Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-030612-2
Howe, Ph.D., Doug
ZFIN Database Team
Zebrafish Information Network
5291 University of Oregon
Eugene, OR
97403-5291
USA
Phone: (541) 346-0120 Email: dhowe@zfin.org
FAX: (541) 346-4548 URL:
Biography and Research Interests:

Education & Postdoctoral Training
1998-2003 Postdoctoral Fellow
Department of Pharmacology
University of Washington
Seattle, WA
Molecular and Behavioral Analysis of the role of PKA in Neuronal and Glial Signal Transduction In Vivo

1992-1998 Ph.D., Neurobiology
University of North Carolina
Chapel Hill, NC
Signal Transduction in Neurons and Glia

1988-1992 B.S. Biology
University of New Hampshire
Durham, New Hampshire

2001-2002 Computer Programming Courses
North Seattle Community College
Seattle, WA


Publications:
Sprague, J., Bayraktaroglu, L., Bradford, Y., Conlin, T., Dunn, N., Fashena, D., Frazer, K., Haendel, M., Howe, D.G., Knight, J., Mani, P., Moxon, S.A., Pich, C., Ramachandran, S., Schaper, K., Segerdell, E., Shao, X., Singer, A., Song, P., Sprunger, B., Van Slyke, C.E., and Westerfield, M. (2008) The Zebrafish Information Network: the zebrafish model organism database provides expanded support for genotypes and phenotypes. Nucleic Acids Res.. 36:D768-772
Sprague, J., Bayraktaroglu, L., Clements, D., Conlin, T., Fashena, D., Frazer, K., Haendel, M., Howe, D.G., Mani, P., Ramachandran, S., Schaper, K., Segerdell, E., Song, P., Sprunger, B., Taylor, S., Van Slyke, C.E., and Westerfield, M. (2006) The Zebrafish Information Network: the zebrafish model organism database. Nucleic Acids Res.. 34:D581-585

Non-Zebrafish Publications:

Hirschman J, Berardini TZ, Drabkin H, Howe D (2010) A MOD(ern) perspecive on literature curation. Mol. Genet. Genomics 283(5):415-425.

Su, AI, Howe, DG (2010) Mining the Gene Wiki to prioritize literature curation efforts. The Future of the Web for Collaborative Science 2010

Hill DP, Berardini TZ, Howe DG, Van Auken KM (2010) Representing ontogeny through ontology: A developmental biologist's guide to the gene ontology. Mol. Reprod. Dev. 77(4):314-329.

LePendu P., Dou D., Howe, D. (2009) Detecting Inconsistencies in the Gene Ontology Using Ontology Databases with Not-gadgets. Lecture Notes in Computer Science 5871:948-965.

The Reference Genome Group of the Gene Ontology Consortium (2009) The Gene Ontology’s Reference Genome Project: A Unified Framework for Functional Annotation across Species. PLoS Comput. Biol. 5(7): e1000431. doi:10.1371/journal.pcbi.1000431

Howe DG, Costanzo M, Fey P, Gojobori T, Hannick L, Hide, W, Hill DP, Kania R, Schaeffer M, St Pierre S, Twigger S, White O, Rhee SY (2008) Big Data: The future of biocuration. Nature 455:47-50.

Gene Ontology Consortium (2006) The Gene Ontology (GO) project in 2006. Nucleic Acids Research 34 (Database issue):D322-D326.

Howe DG, Clark CM, Yan H, Willis BS, Schneider DA, McKnight GS, Kapur RP (2005) Inhibition of Protein Kinase A in Murine Enteric Neurons Causes Lethal Intestinal Pseudo-obstruction. J. Neurobiology 66:256-272.

Kapur RP, Clarke CM, Doggett B, Taylor BE, Baldessari A, Parisi MA, Howe, DG (2005) Hox11L1 expression by precursors of enteric smooth muscle: an alternative explanation for megacecum in Hox11L1 -/- mice. Pediatr. Dev. Pathol. 8:148-161.

Amieux PS, Howe DG, Knickerbocker H, Lee DC, Su T, Laszlo GS, Idzerda RL, McKnight GS (2002). Increased basal PKA activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J.Biol.Chem. 277(30): 27294-304.

Howe DG,Wiley JC, and McKnight GS (2002). Molecular and behavioral effects of a null mutation in all PKA Cbeta isoforms. Mol.Cell.Neurosci. 20(3): 515-524.

Howe DG and McCarthy KD (2000). Retroviral inhibition of Schwann cell cyclic AMP-dependent protein kinase inhibits myelination but not mitosis stimulated by interaction with neurons. J. Neurosci. 20(10):3513-3521.

Howe DG and McCarthy KD (1998). A dicistronic retroviral vector and culture model for analysis of neuron-Schwann cell interactions. J. Neurosci. Methods 83(2): 133-142.

He M, Howe DG and McCarthy KD (1996). Oligodendroglial signal transduction systems are regulated by neuronal contact. J. Neurochem. 67(4): 1491-1499.

Fagerberg WR and Howe DG (1996). A quantitative study of tissue dynamics in venuses flytrap Dionaea muscipula (Droseraceae). II. Trap reopening. American J. Botany. 83(7): 836-842.