo. Soc. Dev. Biol. Mtg. Abstr.

Grunwald, D.J., Kimmel, C.B., Westerfield, M., Walker, C., and Streisinger, G. (1988) A neural degeneration mutation that spares primary neurons in the zebrafish. Dev. Biol.. 126:115-128

Hanneman, E., Trevarrow, B., Metcalfe, W.K., Kimmel, C.B., and Westerfield, M. (1988) Segmental pattern of development of the hindbrain and spinal cord of the zebrafish embryo. Development. 103:49-58

Liu, D.W. and Westerfield, M. (1988) Function of identified motoneurones and co-ordination of primary and secondary motor systems during zebra fish swimming. J. Physiol. Lond.. 403:73-89

Stuart, G.W., McMurray, J.V., and Westerfield, M. (1988) Germ-line transformation of the zebrafish Brachydanio-rerio. J. Cell. Biochem.. (Suppl.) 12:195

Stuart, G.W., McMurray, J.V., and Westerfield, M. (1988) Replication, integration and stable germ-line transmission of foreign sequences injected into early zebrafish embryos. Development. 103:403-412

Westerfield, M. and Eisen, J.S. (1988) Neuromuscular specificity: pathfinding by identified motor growth cones in a vertebrate embryo. Trends Neurosci.. 11:18-22

Liu, D.W. and Westerfield, M. (1987) The formation of terminal fields by identified motoneurons in the zebrafish. Anim. Behav.. 35:1875-1882

Westerfield, M. (1987) Substrate interactions affecting motor growth cone guidance during development and regeneration. J. Exp. Biol.. 132:161-176

Westerfield, M. and Eisen, J.S. (1987) Common mechanisms of growth cone guidance during axonal pathfinding. In From Message to Mind: New Directions in the Developmental Neurobiology, Sinauer Assoc.. 110-120

Westerfield, M., Kimmel, C.B., and Walker, C. (1987) Normal pathfinding by pioneer motor growth cones in mutant zebrafish lacking functional acetylcholine receptors. Soc. Neurosci. Abstr.. 13:5

Eisen, J.S., Myers, P.Z., and Westerfield, M. (1986) Pathway selection by growth cones of identified motoneurones in live zebra fish embryos. Nature. 320(6059):269-271

Felsenfeld, A. and Westerfield, M. (1986) Normal pathfinding and synapse formation by motoneurons in a non-motile mutant zebrafish embryo. Soc. Neurosci. Abstr.. 147:12

Frost, D. and Westerfield, M. (1986) Axonal outgrowth of embryonic zebrafish neurons is promoted by laminin and inhibited by fibronectin. Soc. Neurosci. Abstr.. 12:1114

Liu, D. and Westerfield, M. (1986) Coactivation of two motor systems in the zebrafish. Soc. Neurosci. Abstr.. 2:790

Myers, P.Z., Eisen, J.S., and Westerfield, M. (1986) Development and axonal outgrowth of identified motoneurons in the zebrafish. J. Neurosci.. 6:2278-2289

Westerfield, M., Eisen, J.S., Myers, P.Z., McMurray, J.V., and Kimmel, C.B. (1986) Early neurogenesis in the zebrafish. Proc. Int. Union Physiol. Sci.. 16:20

Westerfield, M., McMurray, J.V., and Eisen, J.S. (1986) Identified motoneurons and their innervation of axial muscles in the zebrafish. J. Neurosci.. 6:2267-2277

Eisen, J.S., Myers, P.Z., and Westerfield, M. (1985) Functional interactions between identified growth cones and muscles in embryonic zebrafish. Soc. Neurosci. Abstr.. 11:586

Kimmel, C.B., Grunwald, D.J., Walker, C., Westerfield, M., and Streisinger, G. (1985) Neuronal degeneration mutations that spare primary neurons in the zebrafish. Soc. Neurosci. Abstr.. 11:647

Westerfield, M. and Eisen, J.S. (1985) The growth of motor axons in the spinal cord of Xenopus embryos. Dev. Biol.. 109:96-121

Eisen, J.S., Myers, P.Z., and Westerfield, M. (1984) Segmentally specific growth of motor axons in live zebrafish embryos. Soc. Neurosci. Abstr.. 10:371

Hanneman, E. and Westerfield, M. (1984) Identified neurons produce acetylcholinesterase before they sprout axons in the zebrafish. Soc. Neurosci. Abstr.. 10:1043

Westerfield, M., Myers, P.Z., and Eisen, J.S. (1984) Polyneuronal and intersegmental innervation of body muscles in the zebrafish. Soc. Neurosci. Abstr.. 10:371

Non-Zebrafish Publications:

Westerfield, M., and J.S. Eisen. (1985). The growth of motor axons in the spinal cord of Xenopus embryos. Devel. Biol. 109:96-121.

Powell, S.L., and M. Westerfield. (1984). The absence of specific dye coupling among frog spinal cord neurons. Brain Res. 294:9-14.

Westerfield, M., and S.L. Powell. (1983). Selective reinnervation of limb muscles by regenerating frog motor axons. Devel. Brain Res. 10:301-304.

Frank, E., and M. Westerfield. (1983). Development of sensory-motor synapses in the spinal cord of the frog. J. Physiol. (Lond.) 343:593-610.

Moore, J.W., N. Stockbridge and M. Westerfield. (1983). On the site of impulse initiation in a neurone. J. Physiol. (Lond.) 336:301-311.

Moore, J.W., and M. Westerfield. (1983). Action potential propagation and threshold parameters in inhomogeneous regions of squid axons. J. Physiol. (Lond.) 336:285-300.

Westerfield, M., and E. Frank. (1982). Specificity of electrical coupling among neurons innervating forelimb muscles of the adult bullfrog. J. Neurophysiol. 48:904-913.

Westerfield., M., and R.W. Joyner. (1982). Postsynaptic factors controlling the shape of potentials at the squid giant synapse.
Neuroscience. 7:1367-1376.

Frank, E., and M. Westerfield. (1982). The formation of appropriate central and peripheral connexions by foreign sensory neurones of the bullfrog. J. Physiol. (Lond.) 324:495-505.

Frank, E., and M. Westerfield. (1982). Synaptic organization of sensory and motor neurones innervating triceps brachii muscles in the bullfrog. J. Physiol. (Lond.) 324:479-494.

Joyner, R.W., and M. Westerfield. (1982). The effects of rectification on synaptic efficacy. Biophys. J. 38:3946.

Westerfield, M. and H.D. Lux. (1982). Calcium activated potassium conductance noise in snail neurons. J. Neurobiol. 12:507-517.

Gage, P.W., J.W. Moore and M. Westerfield. (1976) An octopus toxin,
maculotoxin, selectively blocks sodium current in squid axon.
J. Physiol. (Lond.). 259:427-443.

Joyner, R.W., M. Westerfield and J.W. Moore. (1980). The effects of cellular geometry on current flow during action potential propagation. Biophys. J. 31:183-194.

Westerfield, M., J.W. Moore, Y.S. Kim and G. Padilla. (1977). How Gymnodinium breve red tide toxin produces repetitive firing in squid axons. Amer. J. Physiol. 232:23-29.

Westerfield, M., and H.D. Lux. (1979). Two components of membrane conductance noise in snail neuronal somata. Neurosci. Lett. 11:75-80.

Westerfield, M., R.W. Joyner and J.W. Moore. (1978). Temperature sensitive conduction failure at axon branch points. J. Neurophysiol. 41:1-8.

Joyner, R.W., M. Westerfield, J.W. Moore and N. Stockbridge. (1978). A
numerical method to model excitable cells. Biophys. J. 22:155-170.

Ramon, F., J.W. Moore, R.W. Joyner and M. Westerfield (1976) Squid giant axon as a model for the neuron soma? Biophys. J. 16:953-963.

Kim, Y.S., L. Mandel, M. Westerfield, G. Padilla and J.W. Moore. (1975) Effect of Gymnodinium breve toxin(s) on frog skin and giant axon of the squid. Environ. Lett. 9:255-264.