Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-21
Akimenko, Marie-Andree
Akimenko Lab
Loeb Health Research Institute
Ottawa Civic Hospital
725 Parkdale Avenue
Ottawa, Ontario, K1Y 4E9
Canada
Phone: (613) 562 5800 ext 7399 Email: makimen@uottawa.ca
FAX: (613) 562 5486 URL: http://www.careg.uottawa.ca/bio_marie_andree_akimenko.htm
Biography and Research Interests:

Publications:
Khatib, A.M., Lahlil, R., Scamuffa, N., Akimenko, M.A., Ernest, S., Lomri, A., Lalou, C., Seidah, N.G., Villoutreix, B.O., Calvo, F., and Siegfried, G. (2010) Zebrafish ProVEGF-C Expression, Proteolytic Processing and Inhibitory Effect of Unprocessed ProVEGF-C during Fin Regeneration. PLoS One. 5(7):e11438
Zhang, J., Wagh, P., Guay, D., Sanchez-Pulido, L., Padhi, B.K., Korzh, V., Andrade-Navarro, M.A., and Akimenko, M.A. (2010) Loss of fish actinotrichia proteins and the fin-to-limb transition. Nature. 466(7303):234-237
Avaron, F., Smith, A., and Akimenko, M.A. (2008) Sonic Hedgehog Signalling in the Developing and Regenerating Fins of Zebrafish. Mol. Biol. Int. Unit. 93-106
Smith, A., Zhang, J., Guay, D., Quint, E., Johnson, A., and Akimenko, M.A. (2008) Gene expression analysis on sections of zebrafish regenerating fins reveals limitations in the whole-mount in situ hybridization method. Dev. Dyn.. 237(2):417-425
Murciano, C., Pérez-Claros, J., Smith, A., Avaron, F., Fernández, T.D., Durán, I., Ruiz-Sánchez, J., García, F., Becerra, J., Akimenko, M.A., and Marí-Beffa, M. (2007) Position dependence of hemiray morphogenesis during tail fin regeneration in Danio rerio. Dev. Biol.. 312(1):272-283
Avaron, F., Hoffman, L., Guay, D., and Akimenko, M.A. (2006) Characterization of two new zebrafish members of the hedgehog family: Atypical expression of a zebrafish indian hedgehog gene in skeletal elements of both endochondral and dermal origins. Dev. Dyn.. 235(2):478-489
Padhi, B.K., Akimenko, M.A., and Ekker, M. (2006) Independent expansion of the keratin gene family in teleostean fish and mammals: An insight from phylogenetic analysis and radiation hybrid mapping of keratin genes in zebrafish. Gene. 368:37-45
Smith, A., Avaron, F., Guay, D., Padhi, B.K., and Akimenko, M.A. (2006) Inhibition of BMP signaling during zebrafish fin regeneration disrupts fin growth and scleroblast differentiation and function. Dev. Biol.. 299(2):438-454
Padhi, B.K., Joly, L., Tellis, P., Smith, A., Nanjappa, P., Chevrette, M., Ekker, M., and Akimenko, M.A. (2004) Screen for genes differentially expressed during regeneration of the zebrafish caudal fin. Dev. Dyn.. 231(3):527-541
Sire, J.Y., and Akimenko, M.A. (2004) Scale development in fish: a review, with description of sonic hedgehog (shh) expression in the zebrafish (Danio rerio). Int. J. Dev. Biol.. 48(2-3):233-246
Akimenko, M.-A., Marí-Beffa, M., Becerra, J., and Géraudie, J. (2003) Old questions, new tools, and some answers to the mystery of fin regeneration. Dev. Dyn.. 226(2):190-201
Schoft, V.K., Beauvais, A.J., Lang, C., Gajewski, A., Prufert, K., Winkler, C., Akimenko, M.-A., Paulin-Levasseur, M., and Krohne, G. (2003) The lamina-associated polypeptide 2 (LAP2) isoforms {beta}, {gamma} and {omega} of zebrafish: developmental expression and behavior during the cell cycle. J. Cell Sci.. 116(12):2505-2517
Hoffman, L., Miles, J., Avaron, F., Laforest, L., and Akimenko, M.-A. (2002) Exogenous retinoic acid induces a stage-specific, transient and progressive extension of Sonic hedgehog expression across the pectoral fin bud of zebrafish. Int. J. Dev. Biol.. 46(7):949-956
Murciano,C., Fernández, T.D., Durán, I., Maseda, D., Riuz-Sánchez, J., Becerra, J., Akimenko, M.-A., and Marí-Beffa, M. (2002) Ray-interray interactions during fin regeneration of Danio rerio. Dev. Biol.. 252(2):4-224
Quint, E., Smith, A., Avaron, F., Laforest, L., Miles, J., Gaffield, W., and Akimenko, M.-A. (2002) Bone patterning is altered in the regenerating zebrafish caudal fin after ectopic expression of sonic hedgehog and bmp2b or exposure to cyclopamine. Proc. Natl. Acad. Sci. USA. 99(13):8713-8718
Cadieux, B., James, S., Fryer, J.N., Ekker, M., Akimenko, M.-A., and Bennett, H.P.J. (2001) Characterization and tissue distribution of zebrafish granulins: Growth factors with possible roles in development and fin regeneration. FASEB J.. 15(5):A746
Poleo, G., Brown, C.W., Laforest, L., and Akimenko, M.A. (2001) Cell proliferation and movement during early fin regeneration in zebrafish.. Dev. Dyn.. 221(4):380-390
Boue-Grabot, E., Akimenko, M.-A., and Seguela, P. (2000) Unique functional properties of a novel developmentally-regulated neuronal P2X ATP-gated channel from zebrafish. Eur. J. Neurosci.. 12:452
Boué-Grabot, E., Akimenko, M.A., and Séguéla, P. (2000) Unique functional properties of a sensory neuronal P2X ATP-gated channel from zebrafish. J. Neurochem.. 75(4):1600-1607
Martin, C.C., Laforest, L., Akimenko, M.-A., and Ekker, M. (1999) A role for DNA methylation in gastrulation and somite patterning. Dev. Biol.. 206:189-205
Monnot, M.J., Babin, P.J., Poleo, G., Andre, M., Laforest, L., Ballagny, C., and Akimenko, M.A. (1999) Epidermal expression of apolipoprotein E gene during fin and scale development and fin regeneration in zebrafish. Dev. Dyn.. 214(3):207-215
Wang, J.M., Prefontaine, G.G., Lemieux, M.E., Pope, L., Akimenko, M.A., and Hache, R.J. (1999) Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding. Mol. Cell. Biol.. 19(10):7106-7122
Akimenko, M.-A. and Cold Spring Harbor Laboratory (1998) Abstracts of papers presented at the 1998 meeting on zebrafish development & genetics, April 29-May 3, 1998. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory. 318 p
Laforest, L., Brown, C.W., Poleo, G., Géraudie, J., Tada, M., Ekker, M., and Akimenko, M.-A. (1998) Involvement of the Sonic hedgehog, patched 1, and bmp2 genes in patterning of the zebrafish dermal fin rays. Development. 125:4175-4184
Babin, P.J., Thisse, C., Durliat, M., Andre, M., Akimenko, M.-A., and Thisse, B. (1997) Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development. Proc. Natl. Acad. Sci. USA. 94(16):8622-8627
Ekker, M., Akimenko, M.-A., Allende, M.L., Smith, R., Drouin, G., Langille, R.M., Weinberg, E.S., and Westerfield, M. (1997) Relationships among msx gene structure and function in zebrafish and other vertebrates. Mol. Biol. Evol.. 14:1008-1022
Ellies, D.L., Langille, R.M., Martin, C.C., Akimenko, M.A., and Ekker, M. (1997) Specific craniofacial cartilage dysmorphogenesis coincides with a loss of dlx gene expression in retinoic acid-treated zebrafish embryos. Mech. Dev.. 61(1-2):23-36
Akimenko, M.A. and Ekker, M. (1995) Anterior duplication of the Sonic hedgehog expression pattern in the pectoral fin buds of zebrafish treated with retinoic acid. Dev. Biol.. 170:243-247
Akimenko, M.A., Johnson, S.L., Westerfield, M., and Ekker, M. (1995) Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish. Development. 121:347-357
Akimenko, M.A., Ekker, M., Wegner, J., Lin, W., and Westerfield, M. (1994) Combinatorial expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head. J. Neurosci.. 14:3475-3486
Westerfield, M., Akimenko, M.A., Ekker, M., and Püschel, A. (1993) Eyes, ears and homeobox genes in zebrafish embryos. In Molecular Basis of Morphogenesis, M. Bernfield, ed., New York, NY: John Wiley & Sons, Wiley-Liss Division. 67-75
Ekker, M., Akimenko, M.A., BreMiller, R., and Westerfield, M. (1992) Regional expression of three homeobox transcripts in the inner ear of zebrafish embryos. Neuron. 9:27-35
Ekker, M., Wegner, J., Akimenko, M.A., and Westerfield, M. (1992) Coordinate embryonic expression of three zebrafish engrailed genes. Development. 116:1001-1010
Ekker, M. and Akimenko, M.A. (1991) Embryology and genetics of the zebrafish, Brachydanio rerio. Int. J. Bio. Med.. 7:553-560
Ekker, M., Akimenko, M.A., BreMiller, R., and Westerfield, M. (1991) Characterization of four homeobox genes expressed in zebrafish neural crest. Soc. Neurosci. Abstr.. 17:924
Westerfield, M., Wegner, J., Akimenko, M., Ekker, M., Eisen, J., and Halpern, M. (1991) A role for engrailed gene in zebrafish muscle patterning. Soc. Neurosci. Abstr.. 17:761
Akimenko, M.A., Ekker, M., and Westerfield, M. (1990) Characterization of three zebrafish genes related to Hox-7. In Developmental Patterning of the Vertebrate Limb, J.R. Hinchliffe, J. Hurle and D. Summerbell, eds., New York: Plenum Press. 61-63

Non-Zebrafish Publications: