Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-257
Houart, Corinne
Houart Lab
MRC Centre for Developmental Neurobiology
King's College London
Guy's Hospital Campus
4th floor, New Hunt's House
London, SE1 9RT
United Kingdom
Phone: 44-207-848-6409 Email: corinne.houart@kcl.ac.uk
FAX: 44-207-848-6550 URL: http://www.kcl.ac.uk/depsta/biomedical/mrc/ResearchGroup.php?GroupID=16
Biography and Research Interests:

My main interest in the field is the development of the vertebrate forebrain. In particular, the early events leading to the patterning and organisation of the anterior neural plate into telencephalic and diencephalic territories. Although the zebrafish is our principal model organism, a set of experiments in other vertebrates will be undertaken to address evolutionary issues.

Publications:
Paridaen, J.T., Danesin, C., Elas, A.T., van de Water, S., Houart, C., and Zivkovic, D. (2009) Apc1-Mediated Antagonism of Wnt/beta-Catenin Signaling Is Required for Retino-Tectal Pathfinding in the Zebrafish. Zebrafish. 6(1):41-47
Russek-Blum, N., Gutnick, A., Nabel-Rosen, H., Blechman, J., Staudt, N., Dorsky, R.I., Houart, C., and Levkowitz, G. (2008) Dopaminergic neuronal cluster size is determined during early forebrain patterning. Development. 135(20):3401-3413
Caneparo, L., Huang, Y.L., Staudt, N., Tada, M., Ahrendt, R., Kazanskaya, O., Niehrs, C., and Houart, C. (2007) Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/betacatenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek. Genes Dev.. 21(4):465-480
McCormick, L.J., Hutt, J.A., Hazan, J., Houart, C., and Cohen, J. (2007) The homeodomain transcription factor drg11 is expressed in primary sensory neurons and their putative CNS targets during embryonic development of the zebrafish. Gene Expr. Patterns. 7(3):289-296
Scholpp, S., Foucher, I., Staudt, N., Peuckert, D., Lumsden, A., and Houart, C. (2007) Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon. Development. 134(17):3167-3176
Staudt, N., and Houart, C. (2007) The prethalamus is established during gastrulation and influences diencephalic regionalization. PLoS Biol.. 5(4):e69
Foucher, I., Mione, M., Simeone, A., Acampora, D., Bally-Cuif, L., and Houart, C. (2006) Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants. Development. 133(10):1891-1900
Stigloher, C., Ninkovic, J., Laplante, M., Geling, A., Tannhauser, B., Topp, S., Kikuta, H., Becker, T.S., Houart, C., and Bally-Cuif, L. (2006) Segregation of telencephalic and eye-field identities inside the zebrafish forebrain territory is controlled by Rx3. Development. 133(15):2925-2935
Tendeng, C., and Houart, C. (2006) Cloning and embryonic expression of five distinct sfrp genes in the zebrafish Danio rerio. Gene Expr. Patterns. 6(8):761-771
Cavodeassi, F., Carreira-Barbosa, F., Young, R., Concha, M., Allende, M.L., Houart, C., Tada, M., and Wilson, S. (2005) Early Stages of Zebrafish Eye Formation Require the Coordinated Activity of Wnt11, Fz5, and the Wnt/Catenin Pathway. Neuron. 47(1):43-56
Norton, W.H., Mangoli, M., Lele, Z., Pogoda, H.M., Diamond, B., Mercurio, S., Russell, C., Teraoka, H., Stickney, H.L., Rauch, G.J., Heisenberg, C.P., Houart, C., Schilling, T.F., Frohnhoefer, H.G., Rastegar, S., Neumann, C.J., Gardiner, R.M., Strähle, U., Geisler, R., Rees, M., Talbot, W.S., and Wilson, S.W. (2005) Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones. Development. 132(4):645-658
Kapsimali, M., Caneparo, L., Houart, C., and Wilson, S.W. (2004) Inhibition of Wnt/Axin/{beta}-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity. Development. 131(23):5923-5933
Kudoh, T., Concha, M.L., Houart, C., Dawid, I.B., and Wilson, S.W. (2004) Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains. Development. 131(15):3581-3592
Yu, H.H., Houart, C., and Moens, C.B. (2004) Cloning and embryonic expression of zebrafish neuropilin genes. Gene Expr. Patterns. 4(4):371-378
Grandel, H., Lun, K., Rauch, G.J., Rhinn, M., Piotrowski, T., Houart, C., Sordino, P., Küchler, A.M., Schulte-Merker, S., Geisler, R., Holder, N., Wilson, S.W., and Brand, M. (2002) Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud. Development. 129(12):2851-2865
Houart, C., Caneparo, L., Heisenberg, C.P., Barth, K.A., Take-uchi, M., and Wilson, S.W. (2002) Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. 35(2):255-265
Heisenberg, C.P., Houart, C., Take-uchi, M., Rauch, G.J., Young, N., Coutinho, P., Masai, I., Caneparo, L., Concha, M.L., Geisler, R., Dale, T.C., Wilson, S.W., and Stemple, D.L. (2001) A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes Dev.. 15(11):1427-1434
Shanmugalingam, S., Houart, C., Picker, A., Reifers, F., Macdonald, R., Barth, A., Griffin, K., Brand, M., and Wilson, S.W. (2000) Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon. Development. 127(12):2549-2561
Ho, C.Y., Houart, C., Wilson, S.W., and Stainier, D.Y. (1999) A role for the extraembryonic yolk syncytial layer in patterning the zebrafish embryo suggested by properties of the hex gene. Curr. Biol.. 9(19):1131-1134
Houart, C., M. Westerfield, and S.W. Wilson (1998) A small population of anterior cells patterns the forebrain during gastrulation. Nature. 391:788-792
Furutani-Seiki, M., Jiang, Y.J., Brand, M., Heisenberg, C.P., Houart, C., Beuchle, D., van Eeden, F.J.M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Neural degeneration mutants in the zebrafish, Danio rerio. Development. 123:229-239

Non-Zebrafish Publications: