Gene
svila
- ID
- ZDB-GENE-990706-5
- Name
- supervillin a
- Symbol
- svila Nomenclature History
- Previous Names
-
- svil
- sb:cb867
- wu:fd05a09
- zmp:0000000648 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within cytoskeleton organization. Predicted to be located in cytoskeleton and membrane. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including adaxial cell; cardiovascular system; musculature system; optic vesicle; and sensory system. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb867 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Deo et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myofibrillar myopathy 10 | Alliance | Myofibrillar myopathy 10 | 619040 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ADF-H/Gelsolin-like domain superfamily | Gelsolin-like domain | Villin/Gelsolin | Villin headpiece | Villin headpiece domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q864 | InterPro | 2239 | |||||
| UniProtKB:A0A8M9QII8 | InterPro | 2264 | |||||
| UniProtKB:A0A8M9QE30 | InterPro | 2208 | |||||
| UniProtKB:A0A8M9PW23 | InterPro | 2241 | |||||
| UniProtKB:A0A8M9QIJ4 | InterPro | 1847 | |||||
| UniProtKB:A0A8M9QMC6 | InterPro | 1919 | |||||
| UniProtKB:Q38HW9 | InterPro | 1763 | |||||
| UniProtKB:F1Q6K8 | InterPro | 1763 | |||||
| UniProtKB:A0AB13ABN4 | InterPro | 2264 | |||||
| UniProtKB:A0AB32TYD5 | InterPro | 1840 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
svila-207
(1)
|
Ensembl | 750 nt | ||
| mRNA |
svila-201
(1)
|
Ensembl | 6,407 nt | ||
| mRNA |
svila-202
(1)
|
Ensembl | 511 nt | ||
| mRNA |
svila-203
(1)
|
Ensembl | 2,851 nt | ||
| mRNA |
svila-204
(1)
|
Ensembl | 553 nt | ||
| mRNA |
svila-205
(1)
|
Ensembl | 896 nt | ||
| mRNA |
svila-208
(1)
|
Ensembl | 8,812 nt | ||
| mRNA |
svila-209
(1)
|
Ensembl | 8,791 nt | ||
| ncRNA |
svila-005
(1)
|
Ensembl | 378 nt |
Interactions and Pathways
No data available
Plasmids
- Comparative Orthology
- Alliance