Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-407
Neuhauss, Stephan
Neuhauss Lab
Institute of Molecular Life Sciences
University of Zürich
Winterthurerstrasse 190
Zürich, CH - 8057
Switzerland
Phone: 41-44-635 6040 Email: stephan.neuhauss@imls.uzh.ch
FAX: 41-44-635 6897 URL: http://www.imls.uzh.ch/research/Neuhauss.html
Biography and Research Interests:

1992 M.S. University of Oregon, Eugene (M. Westerfield's Lab)
1992 Dipl. Biol. University Tübingen
1996 Ph.D. MGH Charlestown / University Tübingen (W. Driever's Lab)
1996-2000 Postdoc MPI Tübingen (F. Bonhoeffer's Lab)
2002 Habilitation in Genetics
2000-2003 Junior Group Leader, Brain Research Insitute, ETH Zürich
2003-2005 Förderprofessor for Neuroscience, ETH Zürich
2005 Professor for Neurobiology, Institute of Zoology,
University Zurich
2009 Professor for Neurobiology, Institute of Molecular Life
Sciences, University of Zurich

I am interested in visual system development and function



Publications:
Mueller, K.P., and Neuhauss, S.C. (2010) Quantitative Measurements of the Optokinetic Response in Adult Fish. J. Neurosci. Meth.. 186(1):29-34
Schonthaler, H.B., Franz-Odendaal, T.A., Hodel, C., Gehring, I., Geisler, R., Schwarz, H., Neuhauss, S.C., and Dahm, R. (2010) The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness. Mech. Dev.. :
Froehlicher, M., Liedtke, A., Groh, K., Lopez-Schier, H., Neuhauss, S.C., Segner, H., and Eggen, R.I. (2009) Estrogen receptor subtype beta2 is involved in neuromast development in zebrafish (Danio rerio) larvae. Dev. Biol.. 330(1):32-43
Froehlicher, M., Liedtke, A., Groh, K.J., Neuhauss, S.C., Segner, H., and Eggen, R.I. (2009) Zebrafish (Danio rerio) neuromast: Promising biological endpoint linking developmental and toxicological studies. Aquat. Toxicol.. 95(4):307-319
Huang, Y.Y., Tschopp, M., and Neuhauss, S.C. (2009) Illusionary self-motion perception in zebrafish. PLoS One. 4(8):e6550
Aleström, P., Begemann, G., Carvan, M.J. 3rd, Cheng, K.C., Crosier, K., Crosier, P., Ekker, S., Huttenlocher, A., Kawakami, K., Kelly, G., Korzh, V., Lieschke, G., Mione, M., Neely, M.N., Neuhauss, S., and Trede, N.S. (2008) Views on four key questions about zebrafish research. Zebrafish. 5(1):9-24
Fleisch, V.C., Schonthaler, H.B., von Lintig, J., and Neuhauss, S.C. (2008) Subfunctionalization of a retinoid-binding protein provides evidence for two parallel visual cycles in the cone-dominant zebrafish retina. J. Neurosci.. 28(33):8208-8216
Huang, Y.Y., and Neuhauss, S.C. (2008) The optokinetic response in zebrafish and its applications. Front. Biosci.. 13(1):1899-1916
Schonthaler, H.B., Fleisch, V.C., Biehlmaier, O., Makhankov, Y., Rinner, O., Bahadori, R., Geisler, R., Schwarz, H., Neuhauss, S.C., and Dahm, R. (2008) The zebrafish mutant lbk/vam6 resembles human multi-systemic disorders caused by aberrant trafficking of endosomal vesicles. Development. 135(2):387-399
Biehlmaier, O., Makhankov, Y., and Neuhauss, S.C. (2007) Impaired retinal differentiation and maintenance in zebrafish laminin mutants. Invest. Ophthalmol. Vis. Sci.. 48(6):2887-2894
Kallivretaki, E., Eggen, R.I., Neuhauss, S.C., Kah, O., and Segner, H. (2007) The zebrafish, brain-specific, aromatase cyp19a2 is neither expressed nor distributed in a sexually dimorphic manner during sexual differentiation. Dev. Dyn.. 236(11):3155-3166
Geisler, R., Rauch, G.J., Geiger-Rudolph, S., Albrecht, A., van Bebber, F., Berger, A., Busch-Nentwich, E., Dahm, R., Dekens, M.P., Dooley, C., Elli, A.F.,Gehring, I., Geiger, H., Geisler, M., Glaser, S., Holley, S., Huber, M., Kerr, A., Kirn, A., Knirsch, M., Konantz, M., Kuchler, A.M., Maderspacher, F., Neuhauss, S.C., Nicolson, T., Ober, E.A., Praeg, E., Ray, R., Rentzsch, B., Rick, J.M., Rief, E., Schauerte, H.E., Schepp, C.P., Schonberger, U., Schonthaler, H.B., Seiler, C., Sidi, S., Söllner, C., Wehner, A., Weiler, C., Nusslein-Volhard, C. (2007) Large-scale mapping of mutations affecting zebrafish development. BMC Genomics. 8(1):11
Schonthaler, H.B., Lampert, J.M., Isken, A., Rinner, O., Mader, A., Gesemann, M., Oberhauser, V., Golczak, M., Biehlmaier, O., Palczewski, K., Neuhauss, S.C., and von Lintig, J. (2007) Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. Eur. J. Neurosci.. 26(7):1940-1949
Bahadori, R., Biehlmaier, O., Zeitz, C., Labhart, T., Makhankov, Y.V., Forster, U., Gesemann, M., Berger, W., and Neuhauss, S.C. (2006) Nyctalopin is essential for synaptic transmission in the cone dominated zebrafish retina. Eur. J. Neurosci.. 24(6):1664-1674
Bahadori, R., Rinner, O., Schonthaler, H.B., Biehlmaier, O., Makhankov, Y.V., Rao, P., Jagadeeswaran, P., and Neuhauss, S.C. (2006) The Zebrafish fade out Mutant: A Novel Genetic Model for Hermansky-Pudlak Syndrome. Invest. Ophthalmol. Vis. Sci.. 47(10):4523-4531
Fleisch, V.C., and Neuhauss, S.C.F. (2006) Visual Behavior in Zebrafish. Zebrafish. 3(2):191-201
Hodel, C., Neuhauss, S.C., and Biehlmaier, O. (2006) Time course and development of light adaptation processes in the outer zebrafish retina. Anat. Rec. A Discov. Mol. Cell. Evol. Biol.. 288(6):653-662
Huang, Y.Y., Rinner, O., Hedinger, P., Liu, S.C., and Neuhauss, S.C. (2006) Oculomotor instabilities in zebrafish mutant belladonna: a behavioral model for congenital nystagmus caused by axonal misrouting. J. Neurosci.. 26(39):9873-9880
Kallivretaki, E., Eggen, R., Neuhauss, S., Alberti, M., Kausch, U., and Segner, H. (2006) Aromatase in zebrafish: A potential target for endocrine disrupting chemicals. Mar. Environ. Res.. 62 Suppl 1:S187-90
Ninkovic, J., Folchert, A., Makhankov, Y.V., Neuhauss, S.C., Sillaber, I., Straehle, U., and Bally-Cuif, L. (2006) Genetic identification of AChE as a positive modulator of addiction to the psychostimulant D-amphetamine in zebrafish. J. Neurobiol.. 66(5):463-475
Seth, A., Culverwell, J., Walkowicz, M., Toro, S., Rick, J.M., Neuhauss, S.C., Varga, Z.M., and Karlstrom, R.O. (2006) belladonna/(lhx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain. Development. 133(4):725-735
Rinner, O., Makhankov, Y.V., Biehlmaier, O., and Neuhauss, S.C. (2005) Knockdown of Cone-Specific Kinase GRK7 in Larval Zebrafish Leads to Impaired Cone Response Recovery and Delayed Dark Adaptation. Neuron. 47(2):231-242
Rinner, O., Rick, J.M., and Neuhauss, S.C. (2005) Contrast sensitivity, spatial and temporal tuning of the larval zebrafish optokinetic response. Invest. Ophthalmol. Vis. Sci.. 46(1):137-142
Schonthaler, H.B., Lampert, J.M., von Lintig, J., Schwarz, H., Geisler, R., and Neuhauss, S.C. (2005) A mutation in the silver gene leads to defects in melanosome biogenesis and alterations in the visual system in the zebrafish mutant fading vision. Dev. Biol.. 284(2):421-436
Seiler, C., Finger-Baier, K.C., Rinner, O., Makhankov, Y.V., Schwarz, H., Neuhauss, S.C., and Nicolson, T. (2005) Duplicated genes with split functions: independent roles of protocadherin15 orthologues in zebrafish hearing and vision. Development. 132(3):615-623
Trueb, B., Neuhauss, S.C., Baertschi, S., Rieckmann, T., Schild, C., and Taeschler, S. (2005) Fish possess multiple copies of fgfrl1, the gene for a novel FGF receptor. Biochim. Biophys. Acta.. 1727(1):65-74
Makhankov, Y.V., Rinner, O., and Neuhauss, S.C. (2004) An inexpensive device for non-invasive electroretinography in small aquatic vertebrates. Neurosci. Methods. 135(1-2):205-210
Bahadori, R., Huber, M., Rinner, O., Seeliger, M.W., Geiger-Rudolph, S., Geisler, R., and Neuhauss, S.C. (2003) Retinal function and morphology in two zebrafish models of oculo-renal syndromes. Eur. J. Neurosci.. 18(6):1377-1386
Biehlmaier, O., Neuhauss, S.C., and Kohler, K. (2003) Double cone dystrophy and RPE degeneration in the retina of the zebrafish gnn mutant. Invest. Ophthalmol. Vis. Sci.. 44(3):1287-1298
Biehlmaier, O., Neuhauss, S.C.F., and Kohler, K. (2003) Synaptic plasticity and functionality at the cone terminal of the developing zebrafish retina. J. Neurobiol.. 56(3):222-236
Neuhauss, S.C. (2003) Behavioral genetic approaches to visual system development and function in zebrafish. J. Neurobiol.. 54(1):148-160
Neuhauss, S.C., Seeliger, M.W., Schepp, C.P., and Biehlmaier, O. (2003) Retinal defects in the zebrafish bleached mutant. Doc. Ophthalmol.. 107(1):71-78
Seeliger, M.W., Rilk, A., and Neuhauss, S.C.F. (2002) Ganzfeld ERG in zebrafish larvae. Doc. Ophthalmol.. 104(1):57-68
Biehlmaier, O., Neuhauss, S.C.F., and Kohler, K. (2001) Onset and time course of apoptosis in the developing retina of zebrafish. Invest. Ophthalmol. Vis. Sci.. 42(4):3407
Biehlmaier, O., Neuhauss, S.C.F., and Kohler, K. (2001) Onset and time course of apoptosis in the developing zebrafish retina. Cell Tissue Res.. 306:199-207
Gnuegge, L., Schmid, S., and Neuhauss, S.C.F. (2001) Analysis of the activity-deprived zebrafish mutant macho reveals an essential requirement of neuronal activity for the development of a fine-grained visuotopic map. J. Neurosci.. 21(10):3542-3548
Biehlmaier, O., Neuhauss, S.C.F., Werts, D., and Kohler, K. (2000) Visual mutant zebrafish express morphological abnormalities during retinal development. Eur. J. Neurosci.. 12:487
Rick, J.M., Horschke, I., and Neuhauss, S.C. (2000) Optokinetic behavior is reversed in achiasmatic mutant zebrafish larvae. Curr. Biol.. 10(10):595-598
Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nat. Genet.. 23(1):86-89
Neuhauss, S.C.F., Biehlmaier, O., Seeliger, M.W., Das, T., Kohler, K., Harris, W.A., and Baier, H. (1999) Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. J. Neurosci.. 19(19):8603-8615
Drummond, I.A., Majumdar, A., Hentschel, H., Elger, M., Solnica-Krezel, L., Schier, A.F., Neuhauss, S.C., Stemple, D.L., Zwartkruis, F., Rangini, Z., Driever, W., and Fishman, M.C. (1998) Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development. 125:4655-4667
Knapik, E.W., Goodman, A., Ekker, M., Chevrette, M., Delgado, J., Neuhauss, S., Shimoda, N., Driever, W., Fishman, M.C., and Jacob, H.J. (1998) A microsatellite genetic linkage map for zebrafish (Danio rerio). Nature Genet.. 18:338-343
Marlow, F., Zwartkruis, F., Malicki, J., Neuhauss, S.C.F., Abbas, L., Weaver, M., Driever, W., and Solnica-Krezel, L. (1998) Functional interactions of genes mediating convergent extension, knypek and trilobite, during the partitioning of the eye primordium in zebrafish. Dev. Biol.. 203:382-399
Seeliger, M., Neuhauss, S.C.F., Kohler, K., and Zrenner, E. (1998) Ganzfeld electroretinography in the zebrafish (Danio rerio). Invest. Ophthalmol. Vis. Sci.. 39:975
Talbot, W.S., Egan, E.S., Gates, M.A., Walker, C., Ullmann, B., Neuhauss, S.C.F., Kimmel, C.B., and Postlethwait, J.H. (1998) Genetic analysis of chromosomal rearrangements in the cyclops region of the zebrafish genome. Genetics. 148:373-380
Schier, A.F., Neuhauss, S.C.F., Helde, K.A., Talbot, W.S., and Driever, W. (1997) The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail. Development. 124(2):327-342
Abdelilah, S., Mountcastle-Shah, E., Harvey, M., Solnica-Krezel, L., Schier, A.F., Stemple, D.L., Malicki, J., Neuhauss, S.C., Zwartkruis, F., Stainier, D.Y., Rangini, Z., and Driever, W. (1996) Mutations affecting neural survival in the zebrafish, Danio rerio. Development. 123:217-227
Driever, W., Solnica-Krezel, L., Schier, A.F., Neuhauss, S.C., Malicki, J., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Abdelilah, S., Rangini, Z., Belak, J., and Boggs, C. (1996) A genetic screen for mutations affecting embryogenesis in zebrafish. Development. 123:37-46
Malicki, J., Neuhauss, S.C., Schier, A.F., Solnica-Krezel, L., Stemple, D.L., Stainier, D.Y., Abdelilah, S., Zwartkruis, F., Rangini, Z., and Driever, W. (1996) Mutations affecting development of the zebrafish retina. Development. 123:263-273
Malicki, J., Schier, A.F., Solnica-Krezel, L., Stemple, D.L., Neuhauss, S.C., Stainier, D.Y., Abdelilah, S., Rangini, Z., Zwartkruis, F., and Driever, W. (1996) Mutations affecting development of the zebrafish ear. Development. 123:275-283
Neuhauss, S.C., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D.L., Malicki, J., Abdelilah, S., Stainier, D.Y., and Driever, W. (1996) Mutations affecting craniofacial development in zebrafish. Development. 123:357-367
Pack, M., Solnica-Krezel, L., Malicki, J., Neuhauss, S.C., Schier, A-, F., Stemple, D.L., Driever, W., and Fishman, M.C. (1996) Mutations affecting development of zebrafish digestive organs. Development. 123:321-328
Schier, A.F., Neuhauss, S.C., Harvey, M., Malicki, J., Solnica-Krezel, L., Stainier, D.Y., Zwartkruis, F., Abdelilah, S., Stemple, D.L., Rangini, Z., Yang, H., and Driever, W. (1996) Mutations affecting the development of the embryonic zebrafish brain. Development. 123:165-178
Solnica-Krezel, L., Stemple, D.L., Mountcastle-Shah, E., Rangini, Z., Neuhauss, S.C., Malicki, J., Schier, A.F., Stainier, D.Y., Zwartkruis, F., Abdelilah, S., and Driever, W. (1996) Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish. Development. 123:67-80
Stainier, D.Y., Fouquet, B., Chen, J.N., Warren, K.S., Weinstein, B.M., Meiler, S.E., Mohideen, M.A., Neuhauss, S.C., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D.L., Malicki, J., Driever, W., and Fishman, M.C. (1996) Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development. 123:285-292
Stemple, D.L., Solnica-Krezel, L., Zwartkruis, F., Neuhauss, S.C., Schier, A.F., Malicki, J., Stainier, D.Y., Abdelilah, S., Rangini, Z., Mountcastle-Shah, E., and Driever, W. (1996) Mutations affecting development of the notochord in zebrafish. Development. 123:117-128
Yelick, P.C., Driever, W., Neuhauss, S., and Stashenko, P. (1996) Craniofacial cartilage development in zebrafish. Ann. N.Y. Acad. Sci.. 785:360-361
Brockerhoff, S.E., Hurley, J.B., Janssen-Bienhold, U., Neuhauss, S.C.F., Driever, W., and Dowling, J.E. (1995) A behavioral screen for isolating zebrafish mutants with visual system defects. Proc. Natl. Acad. Sci. USA. 92:10545-10549
Neuhauss, S. (1992) Early development of germ cells and alkaline phosphatase activity in zebrafish embryos. M.S. Thesis, University of Oregon.

Non-Zebrafish Publications:

Zanotelli VR, Neuhauss SC, Ehrengruber MU. Long-term exposure to bis(2-ethylhexyl)phthalate (DEHP) inhibits growth of guppy fish (Poecilia reticulata). J Appl Toxicol. 2010 Jan;30(1):29-33.